Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

González-Andrade, Fabricio

doi:10.30554/archmed.19.2.3298.2019

Cited by 2 publications

(1 citation statement)

References 22 publications

(27 reference statements)

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“…Sampling: Blood samples to analyze hormone levels were taken from the peripheral veins at the same time as routine tests for sepsis, such as blood count, interleukin 6, Creactive protein, procalcitonin, and blood culture. Interleukin 6 state in sepsis was assessed previously [15]. Bias avoidance: information was always collected by the same person.…”

Section: Methodsmentioning

confidence: 99%

Non-thyroid Disease Syndrome and Other Thyroid Function Anomalies in Ecuadorian Newborns with Early and Late Neonatal Sepsis

Chimbo

Castro

González-Andrade

2019

SN Compr. Clin. Med.

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The aim of this study is to assess thyroid function in newborns with early and late neonatal sepsis by measuring T3, T4, and TSH. This study included 80 newborns with a diagnosis of neonatal sepsis divided into two groups: early neonatal sepsis and late neonatal sepsis, which during the clinical and laboratory manifestations of sepsis showed changes in thyroid hormones, particularly low T3 syndrome and low T3-T4. It excluded newborn children of mothers with thyroid disease and those with a history of perinatal asphyxia, congenital defects, and previous major surgeries. Development of the non-thyroid disease syndrome was confirmed in both study groups, with a prevalence of 54.2% for neonates with early neonatal sepsis and 80.95% for neonates with late neonatal sepsis. It also found low T3 in neonates with early neonatal sepsis and low T4 syndrome in neonates with late sepsis. Low levels of thyroid hormones are associated with a worse prognosis and a poor evolution in severely ill neonates. In Ecuadorian preterm infants with a mean gestational age of 32 weeks, the non-thyroid disease syndrome was found in 54.24% of the patients with early neonatal sepsis and in 80.95% with late neonatal sepsis. TSH levels are decreased in 11.86% of neonates with early neonatal sepsis and 10% in patients with late neonatal sepsis. All cases were children born of adolescent mothers with or without ruptured membranes, from urban areas of Quito.

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Section: Methodsmentioning

confidence: 99%

Non-thyroid Disease Syndrome and Other Thyroid Function Anomalies in Ecuadorian Newborns with Early and Late Neonatal Sepsis

Chimbo

Castro

González-Andrade

2019

SN Compr. Clin. Med.

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Investigating the Expression of miR 203a 3p and Its Role in Inflammatory Response in Severe Preeclampsia of Iraqi women Patients – A Comparative Study

Jaber,

Kadhim,

Al Kateeb

2024

Biomedical and Biotechnology Research Journal

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Background: Preeclampsia (PE) has long been a feared condition impacting women and their pregnancies. Researchers have recently discovered the role of miR203a-p3 in various diseases. The aim of the study was to explore the role of miR203a and measure its levels in pregnant patients, along with reviewing the advancement of inflammatory markers related to disease. Methods: Seventy serum samples and erythrocyte sedimentation rate (ESR) tubes were collected from pregnant women aged 25–33 who were diagnosed with serious PE. Upon this, 15 samples were chosen for testing of the deemed levels and gene expression of miR203a. Laboratory evaluation was mainstreamed in the study, including measurements of serum creatinine, blood urea, and uric acid. These parameters were quantitated using turbidity techniques and coulometric methods for C-reactive protein. In addition, we appraised the ESR uptake by the time method and examined fibrinogen by the agglutination time method. We quantified interleukin-6 (IL-6) using an enzyme-linked immunosorbent assay. Results: The serum levels of biomarkers and inflammatory tests differed significantly in the patients compared to controls. Similarly, a rise in gene expression resulted in an abatement in the level of miR203-p3, and there was a positive direct correlation between them. Conclusion: Patients exhibit high levels of biomarkers and IL-6, along with reduced concentration and expression of miR203a. There is a significant positive correlation between miR203a and disease. Finally, miR203 has played an active role in the current disease.

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Maternal risk factors in full-term newborns with early onset sepsis related with Interleukin-6 in umbilical blood

Cited by 2 publications

References 22 publications

Non-thyroid Disease Syndrome and Other Thyroid Function Anomalies in Ecuadorian Newborns with Early and Late Neonatal Sepsis

Non-thyroid Disease Syndrome and Other Thyroid Function Anomalies in Ecuadorian Newborns with Early and Late Neonatal Sepsis

Investigating the Expression of miR 203a 3p and Its Role in Inflammatory Response in Severe Preeclampsia of Iraqi women Patients – A Comparative Study

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