Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

Tayyar, Ahter Tanay; Tayyar, Ahmet; Kozalı, Şükran; Karakuş, Resul; Eser, Ahmet; Yayla, Cigdem Abide; Yalçın, Emel Tuğçe; Dağ, İsmail; Eroğlu, Mustafa

doi:10.1080/10641955.2018.1540702

Cited by 8 publications

(2 citation statements)

References 28 publications

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“…Study has proved that SESN1 (sestrin1) protein is upregulated and exerted antiin ammatory response biological functions in atherosclerosis [7]. SESNs are considered to exerted protective functions during cardiovascular diseases such as atherosclerosis, AMI (acute myocardial infarction), CHD (chronic heart disease), cardiac hypertrophy, hypertension and other age-related diseases [8][9][10]. Previous studies revealed SESN1 regulated the level of IL-1β, NLRP3, and activation of NF-Kb mainly through AMPK(AMP-activated protein kinase)-mTROC pathway in atherosclerosis [11][12].…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein

Sun

Jiang

et al. 2021

Experimental Gerontology

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Background Aerobic exercise plays an important role in prevention and treatment of atherosclerosis but its role in in ammatory response is not completely clear. In ammatory response is the main pathological process during occurrence and development stage of atherosclerosis. SESNs are considered as antiin ammation protein in atherosclerosis. ResultsIn current study, a high expression level of SESN1 is identi ed under the condition of aerobic exercise, further investigation shows levels of IL-1β/IL-6/TNF-α are signi cantly suppressed compared to those atherosclerosis mice with no aerobic training. Besides, we nd that the activation of NK-κB signaling is impeded. Combine with our previous study, SESN1 is considered as the downstream factor of aerobic exercise which tend to inhibit the activation of in ammatory signaling and result in suppress the expression level of in ammatory factors. Another exciting nding is that MMP9/13 are also suppressed but the potential mechanism is unclear.Conclusion Overall, present study sheds light on the signi cance of aerobic exercise for in ammation and stability of plaque through SESN1 may help developing new clinical treatments of atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein

Sun

Jiang

et al. 2021

Experimental Gerontology

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“…We recently found that Sestrin2 expression is upregulated in the liver in response to obesity‐induced ER stress in order to protect against ER stress‐related liver pathologies . Elevation in levels of maternal serum Sestrin2 has been found in severe preeclampsia group, suggesting the role of Sestrin2 in the pathophysiology of preeclampsia. However, the involvement of Sestrin2 in the placenta during obesity‐related pregnancy has not yet been clarified.…”

Section: Introductionmentioning

confidence: 99%

Sestrin2 alleviates palmitate‐induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells

Lee

Shin

Hong

et al. 2020

American J Rep Immunol

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Problem Maternal obesity induces elevated saturated fatty acid palmitate levels in the blood and causes pregnancy complications such as gestational diabetes, preeclampsia, fetal growth abnormalities, and stillbirth. Sestrin2, a highly conserved stress‐inducible protein, is involved in the cellular responses of various stress conditions and homeostatic regulation. However, the effects of Sestrin2 on trophoblast cells have not yet been investigated. Here, we investigated the role of Sestrin2 in palmitate‐induced lipotoxicity and its underlying mechanisms in human first‐trimester trophoblast cells (Sw.71). Method of study Mouse placental tissues were obtained from low‐fat diet‐fed mice (n = 14) and high‐fat diet‐fed mice (n = 14) at gestation day 17.5. Sw.71 cells were treated with palmitate or bovine serum albumin as vehicle controls. The role of Sestrin2 in palmitate‐induced lipotoxicity was examined by immunocytochemistry, immunoblot analysis, quantitative real‐time PCR, and invasion assay. Results Expression of placental Sestrin2 was elevated in high‐fat diet‐fed dams compared to that of low‐fat diet‐fed dams. Prolonged treatment of Sw.71 cells with palmitate‐induced endoplasmic reticulum (ER) stress‐dependent expressions of Sestrin2 protein and mRNA, and the treatment also triggered apoptosis. Knockdown of Sestrin2 increased palmitate‐mediated ER stress, inflammatory signaling, and apoptosis. Furthermore, Sestrin2 suppressed impaired trophoblast invasion caused by palmitate and attenuated palmitate‐induced ER stress and inflammation via AMPK/mTORC1 pathways. Conclusion Our study provides the relationship between Sestrin2, AMPK/mTORC1 pathway, and trophoblast function, suggesting that Sestrin2 may be a novel potential therapeutic target for the prevention of pregnancy complications.

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Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes

et al. 2023

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Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

Cited by 8 publications

References 28 publications

Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein

Aerobic exercise inhibits inflammatory response in atherosclerosis via Sestrin1 protein

Sestrin2 alleviates palmitate‐induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells

Sestrin-2 and hypoxia-ınducible factor-1 alpha levels in major depressive disorder and its subtypes

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