Maternal prenatal plasma oxytocin is positively associated with prenatal psychological symptoms, but method of immunoassay extraction may affect results

Saxbe, Darby; Khaled, Mona; Horton, Katelyn; Mendez, Armando J.

doi:10.1016/j.biopsycho.2019.107718

Cited by 35 publications

(32 citation statements)

References 50 publications

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“…Discrepancies between methods are not necessarily an indicator that some methods are valid whereas others are not the usefulness in predicting behavior based on blood levels of OT taken from unextracted J o u r n a l P r e -p r o o f samples are contradicted by more recent research. For example, two recent studies show that unextracted samples are more likely to show associations with behavior (Chu et al, 2020;Saxbe et al, 2019). Our experience with assays in unextracted plasma indicates reliable and replicable relationships between peripheral measures of OT and behavior, even in analyses done several years apart (see for example, Lancaster et al, 2015).…”

Section: Oxytocin Assaysmentioning

confidence: 66%

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The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study

Roels

Rehman

Carter

et al. 2021

Psychoneuroendocrinology

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Section: Oxytocin Assaysmentioning

confidence: 66%

“…It should be noted that the relationship between behavior and plasma OT was stronger in data from studies yielding higher levels of OT, as is the case in Chu, et al, (2020) and Saxbe, et al, (2019).…”

Section: Discussionmentioning

confidence: 93%

The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study

Roels

Rehman

Carter

et al. 2021

Psychoneuroendocrinology

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“…Of the MRI sample, nine fathers with oxytocin (27% of the sample) had oxytocin levels below detection levels following extraction, similar to prior research analyzing extracted oxytocin (e.g., Szeto et al, 2011; Tabak et al, 2011). Consistent with prior work, we assigned a value of 0.4 pg/ml to samples below the detection level (Saxbe et al, 2019).…”

Section: Methodsmentioning

confidence: 92%

Theory of mind processing in expectant fathers: Associations with prenatal oxytocin and parental attunement

Cardenas

Stoycos

Sellery

et al. 2021

Developmental Psychobiology

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Social cognition may facilitate fathers' sensitive caregiving behavior. We administered the Why‐How Task, an fMRI task that elicits theory of mind processing, to expectant fathers (n = 39) who also visited the laboratory during their partner's pregnancy and provided a plasma sample for oxytocin assay. Three months postpartum, fathers reported their beliefs about parenting. When rating “Why” an action was being performed versus “How” the action was being performed (Why > How contrast), participants showed activation in regions theorized to support theory of mind, including the dorsomedial prefrontal cortex and superior temporal sulcus. Fathers' prenatal oxytocin levels predicted greater signal change during the Why > How contrast in the inferior parietal lobule. Both prenatal oxytocin and attunement parenting beliefs were associated with Why > How activation in the dorsolateral prefrontal cortex, a theory of mind region implicated in emotion regulation. Posterior parahippocampal gyrus and dorsolateral prefrontal cortex activation during the Why > How contrast predicted fathers' attunement parenting beliefs. In conclusion, fathers' neural activation when engaging in a theory of mind task was associated with their prenatal oxytocin levels and their postpartum attunement parenting beliefs. Results suggest biological and cognitive components of fathering may track with the theory of mind processing.

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“…While there is concern about the state of intranasal OT research that is leading some to lose “trust” in published findings [ 35 ], expanding the set of behaviors that intranasal OT influences, as we have done here, adds value to this evolving literature. In a similar vein, research measuring endogenous OT was affected by calls to dismiss findings from unextracted assays (e.g., [ 81 – 83 ]) that is being re-evaluated with a better understanding of OT measurement [ 84 ], extraction methods, and how to associate the change in OT with social behaviors (e.g., [ 85 , 86 ]. Extension and replication are essential for both intranasal OT studies and endogenous OT measurement studies.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin increases perceived competence and social-emotional engagement with brands

Barraza

Terris

et al. 2021

PLoS ONE

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Humans express loyalty to consumer brands much like they do in human relationships. The neuroactive chemical oxytocin is an important biological substrate of human attachment and this study tested whether consumer-brand relationships can be influenced by oxytocin administration. We present a mathematical model of brand attachment that generates empirically-testable hypotheses. The model is tested by administering synthetic oxytocin or placebo to male and female participants (N = 77) who received information about brands and had an opportunity to purchase branded products. We focused on two brand personality dimensions: warmth and competence. Oxytocin increased perceptions of brand competence but not brand warmth relative to placebo. We also found that participants were willing to pay more for branded products through its effect on brand competence. When writing about one’s favorite brands, oxytocin enhanced the use of positive emotional language as well as words related to family and friends. These findings provide preliminary evidence that consumers build relationships with brands using the biological mechanisms that evolved to form human attachments.

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Maternal prenatal plasma oxytocin is positively associated with prenatal psychological symptoms, but method of immunoassay extraction may affect results

Cited by 35 publications

References 50 publications

The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study

The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study

Theory of mind processing in expectant fathers: Associations with prenatal oxytocin and parental attunement

Oxytocin increases perceived competence and social-emotional engagement with brands

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