Maternal plasma Elabela levels in intrauterine growth restriction

Baylan, Filiz Alkan; Karaküçük, Selim

doi:10.17826/cumj.976828

Cited by 1 publication

(1 citation statement)

References 22 publications

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“…For RIA tests, gamma radiation was quantified using the Wallac Wizard 1470 Gamma Counter (Perkin Elmer, Waltham, MA, USA). ELISA measurements were carried out on a Synergy 2 microplate reader (Biotek, Winooski, VT, USA) [20,21].…”

Section: Metabolic and Hormonal Profile In Blood Serummentioning

confidence: 99%

Changes in MOTS-c Level in the Blood of Pregnant Women with Metabolic Disorders

Wojciechowska

Pruszyńska‐Oszmałek

Kołodziejski

et al. 2021

Biology

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MOTS-c peptide is a member of the group of mitochondria-derived peptides (MDP). It is a product of the open reading frame in the 12S RNA gene. Due to its features and functions in the body, this peptide is classified as a hormone. The first publications indicated that this hormone improves insulin sensitivity and lowers body weight in obese animals. This suggests that it may be an important peptide in maintaining the body's energy homeostasis. The aim of our work was to investigate the potential role of MOTS-c peptide during pregnancy, which is a condition prone to metabolic disorders. The research covered healthy, obese women and women with thyroid disorders. The obtained results indicated an increase in the concentration of MOTS-c in the blood of mothers and newborns in the obese group as compared to the healthy control group and a corresponding decrease in the concentration of this peptide in mothers and newborns in the group with hypothyroidism compared to the obese group. Moreover, we also observed a strong positive correlation between the concentration of MOTS-c in maternal blood and in umbilical cord blood. In summary, the MOTS-c peptide shows changes in blood concentration in various physiological states and may, in the future, become an important tool in the fight against metabolic diseases such as obesity or type 2 diabetes.

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Section: Metabolic and Hormonal Profile In Blood Serummentioning

confidence: 99%