Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study

The short-term benefits for babies of less respiratory distress and fewer serious health problems in the first few weeks after birth support the use of repeat dose(s) of prenatal corticosteroids for women still at risk of preterm birth seven days or more after an initial course. These benefits were associated with a small reduction in size at birth. The current available evidence reassuringly shows no significant harm in early childhood, although no benefit.Further research is needed on the long-term benefits and risks for the woman and baby. Individual patient data meta-analysis may clarify how to maximise benefit and minimise harm.

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Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Crowther

¹

,

McKinlay

²

,

Middleton

³

et al. 2015

Cochrane Database of Systematic Reviews

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The short-term benefits for babies of less respiratory distress and fewer serious health problems in the first few weeks after birth support the use of repeat dose(s) of prenatal corticosteroids for women still at risk of preterm birth seven days or more after an initial course. These benefits were associated with a small reduction in size at birth. The current available evidence reassuringly shows no significant harm in early childhood, although no benefit.Further research is needed on the long-term benefits and risks for the woman and baby. Individual patient data meta-analysis may clarify how to maximise benefit and minimise harm.

show abstract

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Walters

¹

,

McKinlay

²

,

Middleton

³

et al. 2022

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study

Cited by 7 publications

References 6 publications

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes

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