Maternal Serum Interleukin-6 During Pregnancy and During Term and Preterm Labor

Greig, Phillip C.; Murtha, Amy P.; Jimmerson, Cathy J; Herbert, William N.P.; Roitman-Johnson, B.; Allen, Jean

doi:10.1016/s0029-7844(97)00294-9

Cited by 115 publications

(78 citation statements)

References 17 publications

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“…221 There were five studies, all in symptomatic women who presented with threatened preterm labour, which evaluated serum IL-6 as a predictor for spontaneous preterm birth. 235,[237][238][239][240] Two studies provided information for more than one category of either population 103 or type of IL-6 specimen. 235 Appendix 5, Table 92 summarises individual study characteristics.…”

Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Section: Study Characteristics and Qualitymentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

View full text Add to dashboard Cite

show abstract

“…This could be explained by the fact that IL-6 has both pro-and antiinflammatory properties. The classification of IL-6 as a Th1-type cytokine in studies on preterm labor 56,57 or as a Th2 type cytokine in early pregnancy [58][59][60][61] remains controversial. Recently, it has been demonstrated that IL-6 is involved in the promotion of Th2 differentiation and the inhibition of Th1 polarization.…”

Section: Commentmentioning

confidence: 99%

Pro- and antiinflammatory cytokines in threatened miscarriages

Calleja‐Agius

Muttukrishna

Pizzey

et al. 2011

American Journal of Obstetrics and Gynecology

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OBJECTIVE:The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome.STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF␣, interferon gamma (IFN␥), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS:Monocyte expression of TNF␣ and circulating levels of TNF␣, IFN␥, IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF␣/IL-10, IFN␥/IL-10, and TNF␣/IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome.CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage.

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“…3,[157][158][159][160][161] It has also earned the role of diagnostic marker in periodontal disease. 162,163 A study of murine maternal responses to P. gingivalis during pregnancy 164 showed that P. gingivalis dissemination to the uterus has to occur for fetal growth retardation (FGR).…”

mentioning

confidence: 99%

Oral colonization of Gram-negative anaerobes as a risk factor for preterm delivery

Africa¹

2011

Virulence

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Maternal Serum Interleukin-6 During Pregnancy and During Term and Preterm Labor

Abstract: Compared with antepartum gravidas, those in term or preterm labor had significantly higher concentrations of maternal serum interleukin-6 concentrations; extremely elevated levels were found in patients whose preterm labor was associated with intrauterine infection.

Cited by 115 publications

References 17 publications

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Pro- and antiinflammatory cytokines in threatened miscarriages

Oral colonization of Gram-negative anaerobes as a risk factor for preterm delivery

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