Maternal separation prior to neonatal hypoxia‐ischemia: Impact on emotional aspects of behavior and markers of synaptic plasticity in hippocampus

Markostamou, Ioanna; Ioannidis, Anestis; Dandi, Evangelia; Mandyla, Maria-Aikaterini; Nousiopoulou, Evangelia; Simeonidou, Constantina; Spandou, Evangelia; Tata, Despina Α.

doi:10.1016/j.ijdevneu.2016.04.002

Cited by 18 publications

(24 citation statements)

References 136 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study re-examines FEs in individuals with ASD after accounting for impaired interoception (perception of the state of one’s own body). This is necessary due to recent claims of atypical interoception in ASD [ 8 – 12 ] and of a role for interoception in decision-making [ 13 , 14 ]. It was previously found that autistic 1 individuals are less susceptible to FEs because they do not incorporate emotional information into decision-making.…”

mentioning

confidence: 99%

Emotional decision-making in autism spectrum disorder: the roles of interoception and alexithymia

2016

View full text Add to dashboard Cite

The way choices are framed influences decision-making. These “framing effects” emerge through the integration of emotional responses into decision-making under uncertainty. It was previously reported that susceptibility to the framing effect was reduced in individuals with autism spectrum disorder (ASD) due to a reduced tendency to incorporate emotional information into the decision-making process. However, recent research indicates that, where observed, emotional processing impairments in ASD may be due to co-occurring alexithymia. Alexithymia is thought to arise due to impaired interoception (the ability to perceive the internal state of one’s body), raising the possibility that emotional signals are not perceived and thus not integrated into decision-making in those with alexithymia and that therefore reduced framing effects in ASD are a product of co-occurring alexithymia rather than ASD per se. Accordingly, the present study compared framing effects in autistic individuals with neurotypical controls matched for alexithymia. Results showed a marked deviation between groups. The framing effect was, in line with previous data, significantly smaller in autistic individuals, and there was no relationship between alexithymia or interoception and decision-making in the ASD group. In the neurotypical group, however, the size of the framing effect was associated with alexithymia and interoception, even after controlling for autistic traits. These results demonstrate that although framing effects are associated with interoception and alexithymia in the neurotypical population, emotional and interoceptive signals have less impact upon the decision-making process in ASD.

show abstract

mentioning

confidence: 99%

Emotional decision-making in autism spectrum disorder: the roles of interoception and alexithymia

2016

View full text Add to dashboard Cite

show abstract

“…As demonstrated in Table 2 , although all questionnaires focus on the core construct of sensory processing, they did not all conceptualize this the same way. Therefore, in order to thoroughly assess an adult with ASD, it may be necessary and preferable to triangulate the results from multiple questionnaires, or to use different questionnaires depending on the purpose of the assessment [ 3 , 4 , 6 , 16 ]. For instance, some self-report measures (e.g., the SPQ) focus on assessing basic sensory perception.…”

Section: Discussionmentioning

confidence: 99%

“…In the future, however, brain imaging may be utilized in combination with other assessment methods, to hone in on specific brain networks or structures to target to influence functioning. The clinical applicability of neuroimaging is likely to alter in the near future, as interventions that target neural or physiological processes such as repetitive transcranial magnetic stimulation, deep brain stimulation, medication/hormone therapy, desensitization therapy, and biofeedback applications become more commonly integrated with clinical practice [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite completing an exhaustive review of the literature, only 17% of the studies included individuals with IDD in their sample. As described by DuBois et al, (2016) [ 16 ], advances in communication technology have demonstrated that many individuals with ASD who have communication difficulties may be able to provide feedback about physiological processes, if adapted to meet their communication and sensory needs. Incorporating the use of communication aids and adapted communication strategies such as pictures and visual scales should be included in future research.…”

