Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: a prospective cohort study

Gulati, Shilpa; Agrawal, Swati; Chitra, R.; Bhattacharya, J.; Saili, Arvind; Agarwal, Shilpi; Sharma, Deepika

doi:10.3109/14767058.2011.638952

Cited by 31 publications

(34 citation statements)

References 17 publications

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“…This is truly important in under-developing countries in which there is no access to invasive procedures for an accurate diagnosis of HCA, such amniocentesis or vaginal amniotic fluid analysis. In 1997, Shimoya et al [29] found maternal serum concentrations of IL-8 as a screening marker for HCA, while similarly to our study, most authors agree that women with PPROM have higher serum levels of IL-6 [9,13,16,18,19,29].…”

Section: Discussionsupporting

confidence: 49%

“…In cases of intrauterine infection, cytokines produced within the uterine cavity first mount a local inflammatory response, and then reach the maternal circulation and the liver to stimulate the synthesis of C-reactive protein (CRP) by hepatocytes or bone marrow targets to induce leukocytosis [11][12][13]. Therefore, a rise in cytokines occurs earlier than CRP [14].…”

Section: Introductionmentioning

confidence: 99%

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Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

et al. 2018

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Objective: To assess the added value of maternal serum levels of IL-6 in women with preterm-prelabor rupture of membranes (PPROM) as a non-invasive test for the prediction of histological chorioamnionitis (HCA). Methods: This was a prospective cohort study of pregnant women between 20 + 0 and 36 + 6 weeks of gestation with a confirmed diagnosis of PPROM. Logistic regression models were created for the prediction of HCA and compared by assessing the improvement in their Naegelkerke R² as a measure of goodness of fit. Predictive performance of all models was assessed by receiver operating characteristics curve (ROC) analysis and compared by the DeLong method. Results: From 47 women with PPROM, 31 (66%) developed HCA. Maternal serum IL-6 ≥19.5 pg/dL was the best cut-off point for the prediction of HCA (OR = 15; 95% CI: 3.6–61; p < 0.01). A model comprising maternal characteristics and IL-6 ≥19.5 pg/dL showed an area under the curve of 0.85 (95% CI: 0.74–0.95), significantly improving the previous models of IL-6 ≥19.5 pg/dL (R²: 23.3 vs. 34.1%; p = 0.01) or maternal characteristics (R²: 8.4 vs. 34.1%; p < 0.01). Conclusions: A model comprising maternal serum levels of IL-6 plus maternal characteristics proves to be a good non-invasive predictor of HCA.

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Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

et al. 2018

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“…11,12 Other markers of inflammation detectable in the amniotic fluid or fetal membranes have previously been examined in the setting of suspected intrauterine infection; however, to date they have not had adequate utility to translate into regular clinical practice. 8,13,14 Sampling these tissues requires invasive procedures likely to be accepted by a limited number of women concerned about the potential harm from such procedures. 15,16 We undertook a prospective study where we set out to identify an mRNA-based biomarker in maternal blood that can identify the presence of chorioamnionitis in utero, among women who had PPROM.…”

Section: Discussionmentioning

confidence: 99%

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

et al. 2015

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Background: Preterm prelabor rupture of the fetal membranes (PPROM) is a significant contributor to the morbidity and mortality of preterm birth, particularly in the setting of chorioamnionitis. No sensitive or specific diagnostic or predictive test currently exists for the accurate diagnosis of chorioamnionitis. Our aim was to measure messenger RNA (mRNA) coding cytokines in the maternal blood and examine whether they were increased in association with chorioamnionitis at delivery. Methods/Results: We performed a prospective cohort study of women recruited with PPROM at a mean gestational age of 28.9 weeks at risk of developing chorioamnionitis. Blood was sampled from participants, and the expression of mRNA coding for proinflammatory genes was measured in women with and without chorioamnionitis at the time of delivery as well as gestationmatched healthy controls. Expression was measured using quantitative polymerase chain reaction (PCR) and also digital PCR. Interleukin 1b (IL1B) mRNA expression in maternal blood was elevated in women with chorioamnionitis compared to gestation-matched controls. Importantly, among women admitted with PPROM, digital PCR confirmed a significant increase in IL1B expression in maternal blood in women with chorioamnionitis compared to women without chorioamnionitis. Polymerase chain reaction array revealed that CD14, nuclear factor of k light polypeptide gene enhancer in B-cells 1 (NFKB1), and tumor necrosis factor receptor super family-interacting serine-threonine kinase 1 mRNA were significantly increased in women with chorioamnionitis compared to controls. Digital PCR confirmed that NFKB1 mRNA was significantly increased in patients with chorioamnionitis compared to controls and that CD14 levels increased over time in patients with PPROM having chorioamnionitis. Conclusion: Measuring circulating proinflammatory mRNA in women with PPROM may distinguish those with chorioamnionitis from those without, in turn providing better targeted therapies and appropriate timing of delivery.

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“…uPAR enfeksiyondan korunmada önemli bir moleküldür. Özellikle lökosit adhezyon ve migrasyonunu tetikleyerek immün defans› güçlendirir (17) . Savva ve arkadafllar› sepsisli hastalarda yapt›klar› ça›lflmada sepsis tan›s› ve ciddiyetinin tahmininde yüksek serum uPAR düzeyleri ile iliflkili oldu¤unu göstermifllerdir (18) .…”

Section: G‹r‹fiunclassified

THE ROLE OF uPAR,ST2,IL-33,IL-6 FOR THE DIAGNOSIS OF PRETERM PREMATURE RUPTURE OF MEMBRANES

Çekmez¹,

Öcal²,

Özkaya³

et al. 2013

J Turk Soc Obstet Gynecol

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Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: a prospective cohort study

Abstract: Maternal serum IL-6 can be used as a biomarker to predict preclinical asymptomatic infection in PPROM with good sensitivity and specificity.

Cited by 31 publications

References 17 publications

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

Maternal Serum Interleukin-6: A Non-Invasive Predictor of Histological Chorioamnionitis in Women with Preterm-Prelabor Rupture of Membranes

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

THE ROLE OF uPAR,ST2,IL-33,IL-6 FOR THE DIAGNOSIS OF PRETERM PREMATURE RUPTURE OF MEMBRANES

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