Maternal Renal and Interlobar Arteries Waveforms Evaluation with Color Doppler Ultrasound in Pregnancy-Induced Hypertension

Boemi, G; Bruno, Maria Teresa; Ferrera, Giuseppe La; Butera, Liborio; Puhirenti, Giuseppe; Lanzone, Antonio; Mancuso, Salvatore

doi:10.1159/000264292

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…Thus, these findings may explain one of the reasons for the conflicting results obtained by previous authors [5][6][7][8][9][10][11] who used the most common parameters of distal vascular resistance, such as systolic-diastolic ratio, resistance index, and pulsatility index, and suggest the need for the reliability test in each study.…”

Section: Discussionmentioning

confidence: 96%

“…The possible use of this tool as a replacement for angiography was initially assessed in renovascular disease 1,2 and renal transplantation 3,4 . In addition, several Doppler ultrasound studies [5][6][7] have been performed in healthy pregnant women and in women with pregnancy-induced hypertension (PIH) [8][9][10][11] , although to date, the differences in renal arterial and intrarenal arterial Doppler indices between normotensive and hypertensive pregnant women are ambiguous. However, authors [5][6][7][8][9][10][11] previously used only the most common parameters of distal vascular resistance, such as systolicdiastolic ratio, resistance index, and pulsatility index.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy‐induced hypertension

Nakai

Oya

Asakura

et al. 2002

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy‐induced hypertension

Nakai

Oya

Asakura

et al. 2002

Ultrasound in Obstet & Gyne

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“…The papillomavirus also seems capable of infecting and replicating in the cells of the syncytiotrophoblast, causing adverse events in pregnancy (abortion, gestosis, and preterm delivery) [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Oral HPV Infection in Women with HPV-Positive Cervix Is Closely Related to Oral Sex

et al. 2023

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The oral transmission of HPV and, consequently, the risk of oral cancer has increased in the last years. Oral sex has often been implicated among the risk factors for oral HPV infections, however, there is still no consensus on these topics, nor on the relationship between genital and oral HPV infections. The present study aimed to evaluate the coexistence of papilloma virus, at the levels of the oral and genital mucosa, in women with a histologically confirmed HPV lesions (and a positive HPV test) at the genital level and a negative HPV control group. We also evaluated how some risk factors, such as smoking, the number of partners, age, and sexual habits can influence the possible presence of the virus itself in the oropharynx of the same women. In total, 117 unvaccinated women aged between 18 and 52 were enrolled. We found that the prevalence of oral HPV infection was high among the women with concomitant genital HPV infection (22%) compared to the HPV-negative women (0%), and the estimated odds ratio was 17.36 (95% CI: 1.02, 297.04). In none of the women with oral HPV did we find any relevant clinical lesions. The potential risk factors for HPV infections in the oropharynx and genitals were analyzed based on questionnaire responses. A multivariate analysis showed that genital HPV infections were significantly associated with a number of sexual partners > 10 (OR 138.60, 95% CI: 6.04–3181.30, p < 0.001), but the data also referred to having between 3–5 or 6–10 partners as being significant, as were a high level of education (OR 6.24, 95% CI: 1.67–4.23.26 p = 0.003), a frequency of sexual intercourse >10 (OR 91.67 95% CI: 3.20–2623.52, p = 0.004), oral sex (OR 6.16, 95% CI: 1.22–31.19, p = 0.014), and >20 cigarettes/day (OR 6.09 95% CI: 1.21–30.61, p = 0.014). Furthermore, being “separate” and having multiple sexually transmitted diseases were also significantly associated with genital HPV infection. In contrast, oral HPV infections were significantly associated with women aged 36 to 50 years (OR 27.38, 95% CI: 4.37–171.37; p = 0.000202) and oral sex (OR 95.5, 95% CI: 5.13–1782.75, p = 0.001126).Additionally, being separate, being cohabitant, lifetime sexual partners of >10, 3–5 lifetime sexual partners, <20 years of age, >10 sexual intercourse per month, occasional and regular anal sex, >20 cigarettes per day, a history of sexually transmitted disease (herpes and multiple), and having a history of genital warts were significant. Screening and early diagnosis are considered to be practically unfeasible for this category of cancer, given the lack of visible lesions; the 9-valent HPV vaccine remains the only means that could help to successfully counter the growing incidence of oral squamous cell carcinoma.