Section: Discussionmentioning

confidence: 99%

“…Thirdly, as a self-report questionnaire, the AASP is not designed to be completed by caregivers in situations where an adult with ASD cannot complete the assessment independently. Finally, the AASP does not include questions on interoception, or internal sensory processing, which has been repeatedly demonstrated to be compromised in individuals with ASD and may have significant behavioral implications (e.g., self-injurious behavior, experience of gastrointestinal functions or pain) [ 16 ]. Therefore, clinicians need information on other assessment measures or techniques that they could potentially use either alone or in combination with questionnaires like the AASP to address some of the limits of this questionnaire.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessing Sensory Processing Dysfunction in Adults and Adolescents with Autism Spectrum Disorder: A Scoping Review

et al. 2017

View full text Add to dashboard Cite

Sensory reactivity is a diagnostic criterion for Autism Spectrum Disorder (ASD), and has been associated with poorer functional outcomes, behavioral difficulties, and autism severity across the lifespan. Yet, there is little consensus on best practice approaches to assessing sensory processing dysfunction in adolescents and adults with ASD. Despite growing evidence that sensory symptoms persist into adolescence and adulthood, there is a lack of norms for older age groups, and pediatric assessments may not target appropriate functional outcomes or environments. This review identified approaches used to measure sensory processing in the scientific literature, and to describe and compare these approaches to current best practice guidelines that can be incorporated into evidence-based practice. Method and Analysis: A search of scientific databases and grey literature (professional association and ASD society websites), from January 1987–May 2017, uncovered 4769 articles and 12 clinical guidelines. Study and sample characteristics were extracted, charted, and categorized according to assessment approach. Results: There were 66 articles included after article screening. Five categories of assessment approaches were identified: Self- and Proxy-Report Questionnaires, Psychophysical Assessment, Direct Behavioral Observation, Qualitative Interview Techniques, and Neuroimaging/EEG. Sensory research to date has focused on individuals with high-functioning ASD, most commonly through the use of self-report questionnaires. The Adolescent and Adult Sensory Profile (AASP) is the most widely used assessment measure (n = 22), however, a number of other assessment approaches may demonstrate strengths specific to the ASD population. Multi-method approaches to assessment (e.g., combining psychophysical or observation with questionnaires) may have clinical applicability to interdisciplinary clinical teams serving adolescents and adults with ASD. Contribution: A comprehensive knowledge of approaches is critical in the clinical assessment of a population characterized by symptomatic heterogeneity and wide-ranging cognitive profiles. This review should inform future development of international interdisciplinary clinical guidelines on sensory processing assessment in ASD across the lifespan.

show abstract

Expression of synaptophysin and BDNF in the medial prefrontal cortex following early life stress and neonatal hypoxia‐ischemia

Tata

Dandi

Spandou

2020

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

This study aims at investigating whether early stress interacts with brain injury due to neonatal hypoxia‐ischemia (HI). To this end, we examined possible changes in synaptophysin (SYN) and brain‐derived neurotrophic factor (BDNF) expression in the medial prefrontal cortex (mPFC) of maternally separated rats that were subsequently exposed to a HI episode. Rat pups (n = 11) were maternally separated during postnatal days 1 to 6 (3hr/day), while another group was left undisturbed (n = 11). On postnatal day 7, a subgroup (n = 12) from each postnatal manipulation was exposed to HI. Synaptophysin and BDNF expression was estimated in mPFC prelimbic and anterior cingulate subregions of the ipsilateral and contralateral to the occluded common carotid artery hemispheres. Maternally separated rats expressed significantly less BDNF and SYN in both hemispheres. Neonatal HI significantly reduced BDNF and SYN expression in the ipsilateral mPFC only and this reduction was not further altered by early stress. Our findings indicate the enduring negative effect of a short period of maternal separation on the expression of mPFC SYN and BDNF. They, also, reveal that the HI‐associated decreases in these markers are limited to the ipsilateral mPFC and are not exacerbated by early stress. These decreases may have important functional implications given the role of prefrontal area in high‐order cognition.

show abstract

Maternal separation prior to neonatal hypoxia‐ischemia: Impact on emotional aspects of behavior and markers of synaptic plasticity in hippocampus

Cited by 18 publications

References 136 publications

Emotional decision-making in autism spectrum disorder: the roles of interoception and alexithymia

Emotional decision-making in autism spectrum disorder: the roles of interoception and alexithymia

Assessing Sensory Processing Dysfunction in Adults and Adolescents with Autism Spectrum Disorder: A Scoping Review

Expression of synaptophysin and BDNF in the medial prefrontal cortex following early life stress and neonatal hypoxia‐ischemia

Contact Info

Product

Resources

About