Maternal polycystic ovary syndrome and attention deficit hyperactivity disorder in offspring at 3 years of age: Odense Child Cohort

Dalgaard, Cilia M.; Andersen, Marianne; Jensen, Richard Christian; Larsen, Pia Veldt; Boye, Henriette; Bilenberg, Niels; Glintborg, Dorte

doi:10.1111/aogs.14259

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…Two Swedish registry-based studies reported a stronger association between maternal PCOS exposure and ADHD in female offspring than in male offspring ( 10 , 13 ), whereas the Finnish population study reported a similar risk estimate for boys and girls ( 14 ). In contrast, the Odense child cohort study involving 1776 mothers reported a positive association (adjusted OR = 2.20, 95% CI: 1.20–4.02) between maternal PCOS and ADHD in male offspring but not in female offspring (adjusted OR = 0.43, 95% CI: 0.13–1.42) ( 15 ). Our findings are consistent with those from the Odense cohort study, showing a tendency for a stronger association between maternal PCOS and offspring ADHD in boys than in girls.…”

Section: Discussionmentioning

confidence: 99%

“…For example, two Swedish studies reported a stronger association between maternal PCOS and offspring ADHD in girls than in boys ( 10 , 13 ). In contrast, the Odense Child Cohort in Denmark reported a significant correlation between maternal PCOS and ADHD symptoms in boys but not in girls ( 15 ). Therefore, further studies are required to clarify sex differences in the association between maternal PCOS and offspring ADHD.…”

Section: Introductionmentioning

confidence: 91%

“…Although ADHD predominantly occurs in males ( 1 ), it remains unclear whether boys are more susceptible to maternal PCOS exposure than girls ( 13 – 15 ). For example, two Swedish studies reported a stronger association between maternal PCOS and offspring ADHD in girls than in boys ( 10 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

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Association between maternal polycystic ovary syndrome and attention-deficit/hyperactivity disorder in offspring aged 3–6 years: A Chinese population-based study

Zhang

Guo

et al. 2023

Front. Public Health

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BackgroundMaternal polycystic ovary syndrome (PCOS) may increase the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring; however, their association remains unexplored in Asian populations. Hence, this study aimed to investigate the association between maternal PCOS and ADHD in offspring aged 3–6 years and whether it differed by offspring sex.MethodsThis was a district-wide population-based study of 87,081 preschoolers from 234 kindergartens in Longhua District, Shenzhen, China. The parents were invited to complete a self-administrated questionnaire covering information on socio-demographics, maternal disease history, and child behavior. ADHD symptoms were measured with the parent-rating 26-item Swanson, Nolan, and Pelham Rating Scale (SNAP-IV). Logistic regression was performed to examine the associations between maternal PCOS and ADHD symptoms in offspring.ResultsThe response rate was 80% and 63,390 mother-child pairs were included. Of the mothers, 1,667 (2.6%) reported PCOS diagnoses. The mean age of children at ADHD assessment was 4.86 ± 0.84[SD] years, and 53.6% were boys. Children with maternal PCOS had a higher risk of developing ADHD symptoms than other children (12.0 vs. 9.4%, adjusted odds ratio [OR] = 1.32, 95% CI: 1.13–1.54). The risk estimate was significant in boys (adjusted OR = 1.38, 95% CI: 1.14–1.66) but not in girls (adjusted OR = 1.23, 95% CI: 0.94–1.57, P for interaction = 0.391). Treatment of PCOS tended to be associated with a lower risk of ADHD symptoms than untreated PCOS albeit risk confidence intervals were overlapped (treated: adjusted OR = 1.28, 95% CI: 1.06–1.54 vs. untreated: adjusted OR = 1.14, 95% CI: 1.08–1.83).ConclusionMaternal PCOS increases the risk of developing ADHD in offspring, especially boys. Further studies are warranted to confirm our findings, and early neurodevelopmental screening may be needed in children born to mothers with PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

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Association between maternal polycystic ovary syndrome and attention-deficit/hyperactivity disorder in offspring aged 3–6 years: A Chinese population-based study

Zhang

Guo

et al. 2023

Front. Public Health

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“…There is emerging evidence linking PCOS and psychiatric disorders in PCOS patients and their offspring. Women with PCOS have greater odds of depression, anxiety disorder, 7–23 bipolar affective disorder, schizophrenia, social phobia, obsessive‐compulsive disorder, eating disorders, sleep disturbance, and attention deficit hyperactivity disorder (ADHD), 4,24–35 as well as an increased prevalence of ADHD, autism spectrum disorder (ASD), chronic tic disorder, and other behavior disorders in their children 26,36–43 . Furthermore, women with PCOS have a higher risk of both persistence of existing psychiatric disorders and the emergence of new psychiatric disorders during follow up 17,44,45 .…”

Section: Introductionmentioning

confidence: 99%

“…greater odds of depression, anxiety disorder, [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] bipolar affective disorder, schizophrenia, social phobia, obsessive-compulsive disorder, eating disorders, sleep disturbance, and attention deficit hyperactivity disorder (ADHD), 4,[24][25][26][27][28][29][30][31][32][33][34][35] as well as an increased prevalence of ADHD, autism spectrum disorder (ASD), chronic tic disorder, and other behavior disorders in their children. 26,[36][37][38][39][40][41][42][43] Furthermore, women with PCOS have a higher risk of both persistence of existing psychiatric disorders and the emergence of new psychiatric disorders during follow up. 17,44,45 Concurrently, psychological disorders may make PCOS treatment more challenging.…”

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confidence: 99%

New insights into the interaction between polycystic ovary syndrome and psychiatric disorders: A narrative review

Geng

Huang

et al. 2023

Intl J Gynecology & Obste

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Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease characterized by hyperandrogenism, ovulatory dysfunction, and ovarian polycystic changes, which combines with reproductive problems, metabolic disorders, and psychological disorders to exhibit a far‐reaching impact on the physical and mental health of women. We reviewed previous research and discovered that psychiatric disorders are more common in PCOS patients and their children, potentially exacerbating the condition and creating a vicious loop. To understand the reasons, relevant articles were collected following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines from PubMed, Web of Science, and Cochrane Library, through December 2022. Evidence suggested that PCOS‐related clinical manifestations, hyperandrogenism, insulin resistance, obesity, gut dysbiosis, and other variables may increase the risk of psychiatric disorders in patients. In turn, psychiatric disorders may aggravate the pathologic process of PCOS and increase the difficulty of the treatment. We systematically reported the mechanisms underlying the psychiatric disorders‐PCOS interactions, intending to provide potential ways to break the vicious cycle and lay the groundwork for future research. However, research on PCOS and psychiatric disorders were still in initial stages, which limited the scope of this review. More studies are needed to further verify our findings.

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Effects of Maternal Internal Environment on Early Life Growth and Development

Zhou

Ren

Ding

et al. 2023

In Utero Pediatrics

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Maternal polycystic ovary syndrome and attention deficit hyperactivity disorder in offspring at 3 years of age: Odense Child Cohort

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 8 publications

References 41 publications

Association between maternal polycystic ovary syndrome and attention-deficit/hyperactivity disorder in offspring aged 3–6 years: A Chinese population-based study

Association between maternal polycystic ovary syndrome and attention-deficit/hyperactivity disorder in offspring aged 3–6 years: A Chinese population-based study

New insights into the interaction between polycystic ovary syndrome and psychiatric disorders: A narrative review

Effects of Maternal Internal Environment on Early Life Growth and Development

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