Maternal serum creatine kinase: A possible predictor of tubal pregnancy

Lavie, Ofer; Beller, Uziel; Neuman, Menahem; Ben-Chetrit, Avraham; Gottcshalk-Sabag, Shoshana; Diamant, Yoram Z.

doi:10.1016/0002-9378(93)90272-k

Cited by 53 publications

(45 citation statements)

References 2 publications

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“…The first study of CK as a marker of Fallopian Serum biomarkers of tubal ectopic pregnancy tube damage produced some encouraging results (Lavie et al 1993). Serum CK concentrations were significantly higher in those with tubal pregnancy (nZ17) as opposed to those with missed abortion (nZ17) or normal pregnancy (nZ17).…”

Section: Creatine Kinasementioning

confidence: 93%

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Cartwright¹,

Duncan²,

Critchley³

et al. 2009

Reproduction

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Ectopic pregnancy remains a considerable cause of maternal morbidity and mortality worldwide. Currently, it is diagnosed using a combination of transvaginal ultrasound and serial serum b-human chorionic gonadotrophin levels. Diagnosis is often delayed and these tests are time-consuming and costly, both psychologically to the patient and financially to health services. The development of a biomarker that can differentiate a tubal ectopic from an intrauterine implantation is therefore important. In the pre-genomic era, a one-by-one scientific approach has revealed over 20 candidate biomarkers that could be used as a test to diagnose ectopic pregnancy although at present their clinical utility is very limited. These biomarkers cluster into themes: markers of abnormal embryo/trophoblast growth, markers of abnormal corpus luteum function, markers of a growing pregnancy in the Fallopian tube, markers of inflammation and peritoneal irritation, and uterine markers of normal implantation. It is likely that this thematic approach will facilitate the identification of newer biomarkers using microarray technology and inform the development of investigative paradigms using multiple markers at the time of presentation.

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Section: Creatine Kinasementioning

confidence: 93%

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Cartwright¹,

Duncan²,

Critchley³

et al. 2009

Reproduction

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“…13 Lavie et al, Chandra et al and Saha et al also found the mean Cpk levels of ectopic pregnancies to be significantly higher than the control groups. [4][5][6] In present study, the CPK levels were compared between ruptured and unruptured tubal ectopics and the mean CPK levels in ruptured (97.26±25.97) were higher than unruptured (63.82±34.92) which was statistically significant(p=0.015). However, studies with large study population are required to further validate the findings.…”

Section: Discussionmentioning

confidence: 68%

“…CPK is an intracellular metabolic enzyme which catalyses adenosine triphosphate (ATP) production from creatine phosphate and Adenosine diphosphate(ADP) necessary for the contractile system. 3 Lavie et al first brought CPK into limelight as a possible marker of smooth muscle damage in ectopic pregnancy (4). Since then many studies were undertaken some with total CPK and some others with isoenzymes like CPK-MM and CPK-MB.…”

Section: Introductionmentioning

confidence: 99%

CPK: The new tool in the diagnosis of ectopic pregnancy

Ganta

Kulkarni

Muralidhar

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Ectopic pregnancy is still a diagnostic dilemma presenting with various complaints. The classic triad of amenorrhea, abdominal pain, vaginal bleeding and /or syncope is not always seen. Misdiagnosis can lead to delay in treatment, blood loss is found to be the major cause of death. Early and accurate diagnosis is critical in bringing down the maternal mortality and morbidity. Prompt and effective treatment of an ectopic pregnancy can help preserve the chances of future healthy pregnancies. Aim of present study was to investigate whether creatinine phosphokinase (cpk) can be used as an effective diagnostic tool in the early diagnosis of ectopic pregnancy which can help in decreasing the maternal mortality and morbidityMethods: This observational comparative three group clinical study was conducted at Chinmaya Mission Hospital, Bangalore, between May 2016 to January 2017.120 women in their early trimester were studied of which 40 were diagnosed cases of ectopic pregnancies, 40 women presented with intrauterine abortive pregnancies and 40 women had normal healthy pregnancies. Serum CPK, serum B-HCG, vaginal scans were done in all, along with routine investigations.Results: The mean CPK values in normal, abortive and ectopic pregnancies were 36.92±6.44, 43.95±11.96 and 91.55±30.43 respectively. It was found to be significantly higher in ectopic Pregnancies. Also, the mean CPK in ruptured and unruptured ectopic pregnancy were 97.26±25.97 and 63.82±34.92 respectively.Conclusions: Present study shows that maternal CPK levels are significantly higher in women with ectopic pregnancies. CPK can serve as the reliable biochemical marker to diagnose ectopic pregnancy particularly ruptured. CPK can be used to increase the diagnostic efficacy in ectopic pregnancy, which followed by rapid and appropriate treatment can reduce the mortality, morbidity and preserve future fertility.

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“…So far, different biochemical markers have been tested for their clinical value in the diagnosis of ectopic versus early intrauterine pregnancy: placental protein 14 [5], prorenin [8], active renin [8], intact hCG [7], free ßhCG [7], progesterone [6,7] and creatine kinase [9][10][11][12]. Only levels of placental protein 14 [5] and active renin [8] were significantly different comparing ectopic pregnancies and early missed abortions, although no discriminating cut-off level could be determined.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, several investigators have looked for biochemical tests to improve the diagnosis of ectopic pregnancy. Various pregnancy-associated proteins [4,5], progesterone [6,7], renin [8], free ßhCG [7] and creatine kinase [9][10][11][12] have been investigated, but none have been sufficiently sensitive and specific to be of clinical value.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Intrauterine Human Decidua-Associated Protein 200 and Diagnosis of Ectopic Pregnancy

Halperin

Hadas²,

Bukovsky³

1998

Gynecol Obstet Invest

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The aim of the current study was to examine whether the measurement of intrauterine human decidua-associated protein (hDP) 200 might be of clinical value in the diagnosis of ectopic pregnancy versus early missed abortion. Uterine fluid levels of hDP 200 were measured in two groups of patients: 20 women with ectopic pregnancy, diagnosed by laparoscopy, and 20 women diagnosed (after curettage) as having a missed abortion. No significant difference in hDP 200 levels was observed comparing patients with ectopic pregnancy (mean 114.0 ± 58.2 mU/ml) and patients with early missed abortion (mean 222.0 ± 116.0 mU/ml), although a trend towards lower levels of uterine fluid hDP 200 was noted in the group of patients presenting with tubal pregnancy. Thus, according to our data, intrauterine hDP 200 is not sufficiently discriminative to be of clinical value in the diagnosis of ectopic pregnancy.

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Maternal serum creatine kinase: A possible predictor of tubal pregnancy

Cited by 53 publications

References 2 publications

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

CPK: The new tool in the diagnosis of ectopic pregnancy

Measurement of Intrauterine Human Decidua-Associated Protein 200 and Diagnosis of Ectopic Pregnancy

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