Maternal serum and fetal cord-blood ischemia-modified albumin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis

Varikasuvu, Seshadri Reddy; Duggina, Pragathi; Vedhantam, Mrudula; Munikumar, Manne; Varma, Neelakant; Nagaram, Srinivas

doi:10.1080/14767058.2017.1368480

Cited by 17 publications

(11 citation statements)

References 40 publications

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“…A meta-analysis of publications available in NCBI PubMed and other databases conducted by Reddy et al [153] showed that IMA is a potentially useful biomarker for PE with reasonable accuracy (AUC = 0:860). The authors concluded that the evaluation of maternal serum IMA and fetal cord-blood IMA concentrations is useful as a simple, novel, and inexpensive marker of oxidative stress status in PE patients [154].…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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Albumin is one of the most abundant proteins in the body of mammals: about 40% of its pool is located in the intravascular space and the remainder is found in the interstitial space. The content of this multifunctional protein in blood is about 60-65% of total plasma proteins. A decrease in its synthesis or changes of functional activity can destabilize oncotic blood pressure, cause a violation of transporting hormones, fatty acids, metals, and drugs. Albumin properties change under ischemic attacks associated with oxidative stress, production of reactive oxygen species, and acidosis. Under these conditions, ischemia-modified albumin (IMA) is generated that has a reduced metal-binding capacity, especially for transition metals, such as copper, nickel, and cobalt. The method of determining the cobalt-binding capability of HSA was initially proposed to evaluate IMA level and then licensed as an ACB test for routine clinical analysis for myocardial ischemia. Subsequent studies have shown the viability of the ACB test in diagnosing other diseases associated with the development of oxidative stress. This review examines recent data on IMA generation mechanisms, describes principles, advantages, and limitations of methods for evaluation of IMA levels, and provides detailed analysis of its use in diagnostic and monitoring therapeutic efficacy in different diseases.

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Section: Obstetrics and Gynecologymentioning

confidence: 99%

Ischemia-Modified Albumin: Origins and Clinical Implications

et al. 2021

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“…Ischemia Modifi ed Albumin has been found to be very useful marker for the detection of acute myocardial ischemia but now it is being used to investigate the relation of many diseases to hypoxia/ ischemia such as preeclampsia, appendicitis, hepatitis B-related chronic liver diseases, intestinal ischemia necrotizing enterocolitis. 22,[24][25][26][27][28] Similarly, we used IMA to demonstrate hypoxia/ischemia in the etiopathogenesis of PD in our study. The secretory endometrium contains plenty amount of arachidonic acid, which is used for production of various prostaglandins and leukotrienes during menses.2 9 These prostaglandins and their metabolites are responsible for the symptomatology of PD such as pain, headache, nausea and vomiting, and backache.…”

