Maternal Plasma Hypoxanthine Levels in Nonpreeclamptic Twin Pregnancies

Abstract

We have observed that the elevated plasma adenosine levels are associated with hyperuricemia in nonpreeclamptic twin pregnancies. In animal models, extracellular adenosine is taken up by cells to form adenine nucleotides or is degraded to other purine metabolites such as hypoxanthine, which is further metabolized to xanthine and uric acid. In this study, we measured plasma hypoxanthine levels to evaluate the role of adenosine in hyperuricemia among women with twin pregnancies. Maternal blood samples were taken in 13 twin and 20 singleton pregnancies at 35-36 weeks' gestation. The average maternal plasma hypoxanthine level in twin pregnancies was significantly higher than that in singleton pregnancies. In addition, the plasma hypoxanthine levels have positive correlations both with plasma adenosine and serum uric acid levels. Our results support that an increased adenosine is the main factor contributing to hyperuricemia in twin pregnancies.hypoxanthine; adenosine; uric acid; twin pregnancy

IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites

“…In fact, high levels of IL-10 were observed in pregnant mice in this study. On the other hand, maternal metabolism, such as glucose, lipid [ 54 , 55 ], and purine metabolism [ 56 ], changes significantly during pregnancy considering that the alteration in host nutrient conditions may be associated with an enhancement of parasite-growth during pregnancy.…”

Effect of changes in renal circulation on serum uric acid levels in women with twin pregnancy

“…In an earlier study by Fischer et al [5], a 24-h urine collection was performed, and the higher maternal serum uric acid levels were demonstrated to result from increased uric acid production, as reflected in the increased daily uric acid excretion in twin pregnancies. In addition, our previous reports suggested that increased plasma adenosine is the main factor contributing to hyperuricemia in women with twin pregnancies [4,15]. Adenosine is a precursor for synthesis of adenosine triphosphate, and is a potent vasodilator and a metabolic regulator in the cardiovascular system [16].…”

Different Pharmacological Properties of GLUT9a and GLUT9b: Potential Implications in Preeclampsia

“…In pregnancy, serum uric acid concentrations decrease during the first trimester by at least 25%, and return to normal levels between the second and third trimester of pregnancy [17]. It has been shown that maternal serum uric acid concentrations rise in multiple pregnancies [18][19][20][21], suggesting that the presence of fetus and/or placenta contributes to the increased production of uric acid. Preeclampsia is a pregnancy-specific disease, characterized by hypertension and proteinuria, which contributes substantially to the incidence of iatrogenic preterm deliveries with its sequelae.…”