Maternal pre-pregnancy underweight is associated with underweight and low bone mass in school-aged children

Fujita, Yuki; Kouda, Katsuyasu; Nakamura, Harunobu; Iki, Masayuki

doi:10.1007/s00774-020-01121-1

Cited by 4 publications

(3 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies assessed the possible link between maternal prepregnancy weight and offspring BMD ( Table 7 ). In three of them, authors found no association [ 57 , 58 , 59 ], whereas Rudang et al [ 54 ] found a positive association.…”

Section: Findings and Discussionmentioning

confidence: 99%

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

View full text Add to dashboard Cite

There is growing evidence that bone health may be programmed in the first years of life. Factors during the prenatal period, especially maternal nutrition, may have an influence on offspring’s skeletal development and thus the risk of osteoporosis in further life, which is an increasing societal, health and economic burden. However, it is still inconclusive which early life factors are the most important and to what extent they may affect bone health. We searched through three databases (PubMed, Google Scholar, Cochrane Library) and after eligibility criteria were met, the results of 49 articles were analyzed. This narrative review is an overall summary of up-to-date studies on maternal diet, nutritional status, and birth-related factors that may affect offspring bone development, particularly bone mineral density (BMD). Maternal vitamin D status and diet in pregnancy, anthropometry and birth weight seem to influence BMD, however other factors such as subsequent growth may mediate these associations. Due to the ambiguity of the results in the analyzed studies, future, well-designed studies are needed to address the limitations of the present study.

show abstract

Section: Findings and Discussionmentioning

confidence: 99%

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

2021

View full text Add to dashboard Cite

show abstract

“…The present study was a population-based retrospective cohort study which targeted adolescents enrolled in the Japan Kids Body-composition Study (JKB Study) [ 12 ]. The source population was 800 children aged 13–14 years who were registered at Shiokawa Junior High School in 2010, 2013, and 2016, and at Sekishi Junior High School in 2013 and 2014 in Hamamatsu, Japan.…”

Section: Methodsmentioning

confidence: 99%

Infant weight gain and DXA-measured adolescent adiposity: data from the Japan Kids Body-composition Study

Fujita

Kouda

Nakamura

et al. 2021

J Physiol Anthropol

Self Cite

View full text Add to dashboard Cite

Background Rapid weight gain in early life is associated with adiposity later in life. However, there is limited information on the association between weight gain and body fat mass measured using precise methods. This study aimed to investigate whether weight gain is associated with body fat mass measured by dual-energy X-ray absorptiometry (DXA) in adolescents. Methods Participants of this retrospective cohort study were 423 adolescents born at full-term who were enrolled in the Japan Kids Body-composition Study. Anthropometric measurements related to pregnancy, delivery, and child health were obtained from the Japanese Maternal and Child Health Handbook. Fat mass in adolescents was measured with a DXA scanner. Weight gain was defined as the change in body weight from birth to age 1.5 years. Associations between birthweight and fat mass, and between weight gain and fat mass, were evaluated using multiple regression analysis. Results There was a significant positive association between weight gain from birth to age 1.5 years and fat mass in adolescents (boys: standardized regression coefficient (β) = 0.253, p < 0.01; girls: β = 0.246, p < 0.01), but not between birthweight standardized for gestational age and fat mass. Conclusion Children with a greater change in weight from birth to age 1.5 years tended to have increased fat mass in adolescence. Weight gain in early life has a greater impact on fat mass in adolescents than birthweight.

show abstract

“…Similarly, in a cohort study in Japan, children born to underweight mothers had lower WBLH BMC and BA, but similar BMD, at age 10 years. However, it is probable that this was mediated by offspring weight, which may also have shared genetic and environmental origins in mother and child [ 53 ]. Indeed, there is likely a non-linear relationship between maternal body habitus and offspring bone development, but there is stronger evidence to support a role for dietary quality and components affecting offspring bone health.…”

Section: Maternal Body Habitus and Offspring Bone Healthmentioning

confidence: 99%

Early Life Programming of Skeletal Health

Moon,

Citeroni,

Aihie

et al. 2023

Curr Osteoporos Rep

View full text Add to dashboard Cite

Purpose of Review Increasing bone mineral accrual during childhood might delay the onset of osteoporosis. We discuss the scientific evidence for early life approaches to optimising skeletal health. Recent Findings There is an ever-growing body of evidence from observational studies suggesting associations between early life exposures, particularly during foetal development, and bone mineral density (BMD). The findings of such studies are often heterogeneous, and for some exposures, for example, maternal smoking and alcohol intake in pregnancy or age at conception, intervention studies are not feasible. The most frequently studied exposures in intervention studies are calcium or vitamin D supplementation in pregnancy, which overall suggest positive effects on offspring childhood BMD. Summary Maternal calcium and/or vitamin D supplementation during pregnancy appear to have positive effects on offspring BMD during early childhood, but further long-term follow-up is required to demonstrate persistence of the effect into later life.

show abstract

Maternal pre-pregnancy underweight is associated with underweight and low bone mass in school-aged children

Cited by 4 publications

References 33 publications

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

Maternal Diet, Nutritional Status, and Birth-Related Factors Influencing Offspring’s Bone Mineral Density: A Narrative Review of Observational, Cohort, and Randomized Controlled Trials

Infant weight gain and DXA-measured adolescent adiposity: data from the Japan Kids Body-composition Study

Early Life Programming of Skeletal Health

Contact Info

Product

Resources

About