Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

Abstract

Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.

Gestation and breastfeeding in schistosomotic mice differentially alters the expression of histone deacetylases (HDACs) in adult offspring

“…Maternal infection by S. mansoni can alter the degree of immune competence of the offspring in the long term, either through in-utero contact or breastfeeding. (2,3,4,5) In this study, the effects of gestation and breastfeeding were evaluated separately in S. mansoni-infected mothers. Therefore, the expression of HDACs, and cytokine production by lymphocytes and macrophages was assessed.…”

“…In studies using immunisation with ovalbumin as adjuvant, gestation in infected mothers was correlated with increased production of IL-10. (2,5) Furthermore, Li et al (19) reported the positive regulation of HDAC9 in immature peritoneal macrophages through the action of acetyltransferase Dnmt3, leading to increased production of IFN-α and IFN-β via deacetylation of kinase TBK1. Mice deficient for Dnmt3a showed greater susceptibility to infection by vesicular stomatitis virus (VSV).…”

“…It is known that the immunological status of schistosomotic mothers can induce long-term alterations in the immune response of the offspring. (2,3,4,5) An experimental study on the effects of gestation and breastfeeding in infected mothers, separately, showed that gestation in these mothers led to potential immunosuppression in adult offspring, with elevated production of IL-10 and lower levels of anti-ovalbumin (OA) antibodies. (2) In addition, offspring born to infected mothers had a lower frequency of B lymphocytes, and the capacity for antigen presentation by CD11c+ cells was partially impaired.…”