Maternal serum iron status, hepcidin and interleukin-6 levels in women with preeclampsia

Abstract

Introduction: Preeclampsia can lead to a number of adverse maternal and perinatal effects. The association between iron status [serum iron, ferritin and total iron-binding capacity (TIBC)], unsaturated iron-binding capacity, hepcidin, interleukin-6 (IL-6) levels and preeclampsia is not fully understood.Objective: To assess the levels of iron status, hepcidin and interleukin-6 in women with preeclampsia compared with healthy pregnant women.Method: A case-control study (60 women were recruited in each group) was conducted at Saad Abuelela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The levels of iron status, hepcidin and IL-6 were measured using applicable methods.Results: There was no significant difference in the median [interquartile range (IQR)] of age, parity or body mass index between the two groups. Moreover, the median (IQR) of the iron status, hepcidin and interleukin-6 did not differ between women with preeclampsia and healthy controls. There were no significant correlations between haemoglobin, hepcidin and IL-6. There were also no significant correlations between serum iron, serum ferritin, hepcidin and IL-6. However, there was a significant positive correlation between hepcidin and IL-6 (r = 0.393, p = 0.002).Conclusion: In this study, women with preeclampsia had levels of iron status, hepcidin and IL-6 similar to those observed in healthy pregnant women. There was no significant correlation between iron status, hepcidin and IL-6.

Analysis of Hepcidin and Interleukin-6 Levels among Transfusion-Dependent Thalassemia Patients With and Without Alloimmunization/Autoimmunization

“…The disparity in hepcidin and IL-6 levels between the two groups revealed a significant difference (p < 0.05), with the alloimmunization/autoimmunization TDT group exhibiting elevated hepcidin and IL-6 levels compared to the group without alloimmunization/autoimmunization. These findings align with research conducted in Australia and other studies that reported differences and increased levels of hepcidin 19,21,[35][36][37] and IL-6 [38][39][40] in TDT patients compared to NTDT patients. This discrepancy arises from alloantigen stimulation resulting from repeated blood transfusions, showcasing a substantial difference and higher levels in the TDT group.…”