Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.

O’Connor, Thomas G.; Ciesla, Allison Avrich; Sefair, Ana Vallejo; Thornburg, Loralei L.; Brown, Alan S.; Glover, Vivette; O’Donnell, Kieran J.

doi:10.1037/abn0000746

Cited by 22 publications

(16 citation statements)

References 77 publications

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“…These results support those of previous studies of acetaminophen use in pregnancy and child neurodevelopmental and behavioral outcomes, which reported the confounding effect of prenatal alcohol consumption [ 3 – 6 ]. Furthermore, previous studies have found an association between maternal infection and child development including an increased risk for autism spectrum disorders [ 42 , 43 ], social and communication problems [ 44 ], and emotional symptoms [ 45 ]. However findings have been inconsistent and some studies have not found an association, which may be due to differences in the covariates included in the models, the severity of infection [ 46 ], and differences in trimester of infection [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

2022

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Background Acetaminophen is one of the most commonly used drugs during pregnancy globally. Recent studies have reported associations between prenatal exposure to acetaminophen and neurobehavioral problems in children, including attention-deficit hyperactivity disorders. Little research has investigated these associations in preschool-age children or the potential confounding effects of prenatal stress. The purpose of this study was to examine associations between prenatal acetaminophen exposure and offspring neurobehavioral problems at the age of 3 years, with a focus on the potentially confounding effects of prenatal stress. Methods We used data from the First Baby Study, a prospective cohort study conducted in Pennsylvania, USA, with 2,423 mother-child pairs. Women reported medication use and completed a prenatal stress inventory during their third trimester. Child behavioral problems were measured at the age of 3 years, using the 7 syndrome scale scores from the Child Behavior Checklist (CBCL) for ages 1 ½ to 5. Results There were 1,011 women (41.7%) who reported using acetaminophen during pregnancy. Children who were exposed to acetaminophen during pregnancy scored significantly higher on 3 of the 7 CBCL syndrome scales: withdrawn, sleep problems and attention problems. Scores on all 7 of the CBCL syndrome scales were significantly associated with prenatal stress. After adjustment for prenatal stress and other confounders, 2 syndrome scales remained significantly higher in children exposed to acetaminophen: sleep problems (aOR = 1.23, 95% CI = 1.01–1.51) and attention problems (aOR = 1.21, 95% CI = 1.01–1.45). Conclusions These findings corroborate previous studies reporting associations between prenatal exposure to acetaminophen and attention problems in offspring and also show an association with sleep problems at age 3 years. Because use of acetaminophen during pregnancy is common, these results are of public health concern and suggest caution in the use of medications containing acetaminophen during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

2022

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“…Previous studies demonstrate the robustness of the association between the level of salivary cortisol and the level of stress during pregnancy at different gestational ages [ 49 ]. These authors emphasize the importance of the salivary cortisol level, which can be an important predictor of child outcome because it may be the best indicator of HPA axis disturbances caused by maternal stress [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Psychological Suffering, Value of Maternal Cortisol during Third Trimester of Pregnancy and Breastfeeding Initiation

et al. 2023

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Background and Objectives: Cortisol, the stress hormone, is an important factor in initiating and maintaining lactation. Maternal suffering during pregnancy is predictive for the initiation and shorter duration of breastfeeding and can also lead to its termination. The aim of this study is to evaluate the relationship between the level of salivary cortisol in the third trimester of pregnancy and the initiation of breastfeeding in the postpartum period in a cohort of young pregnant women who wanted to exclusively breastfeed their newborns during hospitalization. Materials and Methods: For the study, full-term pregnant women were recruited between January and May 2022 in the Obstetrics and Gynecology Clinic of the Mureș County Clinical Hospital. Socio-demographic, clinical obstetric and neonatal variables were collected. Breastfeeding efficiency was assessed using the LATCH Breastfeeding Assessment Tool at 24 and 48 h after birth. The mean value of the LATCH score assessed at 24 and 48 h of age was higher among mothers who had a higher mean value of salivary cortisol measured in the third trimester of pregnancy (p < 0.05). A multivariate logistic regression model was used to detect risk factors for the success of early breastfeeding initiation. Results: A quarter of pregnant women had a salivary cortisol level above normal limits during the third trimester of pregnancy. There is a statistically significant association between maternal smoking, alcohol consumption during pregnancy and the level of anxiety or depression. Conclusion: The most important finding of this study was that increased salivary cortisol in the last trimester of pregnancy was not associated with delayed initiation/absence of breastfeeding.

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“…Maternal prenatal psychological distress, which includes depression symptoms and anxiety, has been found to affect the offspring's neurodevelopment, including motor and cognitive development, temperament, and mental health through effects on the developing fetus; a process commonly known as the Developmental Origins of Health and Disease hypothesis. [1][2][3][4][5][6][7][8][9][10][11][12] The impact of maternal psychological distress during pregnancy on offspring development can depend on the offspring's developmental age and sex; however, research results in this regard remain inconsistent. There are also inconsistent findings regarding the periods of pregnancy during which maternal psychological distress has the greatest impact on the offspring.…”

Section: Introductionmentioning

confidence: 99%

Maternal prenatal psychological distress and motor/cognitive development in two-year-old offspring: The Japan Environment and Children’s Study

Mori

Nishigori²,

Ogata³

et al. 2023

J Dev Orig Health Dis

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Maternal prenatal psychological distress, including depression and anxiety, may affect offspring’s motor/cognitive development. However, research findings have been inconsistent. We used a dataset from the Japan Environment and Children’s Study to evaluate associations between maternal six-item Kessler Psychological Distress Scale (K6) scores and motor/cognitive development among offspring at two years of age. Their offspring’s motor/cognitive development was assessed using the Kyoto Scale of Psychological Development 2001. Records for 1859 male and 1817 female offspring were analyzed. The maternal K6 was administered twice during pregnancy: at a median of 14.6 weeks (M-T1) and 27.3 weeks (M-T2) of gestation. Multiple regression analysis was performed with the group with K6 scores ≤4 at both M-T1 and M-T2 as a reference. In the group with K6 scores ≥5 at both M-T1 and M-T2, male offspring had significantly lower developmental quotients (DQ) in the posture-motor area (partial regression coefficient [B]: −3.68, 95% confidence interval [CI]: −5.92 to −1.44) and language-social area (B: −1.93; 95%CI: −3.73 to −0.12), while female offspring had a lower DQ for the language-social area (B: −1.95; 95%CI: −3.73 to −0.17). In those with K6 scores ≥5 only at M-T1 or M-T2, male and female offspring did not differ significantly in DQ for any area. Continuous maternal psychological distress from the first to the second half of pregnancy was associated with lower motor and verbal cognitive development in male offspring and lower verbal cognitive development in female offspring at 2 years compared with the group without persistent maternal prenatal psychological distress.

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Maternal prenatal infection and anxiety predict neurodevelopmental outcomes in middle childhood.

Cited by 22 publications

References 77 publications

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

Maternal use of acetaminophen during pregnancy and neurobehavioral problems in offspring at 3 years: A prospective cohort study

The Relationship between Psychological Suffering, Value of Maternal Cortisol during Third Trimester of Pregnancy and Breastfeeding Initiation

Maternal prenatal psychological distress and motor/cognitive development in two-year-old offspring: The Japan Environment and Children’s Study

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