Maternal salivary testosterone in pregnancy and fetal neuromaturation

Voegtline, Kristin; Costigan, Kathleen A.; DiPietro, Janet A.

doi:10.1002/dev.21550

Cited by 5 publications

(2 citation statements)

References 60 publications

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“…По данным авторов, выполнявших измерения тестостерона в слюне, уровни гормона повышаются к концу гестации, после 36 нед. беременности [17]. В нашем исследовании заключительное измерение уровней тестостерона проводилось до 32 нед.…”

Section: Discussionunclassified

The interplay of hormonal and infectious factors in the pathogenesis of complicated pregnancy

2022

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Introduction. The causes for adverse pregnancy outcomes are usually complex and, in some cases, can worsen each other.Aim. To assess the role and establish the interplay of hormonal and infectious factors in the pathological course of pregnancy in women with threatened spontaneous miscarriage.Materials and methods. A total 120 pregnant women were enrolled for the observational prospective study, in which they were divided into 4 groups. Group 1 included 32 patients with threatened spontaneous miscarriage and hyperandrogenism (HA), who received glucocorticosteroids (GCS); group 2 included 28 patients with threatened spontaneous miscarriage and HA, who did not receive GCS; group 3 included 30 patients with threatened spontaneous miscarriage without HA; group 4 (control) included 30 women with a physiological course of pregnancy. The following examination methods were used: clinical assessment of the course of pregnancy; measurement of the serum levels of dehydroepiandrosterone sulfate (DHEA-S), 17-hydroxyprogesterone (17-OHP) and total testosterone at weeks 5 to 8, 9 to 12, 13 to 18, 19 to 24 and 25 to 32 of gestation; microbiological tests of vaginal discharge.Results. The evaluation of androgenic status showed that the levels of the tested hormonal parameters in women with HA significantly exceeded those of the control group, while the changes in 17-OHP and testosterone secretion was comparable to that in women without HA, and DHEA-S level decreased to control values by the third trimester. The use of corticosteroids was associated with significant changes in the values and secretion levels of 17-OHP and DHEA-S, but not testosterone; DHEA-S levels decreased to the values that were significantly lower as compared to all groups in the third trimester of pregnancy.Conclusions. Vaginal infections play an important role in the genesis of gestational failures. Hyperandrogenism exacerbates the problem of miscarriage, however, the use of corticosteroids does not result in improved hormonal characteristics and clinical pregnancy outcomes, deteriorating the vaginal biocenosis.

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Section: Discussionunclassified

The interplay of hormonal and infectious factors in the pathogenesis of complicated pregnancy

2022

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“…Testosterone plays an important role in fetal development [ 1 ], sperm production [ 2 ], and the development of male sexual characteristics. However, testosterone production is known to decrease with aging and obesity [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Cysteine Sulfoxides Enhance Steroid Hormone Production via Activation of the Protein Kinase A Pathway in Testis-Derived I-10 Tumor Cells

Nakayama

Yamagishi

et al. 2020

Molecules

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Testosterone plays an important role in male sexual characteristics and maturation, and decreased testosterone levels increase the risk of several diseases. Recently, onion extract rich in cysteine sulfoxides, which are amino acids unique to onions, has been reported to alleviate age-related symptoms resulting from decreased testosterone levels in males. However, the mechanism underlying the suppression of low testosterone levels by cysteine sulfoxides has not been elucidated. In this study, we found that onion extract containing cysteine sulfoxides enhanced progesterone, a precursor of testosterone, in mouse testis-derived I-10 tumor cells. Furthermore, cysteine sulfoxides activated protein kinase A (PKA) and cyclic adenosine monophosphate response element-binding protein, which are key factors in steroidogenesis. These results suggest that cysteine sulfoxides enhance steroid hormone production via activation of the PKA signaling pathway.

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Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study

Zheng

Sun

Xian

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background Evidence showed maternal androgen levels in both healthy/general population and populations with hyperandrogenic disorders were inversely associated with offspring’s birth weight. We aimed to investigate the causal effect of maternal testosterone levels in general population on offspring’s birth weight and preterm delivery risk using two-sample Mendelian randomization (MR) method. Methods We obtained independent genetic instruments from a sex-specific genome wide association study with up to 230,454 females of European descent from UK biobank. Genetic instruments with consistent testosterone effects but no aggregate effect on sex-hormone binding globulin were used to perform the main analysis. Summary-level data of offspring’s birth weight with offspring's genotype adjusted was obtained from a study with 210,406 females of European descent. Summary-level data of preterm delivery was obtained from the FinnGen study (6,736 cases and 116,219 controls). Results MR analysis showed per standard deviation (0.62 nmol/L) increase in testosterone levels could reduce offspring's birth weight by 37.26 g (95% confidence interval = 19.59 g to 54.94 g, p = 3.62×10 -5). Per standard deviation increase in testosterone levels was also associated with an increased risk of preterm delivery (odds ratio = 1.329, 95% confidence interval = 1.161 to 1.520, p = 3.57×10 -5). Similar results were found in different MR methods and multivariable MR analyses. Conclusion This two-sample MR study showed genetically determined higher circulating testosterone levels in females from the general population were associated with low birth weight of offspring and increased risk of preterm delivery.

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Maternal salivary testosterone in pregnancy and fetal neuromaturation

Cited by 5 publications

References 60 publications

The interplay of hormonal and infectious factors in the pathogenesis of complicated pregnancy

The interplay of hormonal and infectious factors in the pathogenesis of complicated pregnancy

Cysteine Sulfoxides Enhance Steroid Hormone Production via Activation of the Protein Kinase A Pathway in Testis-Derived I-10 Tumor Cells

Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study

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