Maternal Outcomes Among Pregnant Women Diagnosed With COVID-19

Al-Zahrani, Ahlam; Alanazi, Latifah; Thabet, Hala; Alenezi, Faiz

doi:10.7759/cureus.33887

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…The course of the illness and neonatal outcome were investigated in a retrospective study carried out in the Hubei province, which included 16 pregnant women with COVID-19 infection and 45 pregnant women without COVID-19 who underwent C-section. In the events of fetal distress, meconium-stained amniotic fluid, premature delivery, and neonatal hypoxia, no notable differences were discovered and the neonates had no signs of infection [15] . Recent studies have reported the possibility of in utero COVID-19 transmission by measurement of fetal IgM blood level [16,17] .…”

Section: Discussionmentioning

confidence: 95%

Maternal and neonatal outcomes in pregnant women with COVID-19 in a tertiary care hospital

Priya¹,

Gangadhar²,

Patil³

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

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Background: The first case of the new Corona virus was identified in Wuhan, China in December 2019 and since then it spread around the world to other countries. The World health Organisation declared that the CoV-19 pandemic as a public health emergency of international concern (PHEIC) on 30 Jan 2020. In our hospital we managed Covid-19 positive patients as per guidelines. Here we are presenting the data of management and clinical outcomes of COVID-19 positive pregnant patients in our institution. Materials & Methodology:In this study we retrospectively reviewed the medical records of all COVID-19 positive pregnant women who were admitted to PESIMSR from January 2021 to August 2021, after obtaining permission from the institute. The infection status was determined via real-time polymerase chain reaction (RT-PCR) of nasopharyngeal swab specimen. In a pre-constructed data form the details regarding obstetric data, clinical status, symptoms, maternal and fetal outcomes were noted. Patients treated in an outpatient setting were not included. Results: 125 COVID-19 positive pregnant women were admitted in our hospital during study period. Mean maternal age was 23.9+_4.2 years. The mean gestational age calculated was 37.5±1.5 weeks. Cesare an section was performed in 33.6% of cases and 65.6% cases delivered vaginally. Most of the cases were asymptomatic. Patients with mild disease, without acute respiratory distress syndrome (ARDS), responded well to the supportive treatment. 10 babies required the admission in the new born intensive care unit and were discharged. All neonates tested negative for COVID-19, which showed no evidence of vertical transmission of COVID-19 in study group. Neither maternal nor neonatal deaths occurred. Conclusion: Our data showed that the course of Corona virus disease, COVID -19 in pregnancy is mild in the majority of cases and neonatal outcomes also appeared favourable.

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Section: Discussionmentioning

confidence: 95%

Maternal and neonatal outcomes in pregnant women with COVID-19 in a tertiary care hospital

Priya¹,

Gangadhar²,

Patil³

et al. 2023

Int. J. Clin. Obstet. Gynaecol.

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“…The observed adverse pregnancy outcomes were premature delivery (36.5%), fetal distress (20.7%), preeclampsia (2.4%), eclampsia (1.2%), and three maternal deaths. [ 22 ] In another analysis of 50 deliveries of COVID-infected mothers, there were a 94% cesarean rate and 35% preterm birth. [ 23 ] Our assessment revealed 9.61% miscarriage, 26.9% preterm delivery, 17.3% pre-eclampsia/eclampsia, 21.16% cesarean rate, and two maternal deaths.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of COVID-19 infection in pregnancy and puerperium in a suburban medical college in West Bengal, India