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“…HPV 6 and 11 are related to recurrent respiratory papillomatosis in children, as well as approximately 90% of genital warts [ 8 ]. Studies conducted in recent decades have shown that it is capable of infecting and replicating in syncytiotrophoblast cells, causing adverse events in pregnancy (miscarriage, preeclampsia and preterm birth) [ 9 , 10 , 11 , 12 ]. In Italy the prevalence of HPV infection in women with a normal Pap test is 7.8%, while genotype 16 in women with cytological anomalies has a prevalence between 15.6% of the CIN1 lesion up to 61.2% of carcinoma invasive [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation of the HPV 16 Genotype Persistence in Women Undergoing LEEP for CIN3 with the Risk of CIN2+ Relapses in the First 18 Months of Follow-Up: A Multicenter Retrospective Study

Bruno,

Valenti,

Ruggeri

et al. 2024

Diagnostics

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Objective: Specific hr-HPV genotypes have different natural histories and different oncogenic capacity. This study aimed to investigate the risk of CIN2+ recurrence of the individual genotypes and evaluate how the duration of HPV persistence influences the risk of developing recurrent 16 cervical dysplasia of high grade (CIN2+). Methods: Data from patients with persistent HPV infection after primary conization were retrospectively extracted. Kaplan-Meier proportional hazards models were used to evaluate associations between the duration of HPV persistence and the risk of developing recurrent CIN2+. Kruskal-Wallis testing with Dunn’s multiple comparison test was used to test whether there was a statistically significant difference in the time to development of tumor recurrences between different genotypes. Results: Overall, 333 patients met the inclusion criteria. In 285 cases the HPV infection was persistent, in 48 cases (18%) it was transient, i.e., different genotypes after LEEP. Overall were diagnosed 39 relapses (13.7%), 79.5% (31/39 cases) were due to genotype 16, 20.5% (8/39) were linked to the other genotypes. Persistence of genotype 16 showed a 7-fold increased risk of developing a CIN2+ relapse, OR = 7.08 (95%CI: 3.12–16.08). Furthermore, the majority of relapses (38/39) occurred within 24 months of persistence with a cut-off represented by 18 months (p = 0.001) in which the relapse rate is maximum and the most frequently found genotype was the 16th with 31 (79.5%) cases of recurrence. Kruskal-Wallis test with Dunn’s multiple comparisons has shown statistically significant difference in the time of development of CIN2 relapses among HPV16 and other genotypes. (p < 0.05). Kaplan-meier analysis has shown statistically significant difference between the time to CIN2+ relapse onset in patients with HPV 16 infection and patients with other hrHPV genotypes. (p < 0.05) Conclusions: the study results suggest that persistent HPV infection after LEEP with the same HR genotype present before surgery represents one of the most important predictive factors of the risk of CIN2+ recurrence. The persistence of HPV16 for the first 18 months strongly correlates with the risk of developing a CIN2+ recurrence.

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Maternal Renal and Interlobar Arteries Waveforms Evaluation with Color Doppler Ultrasound in Pregnancy-Induced Hypertension

Cited by 10 publications

References 11 publications

Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy‐induced hypertension

Reproducibility of pulsed Doppler measurements of the maternal renal circulation in normal pregnancies and those with pregnancy‐induced hypertension

Oral HPV Infection in Women with HPV-Positive Cervix Is Closely Related to Oral Sex

Correlation of the HPV 16 Genotype Persistence in Women Undergoing LEEP for CIN3 with the Risk of CIN2+ Relapses in the First 18 Months of Follow-Up: A Multicenter Retrospective Study

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