Maternal plasma lipopolysaccharide binding protein (LBP) concentrations in pregnancy complicated by preterm premature rupture of membranes

Torbé, Andrzej; Sokołowska, Małgorzata; Kwiatkowski, Sebastian; Rzepka, Rafał; Torbé, Bogdan; Czajka, Ryszard

doi:10.1016/j.ejogrb.2011.01.024

Cited by 6 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most prevalent cause of spontaneous preterm labor is local or generalized infection [ 5 – 7 ]. Infection leads to activation of the immune system via toll-like receptors and cytokine overproduction.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Potential of Evaluation of SDF-1αand sRAGE Levels in Threatened Premature Labor

Rzepka

Dołęgowska

Rajewska

et al. 2016

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 and 36 weeks of gestation, with premature labor, who finally had preterm birth. Group B contained 66 women in labor between 37 and 41 weeks of gestation. Women in group A had lower SDF-1α and sRAGE levels than those in group B. Moreover, in group A, SDF-1α and sRAGE levels were correlated with the latency period from the occurrence of premature labor symptoms until delivery. Sensitivity and specificity of studied parameters for prediction of preterm birth were 95% and 40% for SDF-1α and 51.3% and 93.5% for sRAGE, respectively. The prognostic value of plasma SDF-1α and sRAGE levels was comparable with that of cervical length ultrasound measurement and serum C-reactive protein levels. We conclude that SDF-1α and sRAGE appear to play a major role in the diagnosis of preterm birth and its evaluation could be convenient and useful for predicting preterm birth.

show abstract

Section: Introductionmentioning

confidence: 99%

Diagnostic Potential of Evaluation of SDF-1αand sRAGE Levels in Threatened Premature Labor

Rzepka

Dołęgowska

Rajewska

et al. 2016

BioMed Research International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Most authors associate PROM in premature pregnancy with an infection of the lower pole of conceptus, and subsequent intrauterine infection [27][28][29][30][31]. Recent research has proved an important role of cytokines in the onset and development of this kind of pregnancy complication [32][33][34]. However, not always does vaginal and/or cervical microbial colonization result in pPROM…”

Section: Discussionmentioning

confidence: 99%

Novel inflammatory markers of labor following premature preterm rupture of membranes

Rzepka¹,

Dołęgowska²,

Marczuk³

et al. 2019

Clin. Exp. Obstet. Gynecol.

View full text Add to dashboard Cite

The aim of the study was comparison of levels of resistin (RE), soluble receptor for advanced glycation end products (sRAGE), soluble receptor activator for nuclear factor-κB ligand (sRANKL), osteoprotegerin (OPG), glucose (GL), total protein (TP), and albumin (AL) between women with preterm and term rupture of fetal membranes and evaluation of prognostic values of all above in diagnostic of premature labor. Ninety-eight women in singleton pregnancy presenting with premature rupture of fetal membranes were included and divided into two groups: A -49 women after 37 weeks and B -49 women before 36 weeks of gestation. Plasma levels of sRAGE, OPG, TP, and AL were significantly lower in group B, and RE and GL plasma levels were higher in this group. The high prognostic values for sRAGE and sRANKL in the prognosis of spontaneous delivery after preterm rupture of membranes (pPROM) were found. The authors concluded that sRAGE and sRANKL serum levels could be a useful prognostic factors after pPROM. Resistin can play role in pathogenesis of rupture of membranes in premature pregnancy.

show abstract

“…According to this hypothesis, LBP as the component of the innate immune system could be increased in the early stage of intra-amniotic inflammation and FIRS. The studies of LBP in PPROM have been limited to measurement of LBP concentrations in amniotic fluid and maternal blood [11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide-Binding Protein as Marker of Fetal Inflammatory Response Syndrome after Preterm Premature Rupture of Membranes

Pavcnik-Arnol

Lučovnik²,

Kornhauser‐Cerar³

et al. 2013

Neonatology

View full text Add to dashboard Cite

Background: Intra-amniotic inflammation with preterm premature rupture of membranes (PPROM) is a risk factor for fetal inflammatory response syndrome (FIRS) and adverse neonatal outcome. Objectives: To evaluate the diagnostic accuracy of lipopolysaccharide-binding protein (LBP) for detecting FIRS in preterm neonates born after PPROM. Methods: This was a prospective study in the level III neonatal intensive care unit (42 neonates; 23 + 6 to 31 + 6 weeks' gestation) of mothers with PPROM. Umbilical cord blood concentrations of LBP, C-reactive protein (CRP), interleukin (IL)-6 and white blood cell count with differential were measured at delivery and 24 h after birth. Neonates were classified into FIRS (n = 22) and no FIRS (n = 20) groups according to clinical criteria and IL-6 level (≥17.5 pg/ml). Histological examination of the placenta and umbilical cord was performed. Neurological examination at 12 months' corrected age was performed. Results: Umbilical cord blood concentration of LBP was significantly higher in the FIRS group than in the no FIRS group at delivery (median 21.6 mg/l vs. median 2.3 mg/l; p < 0.0001) and 24 h after birth (median 17.2 mg/l vs. median 20.0 mg/l; p < 0.001). The area under the ROC curve for FIRS at delivery was 0.98 (95% CI 0.88-1.0) for LBP, 0.92 (95% CI 0.80-0.99) for CRP and 0.82 (95% CI 0.64-0.94) for immature to total neutrophil ratio. Similar results were obtained if FIRS was defined by funisitis. Umbilical cord blood concentration of LBP at delivery was significantly higher in neonates with abnormal neurological exam at 12 months than in those with normal exam (median 19.5 mg/l vs. median 3.75 mg/l; p < 0.015). Conclusions: In preterm neonates born to asymptomatic women with PPROM, LBP in cord blood at delivery is an excellent diagnostic biomarker of FIRS/funisitis with prognostic potential.

show abstract

Maternal plasma lipopolysaccharide binding protein (LBP) concentrations in pregnancy complicated by preterm premature rupture of membranes

Cited by 6 publications

References 18 publications

Diagnostic Potential of Evaluation of SDF-1αand sRAGE Levels in Threatened Premature Labor

Diagnostic Potential of Evaluation of SDF-1αand sRAGE Levels in Threatened Premature Labor

Novel inflammatory markers of labor following premature preterm rupture of membranes

Lipopolysaccharide-Binding Protein as Marker of Fetal Inflammatory Response Syndrome after Preterm Premature Rupture of Membranes

Contact Info

Product

Resources

About