Maternal Regulation of Trophoblast Proliferation by Decidual Interleukin-1 (IL-1)

Interleukin‐1 Modulation of Human Placental Trophoblast Proliferation

“…These cytokines could be categorized as immunodystrophism cytokines. IL-1, a mediator of inflammation at maternal-fetal interface, is produced mainly by decidua with a tissue level of 175 pg/mg total protein and secretory rate at 190 pg/ml/24 hours [ 15 ]. In the present study, this proinflammatory cytokine was investigated for its role in the inhibition of trophoblast prolilferation.…”

“…In a previous study using invasive extravillous trophoblast cell lines, maternal decidual IL-1 acted as a growth factor for these cells via the activation of PI3K and MAPK pathways [ 18 ]. This was a new evidence that placental growth is also, in part, controlled by the maternal cytokine [ 15 ].…”

“…IL-1 also regulates the production of other placental cytokines including M-CSF and IL-6 [ 13 , 14 ]. Furthurmore, it was recently demonstrated that maternal decidual IL-1 could stimulate proliferation of human first trimester extravillous trophoblast cell lines [ 15 ] by induction of other growth factors especially IL-6 and LIF [ 16 , 17 ]. Increased cell proliferation and survival in the extravillous trophoblast cell lines is mediated by the induction of the phosphatidylinositol-3 kinase (PI3K) and mitogen-activated protein kinase (MAPK) signal transduction pathways [ 18 ].…”