Maternal Spirulina supplementation during pregnancy and lactation partially prevents oxidative stress, glial activation and neuronal damage in protein malnourished F1 progeny

Sinha, Shrstha; Patro, Nisha; Tiwari, Pramod Kumar

doi:10.1016/j.neuint.2020.104877

Cited by 17 publications

(11 citation statements)

References 102 publications

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“…In addition, it was reported that Spirulina caused a reduction of CR3 and MHC II expression on microglia cells that lose the typical shape of activated phagocytic cells. Finally, Spirulina treatment attenuated MDA levels, modulated superoxide dismutase (SOD) and catalase (CAT) activities, increased cerebral cortical thickness, improved neuronal morphology, and increased dendritic arbor complexity, thus enhancing behavioral and cognitive functions [ 64 ].…”

Section: Role Of Spirulina In the Brainmentioning

confidence: 99%

Beneficial Effects of Spirulina Consumption on Brain Health

et al. 2022

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Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels of functional compounds, such as phycocyanins, phenols and polysaccharides, with anti-inflammatory, antioxidant, immunomodulating properties both in vivo and in vitro. Several scientific publications have suggested its positive effects in various pathologies such as cardiovascular diseases, hypercholesterolemia, hyperglycemia, obesity, hypertension, tumors and inflammatory diseases. Lately, different studies have demonstrated the neuroprotective role of Spirulina on the development of the neural system, senility and a number of pathological conditions, including neurological and neurodegenerative diseases. This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson’s disease, Alzheimer’s disease and Multiple Sclerosis; due to these properties, Spirulina could be considered a potential natural drug.

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Section: Role Of Spirulina In the Brainmentioning

confidence: 99%

Beneficial Effects of Spirulina Consumption on Brain Health

et al. 2022

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“…Pretreatment with spirulina significantly reduced the experimental neurological deficits and restored the decreased superoxide dismutase (SOD, glutathione (GSH) and catalase (CAT), indicating a clear association with antioxidant enzymatic activity [ 59 ]. Other experimental models of neuronal protection have provided further evidence of spirulina antioxidant and anti-inflammatory activity in the brain [ 60 , 61 , 62 , 63 , 64 , 65 ].…”

Section: Spirulina and Brain Health: In Vivo Evidence And Related Mechanism Of Actionmentioning

confidence: 99%

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

Sorrenti

Castagna²,

Fortinguerra

et al. 2021

Marine Drugs

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Spirulina microalgae contain a plethora of nutrient and non-nutrient molecules providing brain health benefits. Numerous in vivo evidence has provided support for the brain health potential of spirulina, highlighting antioxidant, anti-inflammatory, and neuroprotective mechanisms. Preliminary clinical studies have also suggested that spirulina can help to reduce mental fatigue, protect the vascular wall of brain vessels from endothelial damage and regulate internal pressure, thus contributing to the prevention and/or mitigating of cerebrovascular conditions. Furthermore, the use of spirulina in malnourished children appears to ameliorate motor, language, and cognitive skills, suggesting a reinforcing role in developmental mechanisms. Evidence of the central effect of spirulina on appetite regulation has also been shown. This review aims to understand the applicative potential of spirulina microalgae in the prevention and mitigation of brain disorders, highlighting the nutritional value of this “superfood”, and providing the current knowledge on relevant molecular mechanisms in the brain associated with its dietary introduction.

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“…This is an encouraging result for the treatment of this neurodegenerative pathology. The data described are also encouraging for possible future clinical applications of Spirulina in the field of nerve regeneration and/or reconstructive nerve surgery [ 119 , 120 , 121 ].…”

Section: Applications In Central and Peripheral Nervous Systemmentioning

confidence: 95%

Wide Range Applications of Spirulina: From Earth to Space Missions

et al. 2022

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Spirulina is the most studied cyanobacterium species for both pharmacological applications and the food industry. The aim of the present review is to summarize the potential benefits of the use of Spirulina for improving healthcare both in space and on Earth. Regarding the first field of application, Spirulina could represent a new technology for the sustainment of long-duration manned missions to planets beyond the Lower Earth Orbit (e.g., Mars); furthermore, it could help astronauts stay healthy while exposed to a variety of stress factors that can have negative consequences even after years. As far as the second field of application, Spirulina could have an active role in various aspects of medicine, such as metabolism, oncology, ophthalmology, central and peripheral nervous systems, and nephrology. The recent findings of the capacity of Spirulina to improve stem cells mobility and to increase immune response have opened new intriguing scenarios in oncological and infectious diseases, respectively.

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Maternal Spirulina supplementation during pregnancy and lactation partially prevents oxidative stress, glial activation and neuronal damage in protein malnourished F1 progeny

Cited by 17 publications

References 102 publications

Beneficial Effects of Spirulina Consumption on Brain Health

Beneficial Effects of Spirulina Consumption on Brain Health

Spirulina Microalgae and Brain Health: A Scoping Review of Experimental and Clinical Evidence

Wide Range Applications of Spirulina: From Earth to Space Missions

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