Section: Discussionmentioning

confidence: 99%

Primer Dismenore Patogenezinde İskemi ve Oksidatif Stresin Rolü

Cinemre

Shundo

Karaca

et al. 2018

Sakarya Medical Journal

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Amaç: Primer dismenore, menstrual dönemde patolojik nedenlere bağlı olmayan ve prostaglandin sentezi tarafından uyarılabilen pelvik ağrıdır. Son çalışmalarda, primer dismenore ile iskemi/hipoksi arasındaki ilişki gösterilmiştir. İskemi Modifiye Albumin (IMA) iskeminin erken döneminin saptanmasında kullanılan yeni bir belirteçtir. Bu çalışmada, iskemi ve oksidatif stresin primer dismenore etiyopatogenezindeki rolünü ve ağrı şiddeti ile ilişkisini araştırmayı planladık.. Yöntem: Bu çalışmaya primer dismenoreli 47 gönüllü tıp fakültesi öğrencisi dahil edildi. Çalışma, Helsinki Deklarasyonu'nda belirtilen esaslara uygun yapıldı ve Etik Komite tarafından onaylandı. Her öğrencinin tam bir fizik ve jinekolojik muayenesi yapıldı. Ağrı şiddetini ölçmek için Görsel Analog Skala (VAS) kullanıldı (ağrı yok-0, hayal edilebilen en şiddetli ağrı-10). Görsel Analog Skala ile, 1-4 arası skorlar hafif; 5-7 arası orta; ve 8-10 arası şiddetli ağrı olarak kabul edildi. Kan örnekleri, menstrüel döneminin üçüncü günü toplandı. Serum ayrıldıktan sonra analiz edilinceye kadar -80 °C'de saklandı. Serum IMA düzeyleri albumin kobalt bağlama (CAB) testi ile ölçüldü ve absorbans üniteleri olarak kaydedildi(AUs). Bu sonuçlar kullanılarak ölçülen serum albümin değerlerine göre düzeltilmiş-IMA (C-IMA) değerleri hesaplandı. C-İMA sonuçları AU/g albumin olarak verildi. Malondialdehit (MDA) düzeyleri tiyobarbitürik asit reaktif madde (TBARS) kullanılarak ölçüldü ve sonuçlar μmol/L olarak verildi.Bulgular: C-IMA değerleri: hafif ağrılı grupta 0.867 ± 0.23; orta ağrılı grupta 1.279 ± 0.31 ve şiddetli ağrılu grupta 1.222 ± 0.20 AU/g albumin bulundu. Oneway ANOVA ile karşılaştırıldığında, grupların ortalamaları arasında anlamlı fark vardı (p <0.024). Tukey testi kullanılarak hafif ağrılı gruptaki C-IMA değerlerinin orta ağrılı olan grubun C-IMA değerlerinden anlamlı derecede düşük olduğu görüldü (p = 0,021). MDA sonuçları: hafif ağrılı grupta 9.01 ± 0.64; orta ağrılı grupta15.20 ± 6.86 ve şiddetli ağrılı grupta 11.78 ± 1.97 μmol/L bulundu. Oneway-ANOVA ile gruplar arasında istatistiksel anlamlı fark vardı (p <0.016). Tukey testi ile grup karşılaştırmaları, hafif dismenoreli grup ile şiddetli ağrılı grup arasında anlamlı fark olduğunu gösterdi (p <0.016).Sonuç: Primer dismenore hastalarında C-IMA ve MDA düzeyleri artmaktadır. Ayrıca, bunların seviyeleri, ağrının şiddeti ile de ilişkiliydi. Bu bulgular, primer dismenorede iskemi ve oksidatif stresin rol oynadığını düşündürmektedir. Muhtemelen ağrı oluşturan mekanizmalar, aynı zamanda oksidatif stres ve iskemiye de neden olmaktadır. İskemi ve ağrı ile birlikte oksidatif stres oluşturan bu mekanizmalar daha ileri araştırmalar ile aydınlatılmalıdır.

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“…However, in our study, the low diagnostic utility of measurements of the oxidative stress marker IMA in T21 pregnancy were demonstrated. Although IMA and AGE have never been measured in T21 pregnancy before, extensive data in the literature suggest their promising diagnostic utility in pre-eclampsia and pregnancy hypertension [57,58]. Despite confirmation of a higher level of oxidative stress, the IMA and AGE levels have been shown to not be remarkably increased in various complications related to T21 gestation [34,42,[59][60][61].…”

Section: Strength and Limitationsmentioning

confidence: 99%

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

Buczyńska

Sidorkiewicz

Ławicki

et al. 2021

JCM

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Despite significant progress in trisomy 21 (T21) diagnostic tools, amniocentesis is still used for the confirmation of an abnormal fetal karyotype. Invasive tests carry the potential risk of miscarriage; thus, screening biomarkers are commonly used before undergoing invasive procedures. In our study, we investigated the possible application of oxidative stress markers in the prenatal screening of trisomy 21. The DNA/RNA oxidative stress damage products (OSDPs), advanced glycation end (AGE) products, ischemia-modified albumin (IMA), alfa-1-antitrypsin (A1AT), asprosin, and vitamin D concentrations were measured in both maternal plasma and amniotic fluid in trisomy 21 (T21) and euploid pregnancies. The obtained results indicated increased levels of DNA/RNA OSDPs and asprosin with simultaneous decreased levels of vitamin D and A1AT in the study group. The diagnostic utility of the plasma measurement based on the area under the received operative characteristic (ROC) curve (AUC) calculation of asprosin (AUC = 0.965), IMA (AUC = 0.880), AGE (AUC = 0.846) and DNA/RNA OSDPs (AUC = 0.506) in T21 screening was demonstrated. The obtained results indicate a potential role for the application of oxidative stress markers in the prenatal screening of T21 with the highest screening utility of plasma asprosin.

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Maternal serum and fetal cord-blood ischemia-modified albumin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis

Cited by 17 publications

References 40 publications

Ischemia-Modified Albumin: Origins and Clinical Implications

Ischemia-Modified Albumin: Origins and Clinical Implications

Primer Dismenore Patogenezinde İskemi ve Oksidatif Stresin Rolü

Prenatal Screening of Trisomy 21: Could Oxidative Stress Markers Play a Role?

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