Maternal serum corticotropin‐releasing hormone and ACTH levels as predictive markers of premature labor

Makrigiannakis, Antonis; Semmler, María Eugenia Aubet; Briese, Volker; Eckerle, H.; Minas, Vassilis; Mylonas, Ioannis; Friese, Klaus; Jeschke, Udo

doi:10.1016/j.ijgo.2007.01.007

Cited by 46 publications

(33 citation statements)

References 25 publications

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“…The synergistic stimulation of the feto-placental unit and the pituitary adrenal axis of both fetus and mother play a pivotal role in initiation of parturition [4,5]. Our study is in accordance with Makrigiannakis et al who demonstrated the role of serum ACTH levels as predictive marker for premature labor [6]. Ferritin, an iron storage protein, is an acute phase reactant.…”

Section: Discussionsupporting

confidence: 92%

Potential Biochemical Markers for Preterm Labor: A Pilot Study in North India

et al. 2010

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Preterm delivery is a major contributor for neonatal mortality. Intensive research is underway to establish a reliable biomarker that can ascertain the risk of preterm delivery in pregnant women. The aim of our study was to evaluate the role of various biochemical parameters as potential biomarker for risk assessment for preterm labor. Forty women presenting with preterm labor and 40 women who delivered at term were included in the study. Parameters that were evaluated include corticotrophin (ACTH), prolactin, thyroid stimulating hormone (TSH), ferritin and Alkaline Phosphatase (ALP). Serum ACTH, ferritin, ALP and Ferritin/Iron ratio were significantly higher in the subjects who delivered prematurely as compared to the controls. Comparison of sensitivity, specificity, likelihood ratio, positive and negative predictive values for different cut offs for ACTH, ferritin, ALP and ferritin/iron ratio was carried out. Ferritin emerged as the best marker with area under curve of 0.96 as compared to 0.88 for ACTH, 0.825 for ALP and 0.735 for ferritin/iron ratio. Our study establishes the superiority of ferritin as a predictive biomarker for preterm labor as compared to the rest of the parameters evaluated.

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Section: Discussionsupporting

confidence: 92%

Potential Biochemical Markers for Preterm Labor: A Pilot Study in North India

et al. 2010

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“…42 Other studies have found associations between stress hormones (i.e., cortisol and adrenocorticotrophin-releasing hormone) and PTB, though IPV as a stressor was not specifically measured. [43][44][45] These findings highlight the need for further research on the neuroendocrine changes evident in pregnant women experiencing IPV. An enhanced understanding of the links between violence, HPA activation, utero-placental perfusion, and adverse neonatal outcomes may provide an important pathway to reducing disparities in neonatal outcomes.…”

Section: Severity Of Violence and Adverse Neonatal Outcomesmentioning

confidence: 89%

Intimate Partner Violence During Pregnancy and Adverse Neonatal Outcomes in Low-Income Women

Alhusen

Bullock

Sharps

et al. 2014

Journal of Women's Health

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Background: Intimate partner violence (IPV) affects an estimated 1.5 million U.S. women annually. IPV impacts maternal and neonatal health with higher rates of depression and low birth weight (LBW). Less studied is experiencing IPV and delivering a small for gestational age (SGA) baby. SGA neonates are at increased risk of developmental and behavioral problems. The negative sequelae persist into adulthood with increased rates of diabetes mellitus and coronary heart disease. Methods: In a sample of 239 pregnant women experiencing IPV, in urban and rural settings, we examined cross-sectional associations of severity of IPV and neonatal outcomes (i.e., birth weight and gestational age). Severity of IPV was measured by the Conflict Tactics Scale 2 and neonatal outcomes were collected at the time of delivery. Results: Outcomes were collected on 194 neonates; 14.9% (n = 29) were classified as LBW, 19.1% (n = 37) classified as SGA, and 9.8% (n = 19) as LBW and SGA. Women reporting higher severity of IPV during pregnancy had a greater likelihood of delivering an SGA neonate (odds ratio [OR] 4.81; 95% confidence interval [95% CI] 1.86-12.47), and LBW neonate (OR 4.20;. Conclusions: In a sample of pregnant women experiencing perinatal IPV, women experiencing greater severities of IPV were more likely to deliver a neonate with an adverse outcome. Early recognition and intervention of IPV is essential to reduce disparities in birth outcomes and long-term health outcomes for these neonates.

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“…At the physiological level, it is clear that many factors are involved in the onset of labor, including hormonal metabolism and structural changes to the uterus and myometrium (Petraglia et al, 1996) but the effects and interactions among these factors are not fully understood (Challis, 1994). Research from our group Sandman et al, 2006;Sandman et al, 1995Sandman et al, , 1999bWadhwa et al, 1996;Wadhwa et al, 2004;Wadhwa et al, 1998) and many others (Braastad, 1998;Lindsay & Nieman, 2005;Makrigiannakis et al, 2007;Neumann et al, 1998) indicates that a primary pathway of the effects of stress on the human fetus is the HPA stress axis. This review will focus on the role that stress plays in determining preterm birth.…”

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confidence: 91%