2024
DOI: 10.1002/oby.24124
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Maternal obesogenic diet during pregnancy and its impact on fetal hepatic function in baboons

Ashley S. Meakin,
Peter W. Nathanielsz,
Cun Li
et al.

Abstract: ObjectiveMaternal obesity (MO) increases the risk of later‐life liver disease in offspring, especially in males. This may be due to impaired cytochrome P450 (CYP) enzyme activity driven by an altered maternal‐fetal hormonal milieu. MO increases fetal cortisol concentrations that may increase CYP activity; however, glucocorticoid receptor (GR)‐mediated signaling can be modulated by alternative GR isoform expression. We hypothesized that MO induces sex‐specific changes in GR isoform expression and localization t… Show more

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