Maternal prenatal stress in rats influences c-fos expression in the spinal cord of the offspring

Zouhairi, Nadia; Ba‐M’hamed, Saadia; Bennis, Mohamed

doi:10.1016/j.acthis.2011.09.006

Cited by 2 publications

(4 citation statements)

References 72 publications

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“…Psychopathological consequences of PS in later life, together with animal models (Viltart et al, 2006) and the parallelism of early changes in c-FOS protein and SERT and TPH2 mRNA (Bethea et al, 2013) led us to infer that PS would impact the long-term expression of both c-FOS and SERT protein as well as related mRNAs in the PS offspring. Using an established model of auditory PS in stresssensitive BALB/c mice (Pincus-Knackstedt et al, 2006), but without confounding postnatal behavioral tests (Zouhairi et al, 2012), our findings support the initial hypothesis drawn from the higher baserate of Fos-immuno-reactive neurons in PS rodents (Viltart et al, 2006). In particular, we report a PS-induced increase in protein expression of c-FOS paralleled with higher levels of SERT in the STR and HPC of young adult mammals.…”

Section: Discussionsupporting

confidence: 85%

“…Studying potential mechanisms in animals, short-term effects of PS have been associated with lower immediate early gene FOS in the fetal paraventricular nucleus of the hypothalamus (HYP) (Tobe et al, 2005), and serotonin transporter (SERT) in fetal hippocampus (HPC) or HPY (Huang et al, 2012). In contrast, neuronal FOS-expression has been found to be increased among PS offspring in later life, suggesting a hyper-responsiveness upon stimulation when compared to controls (Zouhairi et al, 2012). However, despite the relevance of SERT for the majority of PS-related psychiatric disorders in the later human life, data on long-term PS effects in animal models are lacking.…”

Section: Introductionmentioning

confidence: 99%

“…brain derived nerve growth factor (BDNF), were found to be altered due to sex and elapsed time (Zuena et al, 2008). Moreover, PS intensity in animal models can cause contrasting changes of epigenetic modifications and behavioral aspects (Mychasiuk et al, 2011 environment, may be biased by rather intense PS and are often combined with postnatal behavioral tests to challenge the response under stressful conditions (Zouhairi et al, 2012). The present study aimed to verify the insights from previous animal studies by avoiding such biases and to rule out any potential additive or interactive effect of PS-by-sex (PS × sex) on gene and protein expression.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal stress increases the striatal and hippocampal expression of correlating c‐FOS and serotonin transporters in murine offspring

Bielas

Arck

Bruenahl

et al. 2014

Intl J of Devlp Neuroscience

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Prenatal stress (PS) is a known risk factor for several psychiatric diagnoses, including schizophrenia, attention deficit hyperactivity disorder, autism, anxiety, and depression which have been associated with serotonin transporter (SERT) dysregulation. Moreover, long-term effects in animal models associate with higher levels of immediate early genes, e.g. c-FOS (up-regulated in response to neuronal activity), in the brain of PS offspring. We therefore quantified the expression of both protein related mRNAs in adolescent BALB/c mice subjected to mild auditory stress on two separate days in mid gestation. SERT and c-FOS consistently correlated in most brain regions of PS mice and controls. Moreover, two-way ANOVAs revealed concomitantly increased levels of proteins, as well as of FOSL1 and FOSL2 mRNA, especially in the striatum and hippocampus of the PS offspring. Sex affected only and less consistently mRNA expression, yet interacted with PS, demonstrating that glucocorticoid receptor mRNA expression decreased in PS males but increased in PS females compared to the respective controls. This first finding of a correlation between SERT and c-FOS protein expression affected by PS, together with related mRNAs, may be considered a new target for behavioral and treatment studies in offspring.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal stress increases the striatal and hippocampal expression of correlating c‐FOS and serotonin transporters in murine offspring

Bielas

Arck

Bruenahl

et al. 2014

Intl J of Devlp Neuroscience

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show abstract

“…EA stimuli were delivered by an EA Trio 300 stimulator (Ito, Japan) at 1 mA intensities for a 15 min duration at a frequency of 2, 50, or 100 Hz, with a pulse width of 150 μ s. The two electrodes were connected to the needles, which were inserted into GV20 and GV14. In the control group, animals were also covered by paraffin film and restrained by tape for 15 min [44]. A sham EA was performed by bilateral insertion of a pair of stainless steel acupuncture needles approximately 3-4 mm deep into the middle of each scapula, which is equivalent to the human Tianzong (SI11).…”

Section: Methodsmentioning

confidence: 99%

Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice

Chen

Ivanic

Chuang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The aims of this study were to characterize the protective profile of electroacupuncture (EA) on cocaine-induced seizures and mortality in mice. Mice were treated with EA (2 Hz, 50 Hz, and 100 Hz), or they underwent needle insertion without anesthesia at the Dazhui (GV14) and Baihui (GV20) acupoints before cocaine administration. EA at 50 Hz applied to GV14 and GV20 significantly reduced the seizure severity induced by a single dose of cocaine (75 mg/kg; i.p.). Furthermore, needle insertion into GV14 and GV20 and EA at 2 Hz and 50 Hz at both acupoints significantly reduced the mortality rate induced by a single lethal dose of cocaine (125 mg/kg; i.p.). In the sham control group, EA at 50 Hz applied to bilateral Tianzong (SI11) acupoints had no protective effects against cocaine. In addition, EA at 50 Hz applied to GV14 and GV20 failed to reduce the incidence of seizures and mortality induced by the local anesthetic procaine. In an immunohistochemistry study, EA (50 Hz) pretreatment at GV14 and GV20 decreased cocaine (75 mg/kg; i.p.)-induced c-Fos expression in the paraventricular thalamus. While the dopamine D3 receptor antagonist, SB-277011-A (30 mg/kg; s.c), did not by itself affect cocaine-induced seizure severity, it prevented the effects of EA on cocaine-induced seizures. These results suggest that EA alleviates cocaine-induced seizures and mortality and that the dopamine D3 receptor is involved, at least in part, in the anticonvulsant effects of EA in mice.

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Maternal prenatal stress in rats influences c-fos expression in the spinal cord of the offspring

Cited by 2 publications

References 72 publications

Prenatal stress increases the striatal and hippocampal expression of correlating c‐FOS and serotonin transporters in murine offspring

Prenatal stress increases the striatal and hippocampal expression of correlating c‐FOS and serotonin transporters in murine offspring

Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice

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