Maternal prenatal stress is associated with the infant intestinal microbiota

Zijlmans, Maartje A.C.; Korpela, Katri; Riksen‐Walraven, J. Marianne; Vos, Willem M. de; Weerth, Carolina de

doi:10.1016/j.psyneuen.2015.01.006

Cited by 382 publications

(337 citation statements)

References 50 publications

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“…Consistent with our hypothesis, maternal stress altered proteins related to vaginal immunity and abundance of Lactobacillus, the prominent taxon in the maternal vagina and an important primary colonizer of the neonate gut [108]. These results add to a growing number of studies in rodent models, primates and humans demonstrating that maternal stress decreases Lactobacillus abundance in neonates, suggesting the possibility that the mechanisms by which stress alters Lactobacillus are conserved [71,109,110,[127][128][129]. Further, loss of maternal vaginal Lactobacillus also resulted in decreased transmission of this bacterium to EPS-exposed offspring, which may disrupt the ability of the offspring gut to perform critical functions such as fermenting breast milk lactose and casein, producing lactic acid and maintaining an acidic intestinal environment during early development [130][131][132].…”

Section: (B) Postnatalsupporting

confidence: 81%

Sex differences in the gut microbiome–brain axis across the lifespan

Jašarević

Morrison

Bale

2016

Phil. Trans. R. Soc. B

231

167

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In recent years, the bidirectional communication between the gut microbiome and the brain has emerged as a factor that influences immunity, metabolism, neurodevelopment and behaviour. Cross-talk between the gut and brain begins early in life immediately following the transition from a sterile in utero environment to one that is exposed to a changing and complex microbial milieu over a lifetime. Once established, communication between the gut and brain integrates information from the autonomic and enteric nervous systems, neuroendocrine and neuroimmune signals, and peripheral immune and metabolic signals. Importantly, the composition and functional potential of the gut microbiome undergoes many transitions that parallel dynamic periods of brain development and maturation for which distinct sex differences have been identified. Here, we discuss the sexually dimorphic development, maturation and maintenance of the gut microbiome–brain axis, and the sex differences therein important in disease risk and resilience throughout the lifespan.

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Section: (B) Postnatalsupporting

confidence: 81%

Sex differences in the gut microbiome–brain axis across the lifespan

Jašarević

Morrison

Bale

2016

Phil. Trans. R. Soc. B

231

167

View full text Add to dashboard Cite

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“…However, it must also be noted that the microbialneuroendocrine relationship is bi-directional as stress can change the composition of the gut microbiota. This is true of early-life stress (Bailey and Coe, 1999;O'Mahony et al, 2009) prenatal stress (Golubeva et al, 2015a;Jasarevic et al, 2015;Zijlmans et al, 2015) and psychological stress (Bailey et al, 2011;Bharwani et al, 2016;Galley et al, 2014;Reber et al, 2016) As outlined above and elsewhere in this issue, glucocorticoids modulate the expression of TDO (O'Farrell and Harkin, 2015;O'Mahony et al, 2015). As such, TDO activity may at least partly be contingent on a microbial-neuroendocrine interplay with significant implications for brain function and behaviour.…”

Section: Tryptophan Metabolism Serotonin and The Kynurenine Pathwaymentioning

confidence: 99%

Kynurenine pathway metabolism and the microbiota-gut-brain axis

et al. 2017

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“…Higher levels of reported PNS are associated with preterm birth, lower birth weight (Dunkel Schetter & Tanner, 2012;Shapiro, Fraser, Frasch, & Seguin 2013), obesity, metabolic dysfunction (Entringer, 2013), and more illnesses, and antibiotic treatments (Beijers, Jansen, Riksen-Walraven, & de Weerth, 2010). Higher PNS, as assessed with maternal prenatal cortisol concentrations, is also associated with offspring health (Zijlmans Korpela, Riksen-Walraven, de Vos, & de Weerth, 2015), including lower birth weight (Bolten et al, 2011;D'Anna-Hernandez et al, 2012;Goedhart et al, 2010), shorter gestational age (Diego et al, 2009;Erickson et al, 2001;Mercer et al, 2006), more infant respiratory and skin illnesses (Beijers et al, 2010), and larger systemic vascular resistance and lower artery elasticity (Rond o, Lemos, Pereira, & Souza, 2010;Rond o, Pereira, Lemos, & Ferreira, 2011). However, most studies on the relation between PNS and physical health in offspring focused on early life.…”

Section: Introductionmentioning

confidence: 99%

Maternal late pregnancy anxiety and stress is associated with children’s health: a longitudinal study

Zijlmans

Beijers

Riksen-Walraven

et al. 2017

Stress

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Aim: Maternal prenatal anxiety and stress (PNS) have been positively associated to physical health prob lems in offspring in the first year of life. Whether these associations are transient, persistent, or even progressive over time, is as yet unknown. The goal of this study is to investigate associations between late pregnancy PNS and child health from 18 months to age 6. Methods: Mothers were recruited in late pregnancy, and had uncomplicated, singleton pregnancies without physical health problems. Around week 37 of pregnancy, mothers reported on their PNS by means of questionnaires, and provided saliva for determination of circadian cortisol concentrations. Children's illnesses in the preceding year were assessed using maternal reports at 30, 48, 60, and 72 months. Antibiotic use was obtained from medical records between one and six years. Multilevel models (N 1 =4174) showed a positive relation between maternal prenatal general and pregnancy-specific anxiety during late pregnancy and offspring respiratory illnesses and symptoms. Interaction effects with time indicated that more PNS was related to more respiratory illnesses until toddlerhood, but not later in life. Furthermore, maternal prenatal cortisol concentrations were related to child digestive illnesses. A steeper maternal cortisol decline over the day was related to more child digestive illnesses, until around three years of age. Finally, children of mothers who suffered more from daily hassles during pregnancy received more antibiotics between one and six years of age. PNS was not related to general and skin illnesses. Conclusion: Summarizing, this study showed that late pregnancy anxiety and cortisol was associated with children's respiratory and digestive illnesses till the age of 3.0-3.5 years. Additionally, more daily hassles were related to more prescribed antibiotics between one and six years. These findings point in the direction of possible effects of PNS persisting beyond the first year of life and into toddlerhood, but disappearing at older ages. ARTICLE HISTORY

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Maternal prenatal stress is associated with the infant intestinal microbiota

Cited by 382 publications

References 50 publications

Sex differences in the gut microbiome–brain axis across the lifespan

Sex differences in the gut microbiome–brain axis across the lifespan

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Maternal late pregnancy anxiety and stress is associated with children’s health: a longitudinal study

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