Maternal organic selenium supplementation during gestation improves the antioxidant capacity and reduces the inflammation level in the intestine of offspring through the NF-κB and ERK/Beclin-1 pathways

Abstract

Selenium (Se) is postulated to protect against inflammation in the gut by attenuating oxidative stress. This study was conducted to investigate the effects of maternal 2-hydroxy-4-methylselenobutanoic acid (HMSeBA), an organic...

Hydroxy-Selenomethionine, an Organic Selenium Source, Increases Selenoprotein Expression and Positively Modulates the Inflammatory Response of LPS-Stimulated Macrophages

“…Nelson et al [ 61 ] stated that Se supplementation was able to induce the polarization of bone marrow-derived macrophages from M1 macrophages towards M2 macrophages. Several studies have shown that OH-SeMet supplementation in non-stressed conditions is capable of decreasing the production of proinflammatory cytokines such as IL-1β or TNFα and increase the expression of anti-inflammatory cytokines such as IL-10 [ 24 , 37 , 62 , 63 , 64 ]. Nevertheless, contrary to NAC, when a challenge was induced, OH-SeMet supplementation helped the macrophages to control the cytokine production by decreasing both proinflammatory cytokines (TNFα and IL-1β) and maintaining the anti-inflammatory cytokine IL-10, as previously described in other tissues [ 27 , 37 , 64 ].…”

“…Several studies have shown that OH-SeMet supplementation in non-stressed conditions is capable of decreasing the production of proinflammatory cytokines such as IL-1β or TNFα and increase the expression of anti-inflammatory cytokines such as IL-10 [ 24 , 37 , 62 , 63 , 64 ]. Nevertheless, contrary to NAC, when a challenge was induced, OH-SeMet supplementation helped the macrophages to control the cytokine production by decreasing both proinflammatory cytokines (TNFα and IL-1β) and maintaining the anti-inflammatory cytokine IL-10, as previously described in other tissues [ 27 , 37 , 64 ]. It is important to remark that the control of IL-10 production is needed in stressed conditions since it is described that high IL-10 production leads to a suppression of the immune response and, therefore, a failure to control the infection [ 65 ].…”

2-Hydroxy-4-Methylselenobutanoic Acid Promotes Follicle Development by Antioxidant Pathway

“…The activities of glutathione peroxidase (GPX), glutathione reductase (GR), thioredoxin reductase (TXNRD), total antioxidative capability (T-AOC), total superoxide dismutase (T-SOD) and malondialdehyde (MDA) of gilts' serum, liver, ovary, and supernatant and GCs of in vitro experiment were quantified by the respective assay kits (Nanjing Jiancheng Institute, Jiangsu, China). Briefly, the activities of GPX, GR and SOD were assayed as described by Mou et al ( 19 ). MDA content was measured based on the thiobarbituric acid (TBA) method.…”

Advances in the Study of the Mechanism by Which Selenium and Selenoproteins Boost Immunity to Prevent Food Allergies

“…Recent studies have confirmed that Se can regulate the immune response of DCs in chickens, mice, and humans [ 49 , 65 , 66 , 67 ]. Potential mechanisms by which Se is involved in the regulation of immune cell function include reactive oxygen species production and species, calcium and redox signaling, extracellular signal-regulated kinase (ERK), hypoxia-inducible factor 1α (HIF-1α), and NF-κB pathways [ 67 , 68 , 69 , 70 , 71 , 72 ]. A recent study in mice demonstrated that low and high Se affect the secretion of cytokines and impair immune function in the spleen [ 73 ].…”