Mukherjee,

Burman,

Sarkar

et al. 2024

Journal of Family Medicine and Primary Care

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Background: The pandemic of SARS-CoV-2 was a novel situation, there was no conclusive knowledge, particularly concerning its effect on pregnant women and infants. Eminent obstetric organizations have introduced an array of guidelines to assist clinicians in countering this prior unknown outbreak. The primary objective of this study was to summarize the clinical characteristics, complications, and maternal and neonatal outcomes of COVID-19 during pregnancy and puerperium. Methods: This was a cross-sectional observational study conducted in the Outpatient/Emergency/Inpatient or COVID ward in the Department of Obstetrics and Gynaecology, of a tertiary hospital in Nadia district, West Bengal, India, from 1.7.2020 to 30.6.2021 including 104 pregnant or puerperal mothers with laboratory-confirmed, i.e., RT-PCR or Rapid Antigen Test positive reports after informed consent. The obstetric outcome, modes of delivery, and neonatal status including any complications or SNCU admission within six weeks postpartum were recorded. Results: The majority were in the ≥ 20–24 years age group, primigravida, residents of Nadia with no significant travel or contact history. 73.08% were affected in the third trimester and the comorbidities detected were chiefly anemia (15.38%), hypertensive or chronic liver diseases, and hypothyroidism. 45.19% of the mothers were asymptomatic while the other complaints were fever (18.27%), cough (11.55%), anosmia and/or ageusia (10.58%), sore throat (9.61%), respiratory distress, loose stools, and chest pain. The medical complications were predominantly low SpO2, convulsions, pneumonitis, and two maternal deaths. The obstetric complications were preterm birth (26.9%), pre-eclampsia/eclampsia (17.3%), antepartum (3.9%) and postpartum hemorrhage (4.4%), and sepsis (5.8%). Fourteen mothers had first-trimester termination, 63 had vaginal deliveries, and the rest had cesarean section. Out of 90 neonates, most were in the range of ≥ 2–2.5 kg birth weight and normal 1-min APGAR score. None tested positive for COVID-19 RTPCR and no detectable congenital anomaly or neonatal death was recorded.

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“…However, it is unknown how COVID-19 would affect fetal respiratory failure, intrauterine fetal death, premature birth, or abortion. 13…”

Section: Effects Of Covid-19 On Pregnancymentioning

confidence: 99%

The Medication Therapies and Existing COVID-19 Vaccines, the Nature of Manufacture, and the Degree of Immunity

Eslami Farsani,

Heidari,

Ababzadeh

et al. 2023

Int J Basic Sci Med

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The globe is currently dealing with one of the worst epidemics, SARS-CoV-2. The various drugs can treat the clinical symptoms of SARS-CoV-2, and combination therapies may be more effective than monotherapy. This study discussed various COVID-19 subtypes, pharmaceutical effectiveness, the advantages and disadvantages of medications, and mortality rates in various countries. The drugs were reviewed as well. The macrolides family can produce anti-inflammatory cytokines against COVID-19, but they may cause side effects such as bacterial resistance. Although anti-malarial drugs may inhibit the entrance of the virus into cells, they are not a common medicine in COVID-19 treatment. The simultaneous consumption of corticosteroids with other drugs can be beneficial for high-intensity patients. In addition, remdesivir may be effective in severe cases of the disease. However, the administration of several drugs can be more effective compared to a single drug. Although pharmacological combinations can be effective in treating SARS-CoV-2, vaccines are considered to be the most successful approach for reducing COVID-19. Pfizer/ BioNTech and Moderna vaccines are based on the mRNA of viruses and provide an efficiency of about 95%. Sputnik V was prepared by two replication-incompetent adenovirus vectors. The AstraZeneca–Oxford vaccine was prepared based on viral vectors, and its efficacy has a variable range of 62%–90%. The vaccines based on an inactivated virus provided innate immunity in the body. Soberana 2 is a recombinant vaccine. Generally, all vaccines may have positive effects on the prevention of COVID-19, but further clinical trials are necessary. These findings suggest each available vaccine is advised for protection against COVID-19.

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Maternal Outcomes Among Pregnant Women Diagnosed With COVID-19

Cited by 4 publications

References 36 publications

Maternal and neonatal outcomes in pregnant women with COVID-19 in a tertiary care hospital

Maternal and neonatal outcomes in pregnant women with COVID-19 in a tertiary care hospital

Evaluation of the effect of COVID-19 infection in pregnancy and puerperium in a suburban medical college in West Bengal, India

The Medication Therapies and Existing COVID-19 Vaccines, the Nature of Manufacture, and the Degree of Immunity

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