Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study

Hibbeln, Joseph R.; Davis, John M.; Steer, Colin; Emmett, Pauline M; Rogers, Imogen; Williams, Cathy; Golding, Jean

doi:10.1016/s0140-6736(07)60277-3

Cited by 860 publications

(532 citation statements)

References 31 publications

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“…This could be because carbohydrates serve as an energy source for both the mother and developing fetus, with the need for iron and proteins being justified by the need to maintain hemoglobin content as well as building the body for the fetus. Fruits serve as sources of vitamins that are of great importance to the pregnant mothers and foetus with fish supplying the growing fetus and the pregnant woman with essential fatty acids like omega-3 [23] although Hibbein et al [24] and Oken et al [25] discourage consumption of the big types of fish like sharks repeatedly since they lead to poor development of the fetus' nervous system [24] [25]. The findings of the study indicate that there is no correlation between morning sickness and cravings.…”

Section: Cravings and Morning Sicknessmentioning

confidence: 81%

Alteration of Human Chorionic Gonadotropin Levels among Pregnant Women with Morning Sickness Attending Antenatal Care Services at Ishaka Adventist Hospital, Uganda

Kasande¹,

Eze²,

Ezekiel³

et al. 2017

JBM

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Globally, 50% -90% of pregnant women are affected by morning sickness of pregnancy, especially during the first trimester. Therefore this study was carried out to establish if there is association between urinary hCG levels and severity of nausea, retching and vomiting among pregnant women attending antenatal care (ANC) services at Ishaka Adventist Hospital (IAH). It was a quantitative cross-sectional study in which a pre-tested and standardized questionnaire with a mixture of both open and closed ended questions was used to collect data from respondents to determine the clinical history, socio-demographic characteristics, and clinical features of morning sickness and/or hyperemesis gravidarum. Urine samples were also collected from each participant and analyzed using the Beckman Coulter Access 2 immunoassay system and Access Total hCG reagent pack at Mbarara University of Science and Technology. The findings showed that 63% of the respondents experienced morning sickness with the majority having a mild form. There was also no significant relationship between hCG levels and severity of morning sickness and no correlation between physiological characteristics (gravidity, age and weight) (correlation coefficient −0.05186, −0.0469 and 0.157 respectively). In addition, there was no correlation between cravings, aversions and morning sickness (correlation coefficient −0.0262 and 0.227 respectively). In conclusion, the study revealed that there was a high prevalence of morning sickness of pregnancy although, it was mild; no association between severity of morning sickness and levels of hCG as well as correlation between cravings and aversions with hCG levels in the study population. Considering the limi- tations of this study, it is recommended that studies should be undertaken for the quantitative determination of total hCG levels in urine for all pregnant women with morning sickness to be able to draw a definitive conclusion.

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Section: Cravings and Morning Sicknessmentioning

confidence: 81%

Alteration of Human Chorionic Gonadotropin Levels among Pregnant Women with Morning Sickness Attending Antenatal Care Services at Ishaka Adventist Hospital, Uganda

Kasande¹,

Eze²,

Ezekiel³

et al. 2017

JBM

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confidence: 99%

“…1 1 Northern Ireland Centre for Food & Health (NICHE), University of Ulster, Coleraine, BT52 1SA, 2 University of Rochester, School of Medicine and Dentistry, United States, 3 Ministry of Health, Seychelles…”

mentioning

confidence: 99%

Maternal long chain polyunsaturated fatty acid status is associated with child growth

et al. 2013

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Consumption of fish during pregnancy is known to be beneficial for child neurodevelopment and cognitive function (1) . Fish is the major dietary source of the long chain polyunsaturated fatty acids (LCPUFA), particularly the n-3 LCPUFA, docosahexaenoic acid (DHA). DHA is essential for brain growth and function and the human body can synthesise only small amounts. We have recently shown that higher maternal n-3 LCPUFA status during pregnancy is associated with improved language scores in children at 5 years of age (2) . Other studies have suggested that LCPUFA status has an impact on infant growth (3) , a factor which is also known to influence neurodevelopment. The aim of this study was to investigate associations between maternal LCPUFA status and child growth outcomes in a population of high fish consumers.This study was conducted as part of the Seychelles Child Development and Nutrition Study Cohort 2. Blood samples were taken from pregnant women at 28 weeks gestation (n = 1474) and serum fatty acid methyl esters were quantified using GC-MS, following lipid extraction, as previously described (4) . LCPUFA measured included linoleic acid (LA), arachidonic acid (AA), alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and DHA. In the offspring, various measures of child growth, including gestational age and birth weight were assessed at birth. At 20 months of age, measures of height, weight and head circumference were obtained for the child. Multiple linear regression analyses, controlling for gestational age, were used to test associations between maternal LCPUFA status and child growth outcomes at birth and at 20 months of age.The mean (SD) age of pregnant women at enrolment to the study was 26 (6) years. Spearman correlation analyses showed that gestational age of the child was significantly correlated with child birth weight (r = 0.454, P < 0.0001) and child height (r = 0.066, P = 0.021), weight (r = 0.089, P = 0.002) and head circumference (r = 0.064, P = 0.024) at 20 months of age.Maternal AA concentrations significantly predicted height of the child at 20 months (b = 0.115, P < 0.0001). Maternal LA and total n-6 concentrations significantly predicted weight of the child at birth. Maternal LA, DHA, total n-3 and total n-6 concentrations significantly predicted child height and weight at 20 months of age. Maternal LCPUFA status did not significantly predict child head circumference at 20 months of age. These data concur with recent literature (5) and add to the body of evidence demonstrating associations between maternal LCPUFA status during pregnancy and child growth outcomes. Such associations warrant further investigation.

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“…Recently meta-analyses of randomized controlled intervention trials were published reviewing effects of n-3 LC-PUFA supplementation of women with low risk and high risk pregnancies, respectively, on pregnancy outcomes [21,22] The results show that n-3 LC-PUFA supplementation during pregnancy in general only to a small extent enhances pregnancy duration, but the risk of early preterm delivery is significantly reduced in high risk pregnancies (relative risk 0.39, 95% CI 0·18, 0·84). While a large number of studies have evaluated the influence of n-3 LC-PUFA supplementation on gestational length and birth weight, only few randomized studies have examined the effects of perinatal dietary LC-PUFA on neurodevelopment, but very recently in a large cohort study it could be shown that, low maternal seafood (the predominant source of n-3 LC-PUFA) intake during pregnancy was associated with increased risk of their children at age 8 years to be in the lowest quartile for the verbal intelligence quotient, suboptimum outcomes for prosocial behaviour, fine motor, communication, and social development scores [23].…”

Section: Lc-pufa Supply and Outcomesmentioning

confidence: 99%

Perinatal long chain polyunsaturated fatty acid supply Are there long term consequences?

Demmelmair

Larqué

Koletzko

2007

OCL

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Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study

Cited by 860 publications

References 31 publications

Alteration of Human Chorionic Gonadotropin Levels among Pregnant Women with Morning Sickness Attending Antenatal Care Services at Ishaka Adventist Hospital, Uganda

Alteration of Human Chorionic Gonadotropin Levels among Pregnant Women with Morning Sickness Attending Antenatal Care Services at Ishaka Adventist Hospital, Uganda

Maternal long chain polyunsaturated fatty acid status is associated with child growth

Perinatal long chain polyunsaturated fatty acid supply Are there long term consequences?

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