Maternal Recognition of Pregnancy in the Rabbit: Effect of Conceptus Removal1

Browning, Joan Y.; Wolf, Richard C.

doi:10.1095/biolreprod24.2.293

Cited by 27 publications

(11 citation statements)

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“…TCs were present in human non-pregnant and pregnant myometrium as a distinct cell type; c-kit (CD 117) and CD34 positive cells. TCs seem to have no excitable properties similar to smooth muscle cells [45].…”

Section: Discussionmentioning

confidence: 99%

Morphological, Histological and Immunohistochemical Study of the Rabbit Uterus during Pseudopregnancy

Abd-Elkareem¹

2017

J Cytol Histol

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Ten mature virgin rabbit does (4-5 months old) with mean weight of 2.4 kg were induced to ovulate; by intramuscular injection of HCG (50-70 IU). The day of induction was considered 0 days. Uteri were obtained from 14 h, 3, 7, 18 days post induction. At first stage of pseudopregnancy; the two uteri became hyperemic and slightly swollen. The uterine epithelium and endometrial glands epithelium were of columnar type with oval basal nuclei. The endometrial glands were few in number and small in size. The endometrial glands showed apocrine activity. The uterus had six longitudinal folds and the uterine epithelium form crypts. The endometrium had slight vascularization. At middle stage of pseudopregnancy, the two uteri became hyperemic and more swollen. This stage characterized by; mucosal folding, glandular formation, epithelial proliferation and thickening of the uterine wall. At last stage of pseudopregnancy; the two uteri became flaccid and more swollen. This stage characterized by dramatic changes in the uterine architecture in the form of: increased epithelial proliferation and crypt formation increase the complexity of luminal folding, increase in length, size and abundance of the uterine endometrial glands, increase in the uterine micro vascular development (increased abundance of the large microvessels and development of subepithelial capillary plexuses). Tunica vascularis could be demonstrated between the inner circular and outer longitudinal smooth muscle fibers of the myometrium at the all stages of psedopregnancy. Telocytes with its characteristic morphology could be demonstrated in the myometrium of the rabbit uterus during pseudopregnancy. Cell-specific immuno-localization of progesterone receptors alpha (PRA) in the rabbit uterus during pseudopregnancy revealed that, there were mild, moderate and strong nuclear PRA immunostaining in the endometrial epithelial cells, endometrial glands and in the smooth muscles fibers of the myometrium of the first, middle and last stages of pseudopregnancy respectively.The present study revealed that the morphological, histological and immunohistochemical changes in the rabbit uterus during pseudopregnancy resembled that occurred during early stage of pregnancy. These changes were characterized by dramatic changes in the uterine architecture in the form of: increased epithelial proliferation and crypt formation increase the complexity of luminal folding, increase in length, size and abundance of the uterine endometrial glands, increase in the uterine microvascular development. These uterine changes were accompanied with PRA immunolocalization in the uterine tissues.

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Section: Discussionmentioning

confidence: 99%

Morphological, Histological and Immunohistochemical Study of the Rabbit Uterus during Pseudopregnancy

Abd-Elkareem¹

2017

J Cytol Histol

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“…Romana Nowak, now one of my faculty colleagues, determined the day of maternal recognition of pregnancy in the rabbit. The day of maternal recognition of pregnancy is the day that either a signal is produced by the developing fetus or a uterine signal is blocked so that the corpus luteum continues to produce large amounts of P4 necessary for pregnancy (61)(62)(63). As in the majority of mammals, the first part of pregnancy is dependent upon P4 produced by the corpus luteum.…”

Section: Domestic Rabbit-zim Zam Thank You Ma'ammentioning

confidence: 99%

My Scientific Journey: From an Agrarian Start to an Academic Setting

Bahr

2017

Annu. Rev. Anim. Biosci.

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This article is a combination of an autobiography and a review of outstanding research done by over 70 graduate students, postdoctoral fellows, and visiting scientists along with excellent collaborators during my over-40-year career as a professor of reproductive physiology at the University of Illinois, UrbanaChampaign. I have also shared thoughts on mentoring, how research has changed over the years, and the future of reproductive physiology. I provide the reader with a snapshot of the challenges faced by a woman eager to obtain a PhD under the guidance of renowned professors in the early 1970s and to be hired as the first woman, and the only permanent female faculty member, for more than 20 years on a faculty of 40 men. As a comparative reproductive physiologist, I describe the various animal models used because they were the best models to answer specific questions in reproduction. Also, my graduate students and postdoctoral fellows were given the freedom to identify their research topics, articulate hypotheses to be tested, and select appropriate animal models. This approach caused students to take ownership of their research, resulting in the development of independent and creative scientists and over 170 publications, excluding chapters in top-tier journals. Finally, I am so grateful for a truly rich life mentoring graduate students and postdoctoral fellows who have become my lifelong friends.

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“…After ovulation, progesterone levels increase steadily in pseudopregnant and pregnant does until Day 12 when they begin to decline in pseudopregnant does, but remain fairly constant in pregnant does until several days before parturition (Browning & Wolf, 1981). The presence of the conceptus is necessary by Day 12 of gestation to rescue the CL of pregnancy and prevent luteal regression.…”

Section: Assaysmentioning

confidence: 99%

“…The rabbit placenta itself does not synthesize progesterone (Wilson & Siiteri, 1973;Holt & Ewing, 1974;Thau & Lanman, 1974). Browning & Wolf (1981) demonstrated that dependence on the conceptus develops between Days 10 and 18 of gestation. Lanman & Thau (1979) showed that treatment with oestrogen or anterior pituitary extracts prevents luteal regression following removal of the fetal placenta on Day 18 of pregnancy and concluded that the fetal placenta synthesizes a substance which is biologically similar to one of the anterior pituitary hormones or has a stimulatory effect on the pituitary.…”

Section: Introductionmentioning

confidence: 99%