Maternal serum progesterone, estradiol and estriol levels in successful dinoprostone-induced labor

Abstract

Hormone-mediated quiescence involves the maintenance of a decreased inflammatory responsiveness. However, no study has investigated whether labor induction with prostanoids is associated with changes in the levels of maternal serum hormones. The objective of this study was to determine whether labor induction with dinoprostone is associated with changes in maternal serum progesterone, estradiol, and estriol levels. Blood samples were obtained from 81 pregnant women at term. Sixteen patients had vaginal birth after spontaneous labor, 12 required cesarean section after spontaneous labor and 16 underwent elective cesarean. Thirty-seven patients had labor induction with dinoprostone. Eligible patients received a vaginal insert of dinoprostone (10 mg) and were followed until delivery. Serum progesterone (P4), estradiol (E2) and estriol (E3) levels and changes in P4/E2, P4/E3 and E3/E2 ratios were monitored from admission to immediately before birth, and the association of these measures with the resulting clinical classification outcome (route of delivery and induction responsiveness) was assessed. Progesterone levels decreased from admission to birth in patients who underwent successful labor induction with dinoprostone [vaginal and cesarean birth after induced labor: 23% (P , 0.001) and 18% (P , 0.025) decrease, respectively], but not in those whose induction failed (6.4% decrease, P . 0.05). Estriol and estradiol levels, P4/E2, P4/E3 and E3/E2 ratios did not differ between groups. Successful dinoprostone-induced labor was associated with reduced maternal progesterone levels from induction to birth. While a causal relationship between progesterone decrease and effective dinoprostone-induced labor cannot be established, it is tempting to propose that dinoprostone may contribute to progesterone withdrawal and favor labor induction in humans.

Castor oil Induces Morphological Changes in Endometrium and Biochemical Parameters in Pregnant Wistar Rats

“…Furthermore, the result of our study recorded a significant decrease in serum progesterone level in the high dose castor oil and the castor oil + misoprostol group. The result of this study is in congruent with the work of (22) where they reported that a dinoprostoneinduced labour was associated with reduced maternal progesterone levels from induction to birth.…”

The impact of progesterone and RU-486 on classic pro-labour proteins & contractility in human myometrial tissues during 24-hour exposure to tension & interleukin-1β

“…An alternative and currently more accepted theory for how myometrial P4 action is reduced at labour is that of P4 'functional withdrawal', whereby the myometrium is suppressed in its ability to mediate the pro-quiescent effects of P4 at labour despite no change in its concentrations (Astle et al , 2003, Challis et al , 2000, Konopka et al , 2013, Lofgren and Backstrom, 1997, Rae et al , 2007. This P4 functional withdrawal theory is predominantly associated with the opposing effects of P4 receptor (PR) isoforms A (PR-A) and B (PR-B) demonstrated in myometrial cells, whereby PR-B mediates the pro-gestational effects of P4 and PR-A dimerises with PR-B to inhibit its activity whilst also controlling the expression of pro-inflammatory mediators independently of PR-B (Merlino et al , 2007, Peters et al , 2017, Pieber et al , 2001, Tan et al , 2012.…”

Effect of Aqueous Extract of Naja naja Sp. Shedded Skin in Pregnant Female Rats and its Role on the Growth and Development in the Pups

“…In the SSS(5) treated pups, the eyes were not developed indicating that SSS had passed feto-placental barrier, caused growth restriction and hampered the developmental process. SSS(10) due to feto-placental passage caused fetal resorption by recruiting the inflammatory markers [15,16].…”