Maternal Pre-Pregnancy Body Mass Index and Internalizing and Externalizing Problems in Offspring

Lieshout, Ryan J. Van; Robinson, Monique; Boyle, Michael H.

doi:10.1177/070674371305800305

Cited by 57 publications

(58 citation statements)

References 52 publications

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“…Maternal pre-pregnancy BMI increased the risk of disrupted emotions (e.g., fear and sadness) and has also been associated with increased internalizing behaviors (behaviors associated with withdrawal and depression) in children (Rodriguez, 2010; Van Lieshout et al, 2013). These findings suggest that maternal obesity is involved in the disruption of emotions.…”

Section: Evidence From Human and Animal Studies Indicates That Maternmentioning

confidence: 99%

The role of maternal obesity in the risk of neuropsychiatric disorders

2015

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Recent evidence indicates that perinatal exposure to maternal obesity, metabolic disease, including diabetes and hypertension, and unhealthy maternal diet has a long-term impact on offspring behavior and physiology. During the past three decades, the prevalence of both obesity and neuropsychiatric disorders has rapidly increased. Epidemiologic studies provide evidence that maternal obesity and metabolic complications increase the risk of attention deficit hyperactivity disorder (ADHD), autism spectrum disorders, anxiety, depression, schizophrenia, eating disorders (food addiction, anorexia nervosa, and bulimia nervosa), and impairments in cognition in offspring. Animal models of maternal high-fat diet (HFD) induced obesity also document persistent changes in offspring behavior and impairments in critical neural circuitry. Animals exposed to maternal obesity and HFD consumption display hyperactivity, impairments in social behavior, increased anxiety-like and depressive-like behaviors, substance addiction, food addiction, and diminished cognition. During development, these offspring are exposed to elevated levels of nutrients (fatty acids, glucose), hormones (leptin, insulin), and inflammatory factors (C-reactive protein, interleukin, and tumor necrosis factor). Such factors appear to permanently change neuroendocrine regulation and brain development in offspring. In addition, inflammation of the offspring brain during gestation impairs the development of neural pathways critical in the regulation of behavior, such as serotoninergic, dopaminergic, and melanocortinergic systems. Dysregulation of these circuits increases the risk of mental health disorders. Given the high rates of obesity in most developed nations, it is critical that the mechanisms by which maternal obesity programs offspring behavior are thoroughly characterized. Such knowledge will be critical in the development of preventative strategies and therapeutic interventions.

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Section: Evidence From Human and Animal Studies Indicates That Maternmentioning

confidence: 99%

The role of maternal obesity in the risk of neuropsychiatric disorders

2015

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“…Data from the large cohort studies suggest that maternal pre-pregnancy BMI is also associated with increased risk of internalizing problems, including symptoms of withdrawal, depression, and anxiety in 3–8-year-old children [65,66,67]. Moreover, children born to obese mothers had less rapid decreases in internalizing scores with time, such that internalizing problems identified at 8-years old increased through to age 17 [68]. …”

Section: Human Studiesmentioning

confidence: 99%

A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

Contu

Hawkes

2017

IJMS

129

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Globally, more than 20% of women of reproductive age are currently estimated to be obese. Children born to obese mothers are at higher risk of developing obesity, coronary heart disease, diabetes, stroke, and asthma in adulthood. Increasing clinical and experimental evidence suggests that maternal obesity also affects the health and function of the offspring brain across the lifespan. This review summarizes the current findings from human and animal studies that detail the impact of maternal obesity on aspects of learning, memory, motivation, affective disorders, attention-deficit hyperactivity disorder, autism spectrum disorders, and neurodegeneration in the offspring. Epigenetic mechanisms that may contribute to this mother–child interaction are also discussed.

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“…Furthermore, maternal obesity and consumption of a high-fat diet (HFD) are associated with increased future risk of mental health and neurodevelopmental disorders (5, 6), such as attention-deficit hyperactivity disorder (ADHD) (5, 7, 8) and autism spectrum disorders (ASD) (9–11). Maternal obesity is also associated with childhood affective problems, such as increased risk of fear, sadness, and internalizing behavior (8, 12), and is correlated with low or high birth weight which are linked to anxiety and depression during adolescence (13). Both non-human primate (NHP) and rodent studies demonstrate that chronic maternal HFD consumption produces long-term alterations in offspring’s anxiety-related behaviors (6, 14).…”

Section: Introductionmentioning

confidence: 99%

Exposure to a High-Fat Diet during Early Development Programs Behavior and Impairs the Central Serotonergic System in Juvenile Non-Human Primates

et al. 2017

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Perinatal exposure to maternal obesity and high-fat diet (HFD) consumption not only poses metabolic risks to offspring but also impacts brain development and mental health. Using a non-human primate model, we observed a persistent increase in anxiety in juvenile offspring exposed to a maternal HFD. Postweaning HFD consumption also increased anxiety and independently increased stereotypic behaviors. These behavioral changes were associated with modified cortisol stress response and impairments in the development of the central serotonin synthesis, with altered tryptophan hydroxylase-2 mRNA expression in the dorsal and median raphe. Postweaning HFD consumption decreased serotonergic immunoreactivity in area 10 of the prefrontal cortex. These results suggest that perinatal exposure to HFD consumption programs development of the brain and endocrine system, leading to behavioral impairments associated with mental health and neurodevelopmental disorders. Also, an early nutritional intervention (consumption of the control diet at weaning) was not sufficient to ameliorate many of the behavioral changes, such as increased anxiety, that were induced by maternal HFD consumption. Given the level of dietary fat consumption and maternal obesity in developed nations these findings have important implications for the mental health of future generations.

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Maternal Pre-Pregnancy Body Mass Index and Internalizing and Externalizing Problems in Offspring

Cited by 57 publications

References 52 publications

The role of maternal obesity in the risk of neuropsychiatric disorders

The role of maternal obesity in the risk of neuropsychiatric disorders

A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring

Exposure to a High-Fat Diet during Early Development Programs Behavior and Impairs the Central Serotonergic System in Juvenile Non-Human Primates

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