2020
DOI: 10.1093/cdn/nzaa062_008
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Maternal Pre-Pregnancy Body Mass Index and Gestational Weight Gain Are Associated with Differences in Infant Gut Microbiota: Results from Brazilian Prospective Birth Cohort

Abstract: Objectives To evaluate the association of pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on infant gut microbiota diversity and abundance and the role of breastfeeding on this association. Methods Prospective cohort conducted in Rio de Janeiro, Brazil. Maternal pre-pregnancy BMI (< 25; ≥ 25 kg/m², normal/excessive) and GWG adequacy (adequate; excessive) were the exposures and breastfeeding practi… Show more

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Cited by 4 publications
(3 citation statements)
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“…While our findings were related to the oral cavity, the association between maternal BMI and Veillonella parvula in the gut has been previously reported by Costa and colleagues [48]. It is plausible to consider maternal BMI a proxy variable for child's diet [49].…”
Section: Discussionsupporting
confidence: 58%
“…While our findings were related to the oral cavity, the association between maternal BMI and Veillonella parvula in the gut has been previously reported by Costa and colleagues [48]. It is plausible to consider maternal BMI a proxy variable for child's diet [49].…”
Section: Discussionsupporting
confidence: 58%
“…Predisposition to adiposity may occur in utero, with infants' fecal microbiota profiles being reported to be related to maternal BMI, weight and weight gain during pregnancy [134]. Infants of overweight mothers have been shown to have an altered gut microbiota, with higher levels of Bacteroides, Enterococcus and Staphylococcus over the first six months of life [135,136]. Moreover, feeding has also been reported to influence the prevalence of obesity in childhood, with infants who are breastfed being less likely to develop obesity than their formula-fed counterparts [137].…”
Section: Obesitymentioning
confidence: 99%
“…Recently, increasing evidence have shown the impacts of pre-natal maternal factors on infant gut microbiota through the transmission of metabolic diseases passed from mother to child. The maternal factors are primarily associated with physical health before and during pregnancy as indicated by high pre-pregnancy body mass index (BMI) (6)(7)(8), unhealthy weight gain (6,8), maternal exposure to medications (7)(8)(9)(10), and gestational diabetes mellitus (GDM) (7,8,11). Furthermore, environmental factors involving maternal diet, including highfat diet (7,8,12), smoking (10,13), and food insecurity (14) during pregnancy are linked to the changes in infant gut microbiota.…”
Section: Introductionmentioning
confidence: 99%