Maternal Phenylalanine Deprivation in the Rat Enzymatic and Cellular Liver Changes in the Offspring

The Effect of Limited, Moderate and Lengthy Daily Separation from the Mother during the Early Postnatal Period of the Rat on Concurrent and Subsequent Growth, and on Concurrent Oxygen Consumption at, as well as below, Thermal Neutrality

“…Some of its protein is used in the same ways adults use theirs, to carry on the processes necessary to meet the demands of maintaining homeostasis. In ad dition, it is experiencing a rapid increase in cell number [21], as well as un dergoing differentiation and activation of various hormones and enzymes [1,5,9]. The first of these in particular requires large amounts of protein.…”

“…The evidence that a cessation, rather than a slowdown, was involved lies in the fact that the subsequent effect on growth was as great in T16 as it was in T20. There is no basis for even speculating on what process or processes may have been involved, but one should not ignore the possible involvement of the thyroid [1,4,21].…”

Historical perspective: tyrosine and maternal phenylketonuria, welcome news

“…Fisch et al (11) reported a higher than normal incidence of intrauterine growth abnormalities in PKU in early as well as late stages of gestation, supporting the view that the problem with PKU is gestational (7). Mental retardation in PKU can best be explained by a gestational deficiency of tyrosine, tyrosine being critical to the growth and function of the brain.…”