Maternal per- and poly-fluoroalkyl substances exposures associated with higher depressive symptom scores among immigrant women in the Chemicals in Our Bodies cohort in San Francisco

Aung, Max T.; Eick, Stephanie M.; Padula, Amy; Smith, Sabrina Crispo; Park, June-Soo; DeMicco, Erin; Woodruff, Tracey J.; Morello‐Frosch, Rachel

doi:10.1016/j.envint.2023.107758

Cited by 17 publications

(12 citation statements)

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“…Another study of 267 maternal-newborn dyads in Atlanta, GA reported that maternal PFAS exposures were associated with newborn metabolomic signatures for bioactive lipid metabolism including leukotrienes, cytochrome p450 pathway, and linoleic acid . Our findings align with existing evidence of the deleterious effects of PFAS exposure on pregnancy outcomes, as prenatal/perinatal PFAS exposure has been associated with multiple adverse birth outcomes including preterm birth, miscarriage, and maternal depression . Thus, our study underscores the importance of applying targeted metabolomics approaches to investigate the role of lipid metabolism as a potential intermediate mechanism of PFAS exposure on maternal and early child health outcomes.…”

Section: Discussionsupporting

confidence: 83%

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Suthar,

Manea,

Pak

et al. 2024

Environ. Sci. Technol.

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Prenatal per-and poly-fluoroalkyl substances (PFAS) exposure may influence gestational outcomes through bioactive lipids�metabolic and inflammation pathway indicators. We estimated associations between prenatal PFAS exposure and bioactive lipids, measuring 12 serum PFAS and 50 plasma bioactive lipids in 414 pregnant women (median 17.4 weeks' gestation) from three Environmental influences on Child Health Outcomes Program cohorts. Pairwise association estimates across cohorts were obtained through linear mixed models and meta-analysis, adjusting the former for false discovery rates. Associations between the PFAS mixture and bioactive lipids were estimated using quantile g-computation. Pairwise analyses revealed bioactive lipid levels associated with PFDeA, PFNA, PFOA, and PFUdA (p < 0.05) across three enzymatic pathways (cyclooxygenase, cytochrome p450, lipoxygenase) in at least one combined cohort analysis, and PFOA and PFUdA (q < 0.2) in one linear mixed model. The strongest signature revealed doubling in PFOA corresponding with PGD2 (cyclooxygenase pathway; +24.3%, 95% CI: 7.3−43.9%) in the combined cohort. Mixture analysis revealed nine positive associations across all pathways with the PFAS mixture, the strongest signature indicating a quartile increase in the PFAS mixture associated with PGD2 (+34%, 95% CI: 8−66%), primarily driven by PFOS. Bioactive lipids emerged as prenatal PFAS exposure biomarkers, deepening insights into PFAS' influence on pregnancy outcomes.

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Section: Discussionsupporting

confidence: 83%

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Suthar,

Manea,

Pak

et al. 2024

Environ. Sci. Technol.

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“…For example, a previous study identified that Black women (median age 49) had higher risk of developing hypertension compared to White women (Ding et al 2023). Our team also identified increased depressive symptoms in association with higher PFAS exposure among immigrant pregnant women compared to U.S. born pregnant women (median age 34) in the Chemicals in Our Bodies cohort (Aung et al 2023). Widespread evidence of environmental and human exposure, coupled with associated health effects, warrants detailed investigation into intermediate mechanisms of PFAS toxicity to inform risk assessment and identify potential intervention targets.…”

Section: Introductionmentioning

confidence: 74%

“…Additionally, biomonitoring of PFAS in NHANES and the Environmental influences on Child Health Outcomes Program indicates moderate correlation between individual compounds, highlighting the need to consider PFAS as a mixture to evaluate cumulative health effects and ameliorate residual confounding (Calafat et al, 2007, Padula et al 2023.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional associations between prenatal maternal per- and poly-fluoroalkyl substances and bioactive lipids in three Environmental influences on Child Health Outcomes (ECHO) cohorts

