2020
DOI: 10.1093/jpids/piaa133
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Maternal SARS-CoV-2 Infection Associated to Systemic Inflammatory Response and Pericardial Effusion in the Newborn: A Case Report

Abstract: Vertical transmission of SARS-CoV-2 has already been described, while clinical consequences to the fetus are still under investigation. This article reports a case of systemic fetal inflammatory response and pericardial effusion. As far as is known, this is the first case of fetal/neonatal cardiac complications related to SARS-CoV-2 infection.

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Cited by 25 publications
(27 citation statements)
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“…Fever was a striking feature in term neonates leading to suspicion of possible MIS-N, but skin manifestations and gastrointestinal symptoms were not common, as against frequent reports in older children [23,24]. Preterm neonates tended to have severe symptoms presenting with respiratory distress, and cardiac dysfunction, similar to the observation of Lima et al [9]. .…”
Section: Discussionsupporting
confidence: 63%
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“…Fever was a striking feature in term neonates leading to suspicion of possible MIS-N, but skin manifestations and gastrointestinal symptoms were not common, as against frequent reports in older children [23,24]. Preterm neonates tended to have severe symptoms presenting with respiratory distress, and cardiac dysfunction, similar to the observation of Lima et al [9]. .…”
Section: Discussionsupporting
confidence: 63%
“…MIS-C in the paediatric population is now better described; however, the spectrum of possible manifestations in neonates presenting with MIS-N has only been reported in a small number of cases [5,9,10,11]. An increasing number of pregnant mothers are either exposed to SARS-CoV-2 during pregnancy or received a vaccination or may receive antibodies via blood product transfusion.…”
Section: What Is Newmentioning
confidence: 99%
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“…In these previous published cases, neonates have been reported to have severe multiple organ dysfunction, including respiratory distress, acute myocardial injury with or without coronary artery dilatation, abnormal renal and liver function, skin lesions, and elevated inflammatory markers. [5][6][7][8][9][10][11][12] Here, we report a case of neonatal MIS-C found to have an atypical diffuse thickening in coronary artery walls, whose diagnosis required a multi-imaging approach.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…This condition has been reported anecdotally in the newborn population, presenting with fever and multi-site inflammation, especially myocarditis manifesting clinically or with raised biomarkers such as Troponin and ProB-type natriuretic peptide(proBNP) [9]. MIS-C in the paediatric population is now better described; however, the spectrum of possible manifestations in neonates presenting with MIS-N has only been reported in a small number of cases [5,[10][11][12][13][14][15][16]. Authors of this case series (KM and PK) were involved in formally collecting data for the national Indian registry of SARS-CoV2 in newborns, up to August 2020 which was presented at national neonatal conferences and subsequently published [17].…”
Section: Introductionmentioning
confidence: 99%