Maternal postpartum depressive symptoms predict delay in non-verbal communication in 14-month-old infants

Kawai, Emiko; Takagai, Shu; Takei, Nori; Itoh, Hiroaki; Kanayama, Naohiro; Tsuchiya, Kenji J.; Team, Hbc Study

doi:10.1016/j.infbeh.2016.11.006

Cited by 27 publications

(16 citation statements)

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“…First, maternal depression during the prenatal and toddler periods was related to child communication skills at age 5, but postpartum depression was not. While some previous studies have found that postpartum depression predicts lower child communication and language skills (Kawai et al, 2017; Valla, Wentzel‐Larsen, Smith, Birkeland, & Slinning, 2016), others have not (Cornish et al, 2005; Paulson, Keefe, & Leiferman, 2009; Piteo, Yelland, & Makrides, 2012). Prior research has almost exclusively examined the effects of postnatal depression on child communication and language during infancy or toddlerhood.…”

Section: Discussionmentioning

confidence: 97%

The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5

et al. 2020

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Background Maternal depression and anxiety have been associated with deleterious child outcomes. It is, however, unclear how the chronicity and timing of maternal mental health problems predict child development outcomes. The aim of the current study was to assess the effect of both chronicity and timing of maternal anxiety and depression in pregnancy, infancy, and the toddler period on children's internalizing and externalizing symptoms, as well as social and communication skills at age 5. Method Participants were 1,992 mother–child pairs drawn from a large prospective pregnancy cohort. Mothers reported on anxiety and depression symptoms with clinical screening tools at six time points between <25 weeks gestation and 3 years postpartum. Child outcomes were assessed at age 5. Results Effect sizes were small for brief incidents of depression/anxiety and increased for intermittent and chronic problems (i.e., three or more timepoints) compared with mothers who had never experienced clinical‐level anxiety or depression. Maternal anxiety/depression during pregnancy, infancy, and toddlerhood predicted all child outcomes, even after controlling for depression/anxiety during the other timepoints. However, maternal anxiety and depression during toddlerhood had a stronger association with child internalizing/externalizing symptoms and communication skills than either prenatal or postpartum depression/anxiety. Conclusions Increasing number of exposures to clinical‐level anxiety and depression is related to poorer child outcomes. Neither prenatal nor postpartum periods emerged as “sensitive” periods. Rather, maternal depression and anxiety during toddlerhood was more strongly associated with child outcomes at age 5. Results highlight the need for continued support for maternal mental health across early childhood.

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Section: Discussionmentioning

confidence: 97%

The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5

et al. 2020

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“…PPD has been associated with impaired mother-infant bonding [48]. Children of women with PPD exhibit poor cognitive [49,50], neuropsychological [51,52], social and emotional skills [53,54] across childhood through adolescence. PPD can be long lasting [55]: women with persistent depressive symptoms at eight months postpartum showed elevated depressive symptoms when their child was eleven years old [56].…”

Section: Impact Of Untreated Ppdmentioning

confidence: 99%

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

et al. 2019

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Postpartum depression is one of the most common complications of childbirth. Untreated postpartum depression can have substantial adverse effects on the well-being of the mother and child, negatively impacting child cognitive, behavioral, and emotional development with lasting consequences. There are a number of therapeutic interventions for postpartum depression including pharmacotherapy, psychotherapy, neuromodulation and hormonal therapy among others, most of which have been adapted from the treatment of major depressive disorder outside of the peripartum period. Current evidence of antidepressant treatment for postpartum depression is limited by the small number of randomized clinical trials, underpowered samples and lack of longterm follow-up. The peripartum period is characterized by rapid and significant physiological change in plasma levels of endocrine hormones, peptides and neuroactive steroids. Evidence supporting the role of neuroactive steroids and GABA in the pathophysiology of postpartum depression led to the investigation of synthetic neuroactive steroids and their analogs as potential treatment for postpartum depression. Brexanolone, a soluble, proprietary, intravenous preparation of synthetic allopregnanolone has been developed. A recent series of open-label and placebocontrolled randomized clinical trials of brexanolone in postpartum depression demonstrated rapid reduction of depressive symptoms, and have led to the submission for regulatory approval to the US Food and Drug Administration (decision due in March 2019). SAGE-217, an allopregnanolone analog, with oral bioavailability, was recently tested in a randomized, double-blind, placebocontrolled phase 3 study in severe postpartum depression, with reportedly positive results. Finally,

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“…While previous studies have used other measurements such as the Bayley Scales of Intellectual Development, the advantage of the MSEL is that it obtains non-verbal and verbal skills separately (Akshoomoff, 2006). Expressive language development is guided by the development of non-verbal communication skills, which occurs earlier in life (Iverson & Goldin-Meadow, 2005;Kawai et al, 2017). Additionally, expressive language skills might reflect interaction with other domains, such as motor skills and receptive language (Mullen, 1995).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #1 of "Association of late-onset postpartum depression of mothers with expressive language development during infancy and early childhood: the HBC study (v0.1)"

2019

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Background.While it has been implied that an infant's exposure to maternal postpartum depression (PPD) may be associated with delayed development of expressive language, it remains unclear whether such a delay persists into childhood and whether the onset of PPD onset-early (within 4 weeks after childbirth) vs. late (between 5 and 12 weeks postpartum)-is relevant in this context. Objective. To examine whether children of mothers with early-or late-onset PPD have reduced expressive language scores during infancy and early childhood (up to 40 months of age). Methods. This longitudinal, observational study was conducted as a part of the Hamamatsu Birth Cohort for Mothers and Children (HBC Study), a population-representative sample in Japan. A total of 969 neonates and their mothers were included in the analysis. Exposures. Early-and late-onset PPD was measured using the Edinburgh Postnatal Depression Scale. Main Outcomes and Measures. Expressive language development was measured using the Mullen Scales of Early Learning. Six points over time were monitored (10, 14, 18, 24, 32, and 40 months postpartum). The relationship between the exposure variable and any change in expressive language score was evaluated using multiple linear regression analysis and growth curve analysis, both adjusted for covariates. Results. Results from the adjusted regression analysis showed that children of mothers with late-onset PPD had significantly lower expressive language scores at 18 months of age and beyond, with a score reduction of approximately 0.6 standard deviations from the reference value at 40 months of age (95%CI:-0.888 to-0.265, p < .001). This association was confirmed on growth curve analysis, which revealed a significant, monotonic decline of expressive language development between 10 and 40 months of age among children of mothers with late-onset PPD, but not among children of mothers with early-onset PPD. Conclusion. Exposure to late-onset PPD may lead to a persistent decline in the rate of expressive language development in offspring during infancy and early childhood, highlighting the significance of monitoring for late-onset PPD to facilitate early detection and intervention.

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Maternal postpartum depressive symptoms predict delay in non-verbal communication in 14-month-old infants

Cited by 27 publications

References 66 publications

The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5

The chronicity and timing of prenatal and antenatal maternal depression and anxiety on child outcomes at age 5

Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development

Peer Review #1 of "Association of late-onset postpartum depression of mothers with expressive language development during infancy and early childhood: the HBC study (v0.1)"

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