Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity

Özkan, Hilal; Çetınkaya, Merih; Köksal, Nilgün; Özmen, Ahmet; Yıldız, Meral

doi:10.1515/jpm.2011.071

Cited by 42 publications

(50 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although we and other authors 14,27,28 found a detrimental role played by hypertension on ROP, others showed a protective one. [29][30][31] A possible explanation for these discordant results lies in the data analysis.…”

Section: Figurecontrasting

confidence: 65%

“…If being SGA is both caused by hypertension/preeclampsia and associated with ROP, then adjusting for birth weight in studies analyzing the role of hypertensive disorders could give rise to a problem of "overadjustment." In fact, studies that investigate the role played by hypertension on ROP and correct-for-birth weight in their analysis find that hypertension is protective, [28][29][30] whereas others that do not adjust (eg, this study and refs 14,27,28) find the opposite.…”

Section: Figurementioning

confidence: 70%

“…In addition, it shows how for in-hospital mortality the relationship between the relative exposures and the outcome is not constant, even in the small GA strata considered in this study (23)(24)(25)(26)(27)(28)(29)(30) weeks' GA).…”

Section: Discussionmentioning

confidence: 81%

See 2 more Smart Citations

Association of Maternal Hypertension and Chorioamnionitis With Preterm Outcomes

et al. 2014

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: In very preterm infants, outcomes depend not only on the degree of immaturity, but also on the underlying pathologies that trigger preterm delivery. Studies that have addressed this issue have provided unclear results.WHAT THIS STUDY ADDS: Patterns of outcomes differ between maternal hypertension and chorioamnionitis: hypertension is associated with greater risks for bronchopulmonary dysplasia and retinopathy of prematurity, and lower risks for brain injury, necrotizing enterocolitis, early-onset sepsis. For mortality, the effect changes across gestational age weeks. abstract OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS:A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS:Overall mortality was higher after hypertension than after chorioamnionitis (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.08-1.80), but this relationship changed across GA weeks; the OR for hypertension was highest at low GA, whereas from 28 weeks' GA onward, mortality was higher for chorioamnionitis. For other outcomes, the relative risks were constant across GA; infants born after hypertension had an increased risk for bronchopulmonary dysplasia (OR, 2.20; 95% CI, 1.68-2.88) and severe retinopathy of prematurity (OR, 1.48; 95% CI, 1.02-2.15), whereas there was a lower risk for earlyonset sepsis (OR, 0.25; 95% CI,, severe intraventricular hemorrhage (OR, 0.65; 95% CI, periventricular leukomalacia (OR, 0.70; 95% CI,, and surgical necrotizing enterocolitis or gastrointestinal perforation (OR, 0.47; 95% CI, 0.31-0.72).CONCLUSIONS: Mortality and other adverse outcomes in very preterm infants depend on antecedents of preterm birth. Hypertension and chorioamnionitis are associated with different patterns of outcomes; for mortality, the effect changes across GA weeks. Pediatrics 2014;134:e154-e161 AUTHORS:

show abstract

Section: Figurecontrasting

confidence: 65%

Section: Figurementioning

confidence: 70%

See 1 more Smart Citation

Association of Maternal Hypertension and Chorioamnionitis With Preterm Outcomes

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The category of HDP was consistent among studies. Ten studies reported preeclampsia [5,10,13–18,20–21], two reported gestational hypertension [16,20], and two reported HDP [8–9]. Outcomes were categorized as 2 broad categories: “any stage ROP” and “severe ROP”.…”

Section: Resultsmentioning

confidence: 99%

Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis

et al. 2017

View full text Add to dashboard Cite

BackgroudThe role of maternal hypertensive disorders in pregnancy (HDP) in the development of retinopathy of prematurity (ROP) is unclear.MethodsStudies were retrieved through literature searches in PubMed, EMBASE, Web of Science and the Cochrane Library up to May 5, 2016 without language restrictions. Cohort or case–control studies that reported the association of maternal hypertensive disorders and retinopathy of prematurity were eligible. Either a fixed- or a random-effects model was used to calculate the overall combined risk estimates.ResultsThirteen cohort studies involving a total of 45082 individuals were included in the review. The pooled odds ratios of maternal hypertensive disorders in pregnancy for any stage and severe stages of ROP was 1.12 (95%CI: 0.90–1.40) and 0.80 (95%CI: 0.47–1.35), respectively. Sensitivity analyses confirmed that no single study qualitatively influenced the pooled OR. However, substantial heterogeneity and publication bias were observed in the meta-analysis.ConclusionsAdditional larger, prospective and well-adjusted studies are needed to determine the association between HDP and ROP, especially regarding the effects of different types of maternal hypertensive disorders in pregnancy on retinopathy of prematurity.

