Maternal Smoking During Pregnancy and the Risk of Childhood Cancer

McKinney, Patricia A.; Stiller, C.A.; Dahlquist, Gisela; Wall, Stig; Buckley, Jenifer; Hobbie, Wendy L.; Ruccione, Kathy; Sather, Harland N.; Woods, William G.; Hammond, G. Denman; Li, FrederickP.; Cunningham, AllanS.

doi:10.1016/s0140-6736(86)90393-4

Cited by 42 publications

(35 citation statements)

References 11 publications

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“…(1979) reported a 5-fold increase in the risk of brain tumours in children associated with maternal smoking during pregnancy; again, this study had a small sample size. This finding has not been confirmed by other studies, which appear to have a measure of consistency in reporting, as in this study, elevated OR that are not statistically significant (Neutel and Buck, 1971;John et al, 1991;Preston-Martin et al, 1982;Strjenfeldt et al, 1986;McKinney and Stiller, 1986;Howe et al, 1989;Cold et al, 1993).…”

Section: Discussioncontrasting

confidence: 92%

Mothers' active and passive smoking during pregnancy and risk of brain tumours in children

Filippini

Farinotti

Lovicu

et al. 1994

Intl Journal of Cancer

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As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and residence, were interviewed about their lifetime smoking habits. Mother's smoking during pregnancy was associated with an odds ratio (OR) of 1.7 (95% CI 0.8, 3.8) of brain tumour in her child although this was not statistically significant. Among non-smoking mothers, the risk for light and heavy exposure to passive smoking was 1.7 (0.8, 3.6) and 2.2 (1.1, 4.5) respectively, and a statistically significant dose-response relationship was found (p trend = 0.02). These results must be interpreted within the constraints of the relatively small sample size and the likely misclassification produced by the difference between the potential for exposure to passive smoke and the true exposure. However, they add another piece of information to the growing body of evidence available about the health consequences both of active and of passive smoking and highlight the need for more information about this putative association.

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Section: Discussioncontrasting

confidence: 92%

Mothers' active and passive smoking during pregnancy and risk of brain tumours in children

Filippini

Farinotti

Lovicu

et al. 1994

Intl Journal of Cancer

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“…The IRESCC was established to investigate the role of possible aetiological factors in childhood cancer with particular emphasis on environmental exposures to the foetus and family history of diseases (Cartwright et al, 1984;Hopton et al, 1985;Johnston et al, 1986;McKinney and Stiller, 1986;McKinney et al, 1985;1987;Hartley et al, 1988a;1988b;Birch et al, 1990;Mann et al, 1993). Study design, control selection and data collection procedures have been published in some considerable detail ; a summary is provided here.…”

Section: Methodsmentioning

confidence: 99%

Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC)

et al. 2001

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Summary Parental smoking data have been re-abstracted from the interview records of the Inter-Regional Epidemiological Study of Childhood Cancer (IRESCC) to test further the hypothesis that paternal cigarette smoking is a risk factor for the generality of childhood cancer. Reported cigarette smoking habits for the parents of 555 children diagnosed with cancer in the period 1980-1983 were compared, in two separate matched pairs analyses, with similar information for the parents of 555 children selected from GP lists (GP controls) and for the parents of 555 hospitalized children (hospital controls). When cases were compared with GP controls there was a statistically significant positive trend (P = 0.02) between the risk of childhood cancer and paternal daily consumption of cigarettes before the pregnancy; there was no significant trend for maternal smoking habit. When cases were compared with hospital controls there was a statistically significant negative trend (P < 0.001) between the risk of childhood cancer and maternal daily consumption of cigarettes before the pregnancy; there was no significant trend for paternal smoking habit. Neither of the significant trends could be explained by adjustment for socioeconomic grouping, ethnic origin or parental age at the birth of the child, or by simultaneous analysis of parental smoking habits. Relations between maternal consumption of cigarettes and birth weights suggested that (maternal) smoking data were equally reliable for case and control subjects, although comparisons with national data suggested that the hospital control parents were unusually heavy smokers. These findings give some support for the hypothesis that paternal cigarette smoking is a potential risk factor for the generality of childhood cancers.

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“…Although risk of CBTs has been reported to increase with maternal exposure to passive smoking during pregnancy (1,2), many studies have found no effect of parental smoking on the development of CBTs (3)(4)(5)(6)(7)(8)(9)(10)(11). The potential relationship between parents' alcohol consumption and CBTs has been less well studied: a positive association between beer drinking and CBTs has been noted (10,12), while other studies have been negative (1,13).…”

Section: Original Articlementioning

confidence: 99%

Parental Cigarette Smoking, Hard Liquor Consumption and the Risk of Childhood Brain Tumors-A Case Study in Northeast China

2000

Acta Oncologica

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Maternal Smoking During Pregnancy and the Risk of Childhood Cancer

Cited by 42 publications

References 11 publications

Mothers' active and passive smoking during pregnancy and risk of brain tumours in children

Mothers' active and passive smoking during pregnancy and risk of brain tumours in children

Childhood cancer and parental use of tobacco: findings from the inter-regional epidemiological study of childhood cancer (IRESCC)

Parental Cigarette Smoking, Hard Liquor Consumption and the Risk of Childhood Brain Tumors-A Case Study in Northeast China

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