Maternal separation is associated with DNA methylation and behavioural changes in adult rats

Anier, Kaili; Malinovskaja, Kristina; Pruus, K.; Aonurm-Helm, Anu; Zharkovsky, Alexander; Kalda, Anti

doi:10.1016/j.euroneuro.2013.07.012

Cited by 71 publications

(51 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This association was specific to morphine administration and reversed by L-dopa treatment. Also in the nucleus accumbens, repeated SAM pretreatment was found to modify cocaineinduced methylation changes in the neuropeptides Cck and Gal, as well as the glutamate transporter Slc17a7 [34]. Pol Bodetto et al [35] reported that methylation of Pp2cβ, a gene involved in cellular function, was higher in the brain of cocaine-exposed rats versus controls.…”

Section: Adulthoodmentioning

confidence: 99%

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

2015

View full text Add to dashboard Cite

Growing evidence points to the role of epigenetic mechanisms, including DNA methylation, in substance use and addiction. We conducted a systematic review of 47 recent (2012)(2013)(2014)(2015) animal and human studies that investigate DNA methylation and substance use/exposure, spanning preconception to adulthood. The majority of extant studies (i) focused on exposure during adulthood, (ii) examined the effects of alcohol use, (iii) employed a candidate gene approach, and (iv) were cross-sectional. While studies generally support an association between substance use/exposure and DNA methylation and also suggest that developmental context and timing matter, a dearth of longitudinal data and low comparability across studies currently limits the conclusions that can be drawn. Future challenges and directions for the field are discussed.

show abstract

Section: Adulthoodmentioning

confidence: 99%

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

2015

View full text Add to dashboard Cite

show abstract

“…Maternal stress was recently shown to paradoxically increase Dnmt1 , Dnmt3a, and Dnmt3b mRNA levels and decrease global DNA methylation levels in the adult NAc, although methylation was increased at promoters of genes potentially relevant to stress or drug behavior including protein phosphatase 1 catalytic subunit ( Pp1c ) and adenosine A2A receptor ( A 2a r ) 188 . Maternal separation-induced DNA methylation changes in NAc may underlie enhanced locomotor responses to acute cocaine treatment in adulthood 188 . Further studies are needed to understand the role of epigenetics in the cross-sensitization of early life stress and drug sensitivity.…”

Section: Epigenetics and Addictionmentioning

confidence: 99%

Epigenetic Signaling in Psychiatric Disorders

Peña

Bagot

Labonté

et al. 2014

Journal of Molecular Biology

134

145

View full text Add to dashboard Cite

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function. While genetic factors are important in the etiology of disorders such as depression and addiction, relatively high rates of discordance among identical twins clearly indicate the importance of additional mechanisms. Environmental factors such as stress or prior drug exposure are known to play a role in the onset of these illnesses. Such exposure to environmental insults induces stable changes in gene expression, neural circuit function, and ultimately behavior, and these maladaptations appear distinct between developmental and adult exposures. Increasing evidence indicates that these sustained abnormalities are maintained by epigenetic modifications in specific brain regions. Indeed, transcriptional dysregulation and associated aberrant epigenetic regulation is a unifying theme in psychiatric disorders. Aspects of depression and addiction can be modeled in animals by inducing disease-like states through environmental manipulations (e.g., chronic-stress, drug administration). Understanding how environmental factors recruit the epigenetic machinery in animal models is revealing new insight into disease mechanisms in humans.

show abstract

“…Other labs have also demonstrated a relationship between ELS and HDAC expression (Tesone-Coelho et al, 2013). Additionally, ELS decreased nucleus accumbens DNMT expression rates, which were associated with hyper-methylation of neuronal plasticity genes (Anier et al, 2013). It is thus apparent that ELS modulates the epigenome by numerous mechanisms.…”

Section: Els and Epigenetic Effectsmentioning

confidence: 99%

“…There is thus an interesting and circular relationship, in which the epigenome prior to drug use may predispose the individual to higher addiction vulnerability or resiliency, and the epigenetic response to drugs of abuse further modulates risk and progression towards addiction. Interestingly, despite the established link between ELS and addictive disorders, investigation of ELS-induced epigenetic alterations that predispose an individual to a high risk for addiction is still very much in its infancy (Anier et al, 2013; Lewis et al, 2013; Romano-López et al, 2012; Tesone-Coelho et al, 2013). …”

Section: Drugs Of Abusementioning

confidence: 99%

Early-life stress interactions with the epigenome

Lewis

2014

Behavioural Pharmacology

View full text Add to dashboard Cite

Throughout the 20th century a body of literature concerning the long lasting effects of early environment was produced. Adverse experiences in early life, or early life stress (ELS), is associated with a higher risk for developing various psychiatric illnesses. The mechanisms driving the complex interplay between ELS and adult phenotype has baffled many investigators for decades. Over the last decade, the new field of neuroepigenetics has emerged as one possible mechanism by which ELS can have far reaching effects on adult phenotype, behavior, and risk for psychiatric illness. Here we review two commonly investigated epigenetic mechanisms, histone modifications and DNA methylation, and the emerging field of neuroepigenetics as they relate to ELS. We discuss the current animal literature demonstrating ELS induced epigenetic modulation of gene expression that results in altered adult phenotypes. We also briefly discuss other areas in which neuroepigenetics has emerged as a potential mechanism underlying environmental and genetic interactions.

show abstract

Maternal separation is associated with DNA methylation and behavioural changes in adult rats

Cited by 71 publications

References 46 publications

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

DNA Methylation, Substance Use and Addiction: a Systematic Review of Recent Animal and Human Research from a Developmental Perspective

Epigenetic Signaling in Psychiatric Disorders

Early-life stress interactions with the epigenome

Contact Info

Product

Resources

About