show abstract

“…Worldwide hypertensive Disorder of Pregnancy (HDP) affects around 10% of all pregnancies with pre-eclampsia and eclampsia together accounting for 10-15% of all direct maternal deaths 1 and major burden of perinatal morbidity and mortality [6][7][8][9] . There is worldwide regional variation in distribution of maternal deaths due to HDP with 16.1% occurring in developed countries, 9.1% in Africa, 9.1% in Asia, and around 25.7% in Latin America and the Caribbean 2 .…”

mentioning

confidence: 99%

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Kumar¹,

Singh²

2018

OBGYN

View full text Add to dashboard Cite

Objectives: Assess relationship between maternal serum calcium levels, severity of disease and overall perinatal and maternal outcome in women with hypertensive disorders of pregnancy. Methods: Present prospective cross sectional study was conducted in the Obstetrics and Gynaecology department of rural tertiary care centre of Northern India after proper Institution ethical committee approval and informed written consent from the participants over a period of seven months (October 2016-May 2017. A total of 110 childbearing women admitted at ≥34 weeks of gestation were divided into three groups; Gestational hypertension (n=35), Preeclampsia (n=49) and Eclampsia (n=26). Maternal serum calcium levels and its correlation with severity of disease and overall maternal and perinatal outcome were assessed in each group. Results: Of 110 childbearing women, cases with gestational hypertension had mean serum calcium 8.83 ± 0.55 mg/dl, in pre-eclampsia 8.55 ± 0.89 mg/dl and in eclampsia group 8.41 ± 0.76 mg/dl. Of total 66 term births, 31(88.57%) occurred in gestational hypertension group, 26(53.06%) in pre-eclampsia and 8(30.77%) in eclampsia group. Maximum maternal and perinatal morbidity and mortalities were observed in women with eclampsia having minimum serum calcium levels followed by pre-eclampsia and least in women with gestational hypertension having near normal serum calcium levels. Conclusion: Significant correlation was observed between maternal serum calcium and severity of hypertensive disorder of pregnancy, adverse perinatal and maternal outcome.Keywords: Blood pressure, calcium, hypertension, pregnancy, perinatal.Hypertension during pregnancy with or without proteinuria is one of the leading causes of maternal and perinatal morbidity and mortality all over the world 1-4 , accounting for more than 40,000 maternal deaths annually 5 . Worldwide hypertensive Disorder of Pregnancy (HDP) affects around 10% of all pregnancies with pre-eclampsia and eclampsia together accounting for 10-15% of all direct maternal deaths 1 and major burden of perinatal morbidity and mortality 6-9 . There is worldwide regional variation in distribution of maternal deaths due to HDP with 16.1% occurring in developed countries, 9.1% in Africa, 9.1% in Asia, and around 25.7% in Latin America and the Caribbean 2 .Till date the only proven way to prevent development as well as severity of HDP is calcium supplementation 1 .Calcium supplementation during pregnancy is known to decrease incidence as well as severity of gestational hypertension, pre-eclampsia, eclampsia and also neonatal RESEARCH ARTICLE

show abstract

Maternal preeclampsia is associated with an increased risk of retinopathy of prematurity

Abstract: Maternal preeclampsia was found to be associated with increased ROP development risk in premature infants. ROP was also more severe in infants born to pre-eclamptic mothers. The role of maternal preeclampsia in the occurrence and severity of ROP remains to be elucidated.

Cited by 42 publications

References 25 publications

Association of Maternal Hypertension and Chorioamnionitis With Preterm Outcomes

Association of Maternal Hypertension and Chorioamnionitis With Preterm Outcomes

Association of maternal hypertensive disorders with retinopathy of prematurity: A systematic review and meta-analysis

Impact of maternal serum calcium levels on severity of hypertensive disorder of pregnancy: A cross sectional study

Contact Info

Product

Resources

About