Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women

Abstract

ObjectiveAngiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum.MethodsSerum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices.ResultsLevels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p <0.01). ANGPTL3 levels do not differ significantly during the three trimesters of pregnancy neither in healthy women nor in preeclamptic women. The serum levels of ANGPTL3 in women who developed preeclampsia are not statistically different from those observed in healthy pregnant women in each trimester of pregnancy. A significant lineal positive correlation was observed between serum ANGPTL3 levels and triglyceride (P =0.0186, r =0.52), very low-density lipoprotein cholesterol (P =0.0224, r =0.50), and total cholesterol levels (P =0.0220, r =0.50) in healthy non-pregnant women (P 0.05). Besides, there were no significant correlations between serum ANGPTL3 and body mass index (BMI), high-density lipoprotein cholesterol, glucose, insulin, leptin, or HOMA-IR (P >0.05)ConclusionsWe describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta.

Elevated angiopoietin-like protein 3 serum levels in diabetic nephropathy patients and its association with renal function and lipid profile

“…In addition to the relation of ANGTPL3 with renal dysfunction, this hepatokine demonstrated a positive relationship with TG levels which is in line with previous findings. There are several lines of evidence that ANGPTL3 is associated with lipid profile and lipoprotein metabolism [ 29 , 30 ], ANGPTL3 indicated a positive association with TG in the Finnish population [ 31 ], patients with polycystic ovary syndrome [ 17 ] preeclamptic pregnant women [ 32 ]. Interestingly, ANGPTL3 showed a relation with proteinuria in patients with hyperlipidemia [ 24 ].…”

Lipid Metabolism in Pregnancy Women with Hypothyroidism and Potential Influence on Pregnancy Outcome

“…Garces et al found that compared with healthy nonpregnant and postpartum women, serum ANGPTL3 levels were significantly lower in healthy pregnant women from the first trimester to the third trimester. It was speculated that serum ANGPTL3 may be involved in the changes of lipid metabolism in the anabolic and catabolic stages of pregnancy, which may help placental hormones become the main driving factor to regulate maternal lipid metabolism during pregnancy [ 53 ]. However, there was no significant difference in circulating concentrations of ANGPTL4 [ 52 ].…”

Clinical characteristics and laboratory data of pre-eclampsia patients with and without in vitro fertilization embryo transfer treatment

“…These changes are essential for fetal growth and delivery. However, the situation is complicated by the pre-eclampsia [14][15][16]. Several studies have already summarized the clinical characteristics of the general pre-eclampsia population [17,18].…”