Maternal serum levels of free β-hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery

Morssink, Leonard P.; Kornman, Louise; Hallahan, Terrence; Kloosterman, M. D.; Beekhuis, J. R.; Wolf, B. T. H. M. De; Mantingh, A.

doi:10.1002/(sici)1097-0223(199802)18:2<147::aid-pd231>3.0.co;2-w

Cited by 81 publications

(49 citation statements)

References 22 publications

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“…In contrast, other studies have found an association between low PAPP-A and increased risk of low birth weight or intrauterine growth retardation, but not with preterm birth (Ong et al, 2000;Yaron et al, 2002a;Kwik and Morris, 2003;Tul et al, 2003). Furthermore, Morssink et al (1998) concluded that PAPP-A is not associated with either fetal growth restriction or preterm delivery.…”

Section: Low Papp-a and Adverse Outcomesmentioning

confidence: 82%

Use of the combined first‐trimester screen result and low PAPP‐A to predict risk of adverse fetal outcomes

Barrett¹,

Bower

Hadlow³

2008

Prenatal Diagnosis

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ObjectivesTo investigate associations between combined first‐trimester screen result, pregnancy associated plasma protein‐A (PAPP‐A) level and adverse fetal outcomes in women.MethodsPregnancy outcomes for 10 273 women participating in a community based first‐trimester screening (FTS) programme in Western Australia were ascertained by record linkage to birth and birth defect databases. A first‐trimester risk cut‐off of ≥ 1 in 300 defined screen positive women.ResultsScreen positive pregnancies were more likely to have Down syndrome and birth defects (chromosomal or nonchromosomal) than screen negative pregnancies. When birth defects were excluded, screen positive pregnancies were at increased risk of pregnancy loss, low birth weight and preterm birth. Pregnancies with low PAPP‐A (⩽0.3 multiples of the median (MoM)) had higher risk of chromosomal abnormality, birth defect, preterm birth, low birth weight, or pregnancy loss, compared to those with PAPP‐A > 0.3 MoM. In pregnancies without birth defects, low PAPP‐A was a stronger predictor of preterm birth, low birth weight or pregnancy loss than a screen positive result.ConclusionsWomen with positive screen or low PAPP‐A were at increased risk for some adverse fetal outcomes. The sensitivity of these parameters was insufficient to support primary screening, but increased surveillance during pregnancy may be appropriate. Copyright © 2008 John Wiley & Sons, Ltd.

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Section: Low Papp-a and Adverse Outcomesmentioning

confidence: 82%

Use of the combined first‐trimester screen result and low PAPP‐A to predict risk of adverse fetal outcomes

Barrett¹,

Bower

Hadlow³

2008

Prenatal Diagnosis

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show abstract

“…The association between maternal serum analytes and abnormal pregnancy/neonatal outcomes is controversial [2,4,9,10]. The use of maternal serum screening solely to predict and prevent these outcomes has not been supported due to overall low sensitivity and high false-positive rates [11,12].…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Aneuploidy Screen and Adverse Pregnancy Outcomes

Godbole

Kulkarni

Kanade

et al. 2016

J Obstet Gynecol India

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Objective To find out whether maternal serum screening for fetal chromosomal aneuploidy predicts adverse pregnancy outcomes. Methods A two-year retrospective case-control study was conducted at a tertiary hospital. Pregnant women with a high-risk serum screen but with chromosomally normal fetuses (n = 189) were compared to those with low-risk screen (controls, n = 157) for adverse pregnancy outcomes. p \ 0.005) and gestational age (R 2 = 4.9 %, b ± SE = 0.613 ± 0.296; p \ 0.05). Beta hCG in first and hCG in second trimester predicted oligohydramnios (R 2 = 9.2 %, b ± SE = -0.077 ± 0.025; p \ 0.005). The areas under the ROC curves of PAPP-A for LBW and PT were 0.70(p \ 0.01) and 0.684 (p \ 0.05), respectively. Conclusion A ''high-risk'' maternal serum screen with abnormal PAPP-A and/or beta hCG/HCG is associated with adverse pregnancy outcomes and may help identifying women requiring additional fetal surveillance.

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“…Morssink ve ark. (30) yaptığı çalışmada, ilk trimesterda ölçülen düşük PAPP-A değerleri ile preterm eylem arasında ilişki bulunmamıştır. Smith ve ark.…”

Section: Discussionunclassified

“…Yapılan çalışmalarda, ilk trimesterde ölçülen maternal serum PAPP-A ve B-HCG değerlerinin gebelik komplikasyonlarıyla ilişkisi araştırılmış ve farklı sonuçlar bulunmuştur. Preeklampsi ile ilgili olarak çok sayıda yayın mevcut olup, PAPP-A değerlerinde-ki düşüşün anlamlı olduğu belirtilmiştir (5) . Literatürde yer alan diğer çalışmalarda, gebelik komplikasyonlarından, gestasyonel diyabet, düşük doğum ağırlığı, yüksek doğum ağırlığı, intrauterin gelişme geriliği ve preterm eylem ile maternal serum PAPP-A ve B-HCG değerleriyle anlamlı ilişkiler saptanmıştır (3)(4)(5) .…”

Section: Introductionunclassified

Role of Pregnancy Associated Plasma Protein (PAPP-A) and Free Human Chorionic Gonadotropin (B-HCG) in Predicting Adverse Pregnancy Outcomes

Yıldız¹,

Şahin²

2015

IKSST

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Maternal serum levels of free β-hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery

Cited by 81 publications

References 22 publications

Use of the combined first‐trimester screen result and low PAPP‐A to predict risk of adverse fetal outcomes

Use of the combined first‐trimester screen result and low PAPP‐A to predict risk of adverse fetal outcomes

Maternal Serum Aneuploidy Screen and Adverse Pregnancy Outcomes

Role of Pregnancy Associated Plasma Protein (PAPP-A) and Free Human Chorionic Gonadotropin (B-HCG) in Predicting Adverse Pregnancy Outcomes

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