Suthar,

Manea,

Pak

et al. 2023

Preprint

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BackgroundPer- and poly-fluoroalkyl substances (PFAS) exposure can occur through ingestion of contaminated food and water, and inhalation of indoor air contaminated with these chemicals from consumer and industrial products. Prenatal PFAS exposures may confer risk for pregnancy-related outcomes such as hypertensive and metabolic disorders, preterm birth, and impaired fetal development through intermediate metabolic and inflammation pathways.ObjectiveEstimate associations between maternal pregnancy PFAS exposure (individually and as a mixture) and bioactive lipids.MethodsOur study included pregnant women in the Environmental influences on Child Health Outcomes Program: Chemicals in our Bodies cohort (CiOB, n=73), Illinois Kids Developmental Study (IKIDS, n=287), and the ECHO-PROTECT cohort (n=54). We measured twelve PFAS in serum and 50 plasma bioactive lipids (parent fatty acids and eicosanoids derived from cytochrome p450, lipoxygenase, and cyclooxygenase) during pregnancy (median 17 gestational weeks). Pairwise associations across cohorts were estimated using linear mixed models and meta-analysis. Associations between the PFAS mixture and individual bioactive lipids were estimated using quantile g-computation.ResultsPFDeA, PFOA, and PFUdA were associated (p<0.05) with changes in bioactive lipid levels in all three enzymatic pathways (cyclooxygenase [n=6 signatures]; cytochrome p450 [n=5 signatures]; lipoxygenase [n=7 signatures]) in at least one combined cohort analysis. The strongest signature indicated that a doubling in PFOA corresponded with a 24.3% increase (95% CI [7.3%, 43.9%]) in PGD2 (cyclooxygenase pathway) in the combined cohort. In the mixtures analysis, we observed nine positive signals across all pathways associated with the PFAS mixture. The strongest signature indicated that a quartile increase in the PFAS mixture was associated with a 34% increase in PGD2 (95% CI [8%, 66%]), with PFOS contributing most to the increase.ConclusionsBioactive lipids were revealed as biomarkers of PFAS exposure and could provide mechanistic insights into PFAS’ influence on pregnancy outcomes, informing more precise risk estimation and prevention strategies.

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“…21 Nevertheless, there is a scarcity of research investigating the relationship between PFOS and depression, with existing findings presenting inconsistencies. 22,23 Conclusive evidence is required to ascertain whether PFOS can indeed cause depression.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that human exposure to PFOS and PFOS-related compounds is associated with various toxic effects, including immunotoxicity, hepatotoxicity, endocrine toxicity, cardiovascular toxicity, and neurotoxicity. − Numerous studies have illustrated the depressive effect of POPs, such as polychlorinated biphenyls, bisphenol A, and nonylphenol . Nevertheless, there is a scarcity of research investigating the relationship between PFOS and depression, with existing findings presenting inconsistencies. , Conclusive evidence is required to ascertain whether PFOS can indeed cause depression.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal Proteomics Reveals the Role of Glutamatergic Synapse Activation in the Depression Induced by Perfluorooctane Sulfonate

Yang

Xiao

et al. 2023

J. Agric. Food Chem.

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Perfluorooctane sulfonate (PFOS), a new type of persistent organic pollutant in the environment of water, has drawn significant attention in recent years due to its widespread prevalence and high toxicity. Neurotoxicity is regarded as one of the major toxic effects of PFOS, while research studies on PFOS-induced depression and the underlying mechanisms remain scarce. In this study, behavioral tests revealed the depressive-like behaviors in PFOS-exposed male mice. Neuron damages including pyknosis and staining deepening were identified through hematoxylin and eosin staining. Then, we noticed the elevation of glutamate and proline levels as well as the decline of glutamine and tryptophan levels. Proteomics analysis identified 105 differentially expressed proteins that change in a dose-dependent manner and revealed that PFOS exposure activated the glutamatergic synapse signaling pathway, which were further confirmed by Western blot, and the data were consistent with the findings of the proteomics analysis. Additionally, the downstream signaling cyclic AMP-responsive element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) and synaptic plasticity-related postsynaptic density protein 95, synaptophysin, were downregulated. Our results highlight that PFOS exposure may inhibit the synaptic plasticity of the hippocampus via glutamatergic synapse and the CREB/BDNF signaling pathway to cause depressive-like behaviors in male mice.

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Maternal per- and poly-fluoroalkyl substances exposures associated with higher depressive symptom scores among immigrant women in the Chemicals in Our Bodies cohort in San Francisco

Cited by 17 publications

References 50 publications

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts

Cross-sectional associations between prenatal maternal per- and poly-fluoroalkyl substances and bioactive lipids in three Environmental influences on Child Health Outcomes (ECHO) cohorts

Hippocampal Proteomics Reveals the Role of Glutamatergic Synapse Activation in the Depression Induced by Perfluorooctane Sulfonate

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