Maternal starvation and progesterone secretion, litter size, and growth in the pig.

Hard, D.L.; Anderson, L. L.

doi:10.1152/ajpendo.1979.237.3.e273

Cited by 19 publications

(24 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structural and functional properties of ovine corpora lutea of pregnancy were not altered by plane of nutrition. Moreover, maternal nutrient restriction during the middle third of gestation in pigs had no effect on ovarian progesterone production or fetal survival [46]. Morphometric data for sheep corpora lutea are consistent with previous reports summarized by Sawyer [23].…”

Section: Discussionsupporting

confidence: 85%

Ovarian responses to undernutrition in pregnant ewes, USA

Murdoch

Kirk

Vonnahme

et al. 2003

Reprod Biol Endocrinol

View full text Add to dashboard Cite

In most mammals oogonia proliferate by mitosis and begin meiotic development during fetal life. Previous studies indicated that there is a delay in the progression to the first stage of meiotic arrest in germ cells of female fetuses of undernourished ewes. We report that underfeeding (50% NRC requirement beginning on Day 28 of pregnancy) provokes an increase in oxidative base lesions within DNA of mid-gestational (Day 78) fetal oogonia; this condition was associated with up-regulation of the tumor suppressor/cell-cycle arrest modulator p53, antiapoptotic factor Bcl-2, and base-excision repair polymerase β. Fetal ovarian weights and germ cell concentrations were not altered by nutrient deprivation. Ovaries of ewes on control diets (100% NRC) contained more tertiary follicles than their restricted counterparts; however, peripheral venous estradiol-17β was not different between groups. There was no effect of treatment on p53 accumulation in maternal oocytes. Luteal structure-function was not perturbed by undernutrition. No fetal losses were attributed to the dietary restriction. It is proposed that DNA of interphase fetal oogonia is vulnerable to oxidative insults perpetrated by a nutritional stress to the dam, and that multiple/integrated adaptive molecular response mechanisms of cell-cycle inhibition (providing the time required for base repairs) and survival hence sustain the genomic integrity and population stability of the germline.

show abstract

Section: Discussionsupporting

confidence: 85%

Ovarian responses to undernutrition in pregnant ewes, USA

Murdoch

Kirk

Vonnahme

et al. 2003

Reprod Biol Endocrinol

View full text Add to dashboard Cite

show abstract

“…Reduced neonatal survivability, growth and development associated with low birth weights have led to considerable interest in factors affecting fetal growth. Some factors shown in previous investigations to affect fetal growth are uterine space (Perry and Rowell, 1969), uterine environment (Walton and Hammond, 1938;GregOry et al, 1978)) genetic potential (Walton and Hammond, 1938), nutrition (Wallace, 1948;Prior and Christenson, 1976;Hard and AnderSon, 1979;Korimlk et al, 1981) and blood flow to the fetus (Wigglesworth, 1964;Wootton et al,, 1977).…”

mentioning

confidence: 98%

The Relationship of Fetal Weight to Serum Albumin and Alpha-Fetoprotein in Swine

Stone¹,

Christenson²

1982

Journal of Animal Science

View full text Add to dashboard Cite

The within-litter relationship of fetal weight to fetal serum albumin and alpha-fetoprotein (AFP) was investigated at d 30 to 40, 45 to 50, 50 to 60, 75 to 85 and 90 to 105 of gestation in swine. Regression equations were calculated on individual litters and regression coefficients pooled across litters within each gestational age group. Coefficients for the regression of albumin on fetal weight (microgram . ml-1 . g fetus-1) were significant over all groups and ranged from 22.5 +/- 6.6 to d 45 to 50 to .7 +/- .2 at d 95 to 105. There was no significant relationship between AFP levels and fetal weight at any gestational age. Unilateral ovariectomy-hysterectomy was performed before mating to study effects of uterine crowding on the relationship of fetal weight to AFP and albumin. Although the total number of ovulations was not different from controls, this treatment resulted in only about 1.3 more fetuses/uterine horn compared with controls at either d 40 or 60 of gestation. Fetal weights in crowded litters were not different from controls. However, AFP levels in fetuses from crowded litters were lower than in control fetuses at d 40 (4.5 +/- .1 vs 6.7 +/- .5 mg/ml). Albumin levels in crowded fetuses were significantly lower than in controls at d 60 (342 +/- 50 vs 653 +/- 41 micrograms/ml). Because none of these differences in albumin or AFP could be attributed to variation in fetal weight or fetal number at the time of sample collection, it is possible that more extreme uterine crowding earlier in development resulted in these differences. These results demonstrate that fetal serum albumin concentrations are related to fetal weight when analyzed on a within-litter basis and that unilateral ovariectomy-hysterectomy may affect serum concentrations of both AFP and albumin early in fetal development. Future studies involving the regulation of synthesis of these proteins at the cellular level during development should provide information as to how factors affecting overall fetal growth and development influence the expression of a single gene. Previously, such markers that are amenable to study early in development have been lacking.

show abstract

“…Without the fasted control group, the effects of maternal diabetes would be confounded due to elevated levels of both glucose and free fatty acids. Other studies have shown that 40 d fasting during a period of rapid fetal growth in the pig had no affect on total litter weight at birth (Hard and Anderson, 1979). In the present study, sows were fasted for 20 d during a period of slower fetal growth.…”

Section: Introductionmentioning

confidence: 46%

The Effect of Maternal Diabetes and Fasting on Fetal Adipose Tissue Histochemistry in the Pig

Hausman

Kasser

Martin

1982

Journal of Animal Science

View full text Add to dashboard Cite

The effects of maternal diabetes (induced d 78 of gestation) and food deprivation (last 20 d of gestation) on the histochemical disposition of fetal adipose tissue at 112 d of gestation were determined. In both cases, there was an increased number of fat cell clusters by comparison with the control. In the fetuses of diabetic pigs, there were striking effects on adipocyte size and the extent of lipid filling of presumptive adipose space. In these fetuses, the adipocytes were large and many were unilocular, whereas, those in the fetuses of control and fasted pigs were smaller. The adipose tissue space of the control was "empty" compared with that of fetuses of diabetic pigs. Adipocytes from fetuses of diabetic pigs contained intracellular glycogen deposits, which were not present in adipocytes of control and fasted progeny. Maternal fasting and diabetes increased the number of lipid-containing adipocytes in fetal adipose tissue. An additional effect of maternal diabetes was to increase fetal adipocyte size over that of fetuses of control and fasted pigs.

show abstract

Maternal starvation and progesterone secretion, litter size, and growth in the pig.

Cited by 19 publications

References 10 publications

Ovarian responses to undernutrition in pregnant ewes, USA

Ovarian responses to undernutrition in pregnant ewes, USA

The Relationship of Fetal Weight to Serum Albumin and Alpha-Fetoprotein in Swine

The Effect of Maternal Diabetes and Fasting on Fetal Adipose Tissue Histochemistry in the Pig

Contact Info

Product

Resources

About