Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts

Casas, Maribel; Cordier, Sylvaine; Martínez, David; Barros, Henrique; Bonde, Jens Peter; Burdorf, Alex; Costet, Nathalie; Santos, Ana Cristina; Danilevičiūtė, Asta; Eggesbø, Merete; Fernández, Mariana F.; Févotte, Joëlle; García, Ana M.; Gražulevičienė, Regina; Hallner, Eva; Hanke, Wojciech; Kogevinas, Manolis; Kull, Inger; Larsen, Pernille Stemann; Melaki, Vasiliki; Monfort, Christine; Nordby, Karl-Christian; Andersen, Anne‐Marie Nybo; Patelarou, Evridiki; Polańska, Kinga; Richiardi, Lorenzo; Santa‐Marina, Loreto; Snijder, Claudia A.; Tardón, Adonina; Eijsden, Manon van; Vrijkotte, Tanja G. M.; Zugna, Daniela; Nieuwenhuijsen, Mark; Vrijheid, Martine

doi:10.5271/sjweh.3500

Cited by 58 publications

(48 citation statements)

References 36 publications

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“…Among these birth cohorts, 13 participated in a previous study regarding maternal occupations and birth outcomes (Casas et al 2015) and were invited to participate in this new study. All 13 birth cohorts agreed to participate, including a total of 221,837 mother–child pairs followed at birth in the cohorts from 11 different countries spanning all regions of Europe (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

Birks

Casas

García

et al. 2016

Environ Health Perspect

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Background:Women of reproductive age can be exposed to endocrine-disrupting chemicals (EDCs) at work, and exposure to EDCs in pregnancy may affect fetal growth.Objectives:We assessed whether maternal occupational exposure to EDCs during pregnancy as classified by application of a job exposure matrix was associated with birth weight, term low birth weight (LBW), length of gestation, and preterm delivery.Methods:Using individual participant data from 133,957 mother–child pairs in 13 European cohorts spanning births from 1994 through 2011, we linked maternal job titles with exposure to 10 EDC groups as assessed through a job exposure matrix. For each group, we combined the two levels of exposure categories (possible and probable) and compared birth outcomes with the unexposed group (exposure unlikely). We performed meta-analyses of cohort-specific estimates.Results:Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.Conclusion:Results from our large population-based birth cohort design indicate that employment during pregnancy in occupations classified as possibly or probably exposed to EDCs was associated with an increased risk of term LBW.Citation:Birks L, Casas M, Garcia AM, Alexander J, Barros H, Bergström A, Bonde JP, Burdorf A, Costet N, Danileviciute A, Eggesbø M, Fernández MF, González-Galarzo MC, Gražulevičienė R, Hanke W, Jaddoe V, Kogevinas M, Kull I, Lertxundi A, Melaki V, Andersen AM, Olea N, Polanska K, Rusconi F, Santa-Marina L, Santos AC, Vrijkotte T, Zugna D, Nieuwenhuijsen M, Cordier S, Vrijheid M. 2016. Occupational exposure to endocrine-disrupting chemicals and birth weight and length of gestation: a European meta-analysis. Environ Health Perspect 124:1785–1793; http://dx.doi.org/10.1289/EHP208

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Section: Methodsmentioning

confidence: 99%

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

Birks

Casas

García

et al. 2016

Environ Health Perspect

Self Cite

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“…In our study, the mean delay was significantly higher among those patients who had employed mother, and ordinal logistic regression also showed a higher odds of delayed diagnosis among employed mothers than unemployed ones, but without significance. Maternal occupation may affect infant health that was also considered in several studies (29,30). Time, for example maternal time for receiving healthcare, is an important factor to determine well-baby care receipt (31).…”

Section: Discussionmentioning

confidence: 99%

Delay in Diagnosis of Hemoglobulinopathies (Thalassemia, Sickle Cell Anemia): A Need for Management of Thalassemia Programs

et al. 2016

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Background: Hemoglobulinopathies (Thalassemia, Sickle cell anemia) are an important public health challenge worldwide with an estimated number of 330,000 affected newborns annually. Delay in diagnosis not only increases the morbidity and mortality rates, but also can lead to uncertainties about success of thalassemia prevention program (TPP). This study is the first to determine the delay in thalassemia diagnosis in Iranian population. Methods: This registry-based cross-sectional study was conducted on 1003 enrolled thalassemic patients in 2015 in Shiraz, Iran. Univariate and multivariate ordinal logistic regression models were used to assess the factors associated with delay in diagnosis. Results: Of 981 patients, 48.5% were female, 71.2% were thalassemia major, and 23.8% were death cases. The delay in diagnosis was observed among 64.9% of the patients with a mean of 13.4 months (95% CI: 10.9, 15.9). Multivariate ordinal logistic regression showed that girls (adjusted OR = 1.32), and dead patients (adjusted OR = 1.95) were more likely to have delayed diagnosis. There was an increasing trend of risk in delayed diagnosis associated with one-year per birth cohort. The ORs were 1.0, 1.52, 1.55, and 2.22, for birth cohort 1980 and earlier, 1981 -1990, 1991 -2000, and 2001 to the present, respectively (P for trend = 0.014). In addition, the odds of delayed diagnosis in thalassemia major patients were significantly 0.58 times lower than those with thalassemia intermedia. Conclusions: A high proportion of delayed diagnosis was found. These results could explain the poor outcomes for thalassemia patients. Educational programs for community and revising the TPP are required for early detection of the disease.

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“…мужний статус достоверно ассоциированы с рождением маловесных детей [7][8][9]. Данное обстоятельство, веро-ятнее всего, связано с тем, что наиболее образованные замужние женщины, имеющие регулярную трудовую дея-тельность, характеризуются наибольшим комплаенсом в отношении медицинских услуг, бо льшими интервалами между рождением детей, а также меньшим количеством материальных барьеров, что в свою очередь влияет на исход беременности.…”

Section: обсуждение основного результата исследованияunclassified

Risk Factors Associated With the Birth of Children With a Body Weight Less Than 2500 G: Results of a Retrospective Cohort Multicenter Study

Деев¹,

Kulikova²,

Кобякова³

et al. 2016

Pediatr. farmakol.

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Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts

Cited by 58 publications

References 36 publications

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

Delay in Diagnosis of Hemoglobulinopathies (Thalassemia, Sickle Cell Anemia): A Need for Management of Thalassemia Programs

Risk Factors Associated With the Birth of Children With a Body Weight Less Than 2500 G: Results of a Retrospective Cohort Multicenter Study

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