Maternal Serum Zinc, Copper, Magnesium, and Iron in Spontaneous Abortions

Sairoz,; Prabhu, Krishnananda; Poojari, Vidyashree G.; Shetty, Sahana; Rao, Madhu; Kamath, Asha

doi:10.1007/s12291-022-01043-x

Cited by 8 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The included articles were observational studies published between 1979 and 2023 and involved 1,377 abortion cases (including 1,159 females with SA and 218 females with RPL), together with 3,289 normal pregnant females. Of the 28 articles included in this meta-analysis, six were completed in China ( 37 , 38 , 40 , 42 , 45 , 51 ), three in Egypt ( 26 , 30 , 31 ), three in Saudi Arabia ( 29 , 36 , 47 ), three in Iran ( 48 – 50 ), two in Mexico ( 33 , 39 ), two in Turkey ( 35 , 52 ), two in Poland ( 19 , 41 ), one in Nigeria ( 27 ), one in Croatia ( 28 ), one in Italy ( 32 ), one in Australia ( 34 ), one in Serbia ( 43 ), one in India ( 44 ), and one in Russia ( 46 ). The sample size of the included studies ranged from 38 to 1,447.…”

Section: Resultsmentioning

confidence: 99%

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Ren,

Wang,

Wen

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the association between blood heavy metal (zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd)) concentrations and spontaneous abortion (SA) and recurrent pregnancy loss (RPL) and explore the possible endocrine dysfunction associated with it.MethodsA literature search was performed in the PubMed, Embase, Cochrane Library, and Web of Science databases up to April 2023. The overall effects were expressed as the standard mean difference (SMD). Subgroup analysis was performed according to the type of abortion (SA or RPL). Stata 16.0 was utilized for data analysis.ResultsBased on the integrated findings, abortion women showed significantly lower Zn (SMD = −1.05, 95% CI: −1.74 to −0.36, p = 0.003) and Cu concentrations (SMD = −1.42, 95% CI: −1.97 to −0.87, p <0.001) and higher Pb (SMD = 1.47, 95% CI: 0.89–2.05, p <0.001) and Cd concentrations (SMD = 1.15, 95% CI: 0.45–1.85, p = 0.001) than normal pregnant women. Subgroup analysis showed that Zn and Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with RPL, whereas Cu deficiency and Cd and Pb exposure were significantly (p <0.05) associated with SA.ConclusionZn and Cu deficiencies and Pb and Cd exposure were associated with abortion. Endocrine dysfunction, such as insulin resistance, vitamin D insufficiency, and abnormal thyroid and sex hormone concentrations, is thought to be involved in heavy metal-related abortion.

show abstract

Section: Resultsmentioning

confidence: 99%

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Ren,

Wang,

Wen

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Nutrition imbalance during pregnancy profoundly affects both maternal and fetal health. For instance, iron deficiency is implicated with anemic-associated maternal deaths [ 124 ] and spontaneous abortion [ 125 ]. Vitamin D (VD) deficiency is associated with GDM, miscarriage, and stillbirth [ 126 ].…”

Section: Influence Of Environmental Factors On Fabp4 During Pregnancymentioning

confidence: 99%

Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health

Shi

Wang

et al. 2023

IJMS

View full text Add to dashboard Cite

Fatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It has been increasingly recognized that FABP4 dysfunction is associated with various metabolic syndromes, including obesity, diabetes, cardiovascular diseases, and metabolic inflammation. However, its explicit roles within the context of women’s reproduction and pregnancy remain to be investigated. In this review, we collate recent studies probing the influence of FABP4 on female reproduction, pregnancy, and even fetal health. Elevated circulating FABP4 levels have been found to correlate with impaired reproductive function in women, such as polycystic ovary syndrome and endometriosis. Throughout pregnancy, FABP4 affects maternal–fetal interface homeostasis by affecting both glycolipid metabolism and immune tolerance, leading to adverse pregnancy outcomes, including miscarriage, gestational obesity, gestational diabetes, and preeclampsia. Moreover, maternal FABP4 levels exhibit a substantial linkage with the metabolic health of offspring. Herein, we discuss the emerging significance and potential application of FABP4 in reproduction and pregnancy health and delve into its underlying mechanism at molecular levels.

show abstract

“…Several studies have indicated that insufficiencies in trace metals, including copper (Cu), Zinc (Zn), and magnesium (Mg), may increase the likelihood of unfavorable pregnancy outcomes. However, the administration of various micronutrient supplements without proper justification for their inadequacy and potential harm to the fetus has been observed [ 37 ]. The results of previous studies were conflicting, but this study shows a definite and noticeable result.…”

Section: Introductionmentioning

confidence: 99%

Comparison of zinc levels in mothers with and without abortion: A systematic review and meta-analysiss

Tousizadeh,

Mohammadi-Moghadam,

Mohammadian-Hafshejani

et al. 2024

Heliyon

View full text Add to dashboard Cite

Maternal Serum Zinc, Copper, Magnesium, and Iron in Spontaneous Abortions

Cited by 8 publications

References 19 publications

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Association between female circulating heavy metal concentration and abortion: a systematic review and meta-analysis

Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health

Comparison of zinc levels in mothers with and without abortion: A systematic review and meta-analysiss

Contact Info

Product

Resources

About