Maternal serum lipid in women with preeclampsia in Lagos: a case control study

Olalere, Haleema Folasade; Okusanya, BO; Oye-Adeniran, BA

doi:10.1080/14767058.2018.1505851

Cited by 11 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this review, the following factors were identified as a risk factors for preeclampsia and eclampsia: paternity [ 25 , 40 ], marital status [ 49 ], HIV/AIDS [ 36 , 41 ], place of residence [ 34 , 40 , 57 ], family size [ 13 , 51 ], maternal sleeping position [ 22 ], blood type [ 45 , 64 ], H. pylori seropositivity [ 16 ], distance from health facility [ 52 ], placental malaria [ 64 ] and seasonal variation [ 19 ]. In addition, recently several researchers investigated the genetic components and related predisposing factors for preeclampsia and eclampsia in African women [ 16 , 20 , 23 , 31 , 33 , 35 , 37 , 43 , 55 , 56 , 59 , 61 – 63 ]. However, this systematic review was not found sufficient evidence to draw strong conclusion to consider them as a risk factor for preeclampsia/eclampsia.…”

Section: Resultsmentioning

confidence: 99%

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

et al. 2020

View full text Add to dashboard Cite

Background Preeclampsia and eclampsia are common complications of pregnancy globally, including sub-Saharan African (SSA) countries. Although it has a high burden on maternal and neonatal mortality and morbidity, evidence on the risk of the problem is limited. Therefore, the aim of this review was to examine the factors associated with preeclampsia and eclampsia among mothers in SSA countries. Methods We searched article from SSA countries using electronic database MEDLINE, EMBASE, PubMed, CINAHL published in English from January 2000 to May 2020. Two reviewers independently screened, extracted and assessed the quality of the articles. Both random and fixed effect model were used for analysis. Heterogeneity of the studies and publication bias were checked. STATA 16 used for analysis. Results Fifty-one studies met the inclusion criteria and included in this review. The following factors were identified through meta-analysis: being primiparous (

show abstract

Section: Resultsmentioning

confidence: 99%

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this sub-categorical analysis 15 studies were included to compare the serum HDL-c levels between pre-eclamptic and normotensive pregnant women [12,14,15,[20][21][22][23][24][25][26][27][28][29][30][31]. Nine of the included studies [12,15,20,21,25,26,28,30,31] showed significantly lower levels of serum HDL-c and three studies [22,24,27] showed higher levels of serum HDL-c in pre-eclamptic group as compared to normotensive pregnant women but, three studies [14,23,29] did not show a significant association between serum HDL-c and pre-eclampsia. The pooled metaregression analysis showed that there is a statistical significant association between serum levels of HDL-c and pre-eclampsia as compared to normotensive pregnant women with the pooled SMD of -0.91 (95% CI: -1.43, -0.39) (Fig 4).…”

Section: Association Of Serum Hdl-cholesterol With Pre-eclampsiamentioning

confidence: 99%

“…In this sub-categorical analysis 15 studies were included to compare the serum LDL-cholesterol levels between pre-eclamptic and normotensive pregnant women [12,14,15,[20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Association Of Serum Ldl-cholesterol With Pre-eclampsiamentioning

confidence: 99%

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

View full text Add to dashboard Cite

Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

show abstract

“…(Benny et al 2020; Ching et al 2015, 2014). However, the systematic changes in lipids, which are more stable compared to other metabolites, are less studied for preeclampsia (S. M. Lee et al 2019; Olalere, Okusanya, and Oye-Adeniran 2020; Spracklen et al 2014). Lipids have shown biomarker potentials for many diseases (Balogh et al 2010; Görke et al 2010; Han et al 2007; Pietiläinen et al 2007; Zhou et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…(Benny et al 2020;Ching et al 2015Ching et al , 2014. However, the systematic changes in lipids, which are more stable compared to other metabolites, are less studied for preeclampsia (S. M. Lee et al 2019;Olalere, Okusanya, and Oye-Adeniran 2020;Spracklen et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia

Liu

Maurya

et al. 2020

Preprint

View full text Add to dashboard Cite

Preeclampsia is a pregnancy specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. To reveal the relationship between lipids and preeclampsia, we conduct lipidomic profiling of maternal serums of 44 severe preeclamptic and 20 healthy pregnancies from a multi-ethnic cohort in Hawaii. Correlation network analysis shows that oxidized phospholipids (OxPLs) have increased inter-correlations and connections in preeclampsia, while other lipids, including triacylglycerols (TAGs), have reduced network correlations and connections. Thirty-one lipid species from various lipid classes demonstrate predominantly reductions and causal relationships with preeclampsia. They include phosphatidylglycerol (PG), TAG, diacylglycerol (DAG), phosphatidylcholine (PC), cholesterol esters (CE), phosphatidylethanolamine (PE), sphingomyelin (SM), ceramides (Cer-NS), hexosyl ceramides (HexCer-NS), lysophosphatidylcholine (LPC), lysophosphatidylethanolamine (LPE), and free fatty acid (FFA). Many of these lipids are also selected as important features by a linear discriminant analysis (LDA) classifier with high predictive accuracy (F-1 statistic 0.941 and balanced accuracy 0.88), indicating their potential to serve as biomarkers for severe preeclampsia. Our study supports the hypothesis of a phospholipid (PL) centered, dysregulated lipidomic metabolic atlas. That is, severe preeclampsia may be originated from hypoxia, which induces the accumulation of OxPLs through oxidative stress whereas reduces many other lipids (eg. reduced PCs, TAGs and ceramides). These molecular changes coherently lead to dysregulated biological functions, such as insulin signaling and inflammation/infections. Moreover, the lipid changes may also be responsible for the comorbidity between preeclampsia and gestational diabetes, a clinically known risk factor for preeclampsia.

show abstract

Maternal serum lipid in women with preeclampsia in Lagos: a case control study

Abstract: There is elevated serum lipid in pregnancy irrespective of preeclampsia developing. The positive correlation of maternal serum lipids to preeclampsia suggests a casual relationship.

Cited by 11 publications

References 14 publications

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Maternal blood lipidomics analyses link critical metabolic pathways associated with severe preeclampsia

Contact Info

Product

Resources

About