Maternal quercetin administration during gestation and lactation decrease endoplasmic reticulum stress and related inflammation in the adult offspring of obese female rats

Abstract

Maternal QI in obese dams during gestation and lactation reduced birth weight and postnatal BW gain in the offspring, and helped to improve insulin sensitivity and lipid metabolism of the mature offspring via reducing ER stress and related inflammation in the liver and adipose tissue.

Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood

“…Different studies have shown that the administration of polyphenols to dams during prenatal and early postnatal periods can exert beneficial effects on body fat gain and different metabolic disorders, such us dyslipidaemia, insulin resistance and inflammation, on their offspring in later life [15][16][17]19]. However, in most of these studies, the metabolic programming effects of polyphenols have been observed after the administration of these compounds at high doses.…”

“…However, to the best of our knowledge, there is little data concerning the effects of polyphenol intake during pregnancy and lactation on maternal metabolism in studies that evaluate the metabolic programming effects of these bioactive compounds on the offspring. Related to this, Wu et al [19] recently demonstrated that the administration of quercetin during pregnancy and lactation at different doses improved the lipid profiles of the dams and that these beneficial effects were also observed in their offspring in adulthood, indicating that the effects of polyphenols on maternal metabolism affects early programming of the offspring.…”

“…For example, genistein was effective in preventing body weight gain of the offspring when administered during pregnancy and lactation [12,14] but also exerted harmful effects related to anxiety, aggressive behaviours, spatial learning and reproductive development [13,14]. In another study, male and female offspring of obese rats that received quercitin at different doses (50,100 and 200 mg kg −1 of body weight/day) during pregnancy and lactation had lower body weights, improved insulin sensitivity and lower grades of inflammation than their counterparts, although most of these effects were observed at the high doses [19]. Concerning the use of extracts rich in polyphenols, the administration of a grape skin extract rich in anthocyanins at 200 mg kg −1 of body weight/day to rats fed a high-fat diet (HFD) during lactation protected their male and female offspring against oxidative stress, hypertension, body fat gain, hypertriglyceridaemia and insulin resistance in adulthood [15,16].…”

“…We recently demonstrated that these bioactive food compounds can reach the foetuses and placentas of pregnant rats [11]. Furthermore, recent studies have shown that polyphenols can exert metabolic programming effects on the offspring through maternal intake [12][13][14][15][16][17][18][19][20]. For example, genistein was effective in preventing body weight gain of the offspring when administered during pregnancy and lactation [12,14] but also exerted harmful effects related to anxiety, aggressive behaviours, spatial learning and reproductive development [13,14].…”

Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

“…13 The NLRP3 inflammasome regulates the maturation and release of IL-1β and IL-18; and targeting of the NLRP3 inflammasome can exert neuroprotection in a rat model of SCI. 8 Quercetin, a kind of flavonoid found in variety of vegetables, beverages, fruits and herbs, exhibits anti-inflammatory 14 and antioxidant 15 properties. Therefore, it has been used for many diseases, such as focal cerebral ischemia 16 and intracerebral hemorrhage.…”