Maternal polychlorinated biphenyl 126 (PCB 126) exposure modulates offspring gut microbiota irrespective of diet and exercise

Agarwal, Manisha; Hoffman, Jessie B.; Tenlep, Sara Y. Ngo; Santarossa, Sarah; Sitarik, Alexandra R.; Cassidy‐Bushrow, Andrea E.; Petriello, Michael C.

doi:10.1016/j.reprotox.2023.108384

Cited by 4 publications

(2 citation statements)

References 70 publications

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“…One study found that when mice were exposed to PCBs, the abundance of Proteobacteria was decreased, but PA attenuated this decrease [118]. A second study presented more mitigated results when observing the effect of PA on the gut microbiota of mice following maternal exposure to PCBs [124].…”

Section: The Link Between Pops Pa and Gut Microbiotamentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2024

IJMS

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Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs’ adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis, and gut microbiota dysbiosis, that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery, where weight loss promotes POPs’ blood release.

show abstract

Section: The Link Between Pops Pa and Gut Microbiotamentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…One study found that when mice were exposed to PCBs, the abundance of proteobacteria was decreased but PA attenuated this decrease [115]. A second study presented more mitigated results when observing the effect of PA on gut microbiota of mice following maternal exposure to PCBs [121].…”

Section: The Link Between Pops Pa and Gut Microbiotamentioning

confidence: 99%

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Serrano,

Le Garf,

Martin

et al. 2023

Preprint

View full text Add to dashboard Cite

Obesity affects nearly 660 million adults worldwide and is known for its many comorbidities. Although the phenomenon of obesity is not fully understood, science regularly reveals new determinants of this pathology. Among them, the persistent organic pollutants (POPs) have been recently highlighted. Mainly lipophilic, POPs are normally stored in adipose tissue and can lead to adverse metabolic effects when released into the bloodstream. The main objective of this narrative review is to discuss the different pathways by which physical activity may counteract POPs adverse effects. The research that we carried out seems to indicate that physical activity could positively influence several pathways negatively influenced by POPs, such as insulin resistance, inflammation, lipid accumulation, adipogenesis and gut microbiota dysbiosis that are associated with the development of obesity. This review also indicates how, through the controlled mobilization of POPs, physical activity could be a valuable approach to reduce the concentration of POPs in the bloodstream. These findings suggest that physical activity should be used to counteract the adverse effects of POPs. However, future studies should accurately assess its impact in specific situations such as bariatric surgery where weight loss promotes POPs blood release.

show abstract

Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system

Peixoto-Rodrigues,

Monteiro-Neto,

Teglas

et al. 2025

Journal of Hazardous Materials

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Maternal polychlorinated biphenyl 126 (PCB 126) exposure modulates offspring gut microbiota irrespective of diet and exercise

Cited by 4 publications

References 70 publications

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review

Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system

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