Maternal stress in the postpartum period is associated with altered human milk fatty acid composition

Juncker, Hannah G.; Naninck, E.F.G.; Schipper, Lidewij; Lucassen, Paul J.; Goudoever, Johannes B. van; Rooij, Susanne R. de; Kőrösi, Anikó

doi:10.1016/j.clnu.2022.09.013

Cited by 12 publications

(2 citation statements)

References 74 publications

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“…More recently, studies have shown that prior stress exposure influences maternal care across generations ( Rosenblatt, 1975 ; Purcell et al, 2011 ; Orso et al, 2019 ; Nephew et al, 2017 ; Zaidan et al, 2023 ). Maternal stress also influences lactation and breastmilk composition, ( Purcell et al, 2011 ; Ziomkiewicz et al, 2021 ; Juncker et al, 2023 ; Pfister and Muir, 2009 ) which significantly influences offspring development and stress-related phenotypes ( Abbink et al, 2020 ; Walker et al, 2004 ). Thus, the nongenomic transmission of MPS phenotypes involves both the maternal germline and behavior, the mechanisms of which are important to dissect.…”

Section: Limitations Of and Considerations For Preclinical Research O...mentioning

confidence: 99%

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

Rice,

Gil,

Baratta

et al. 2024

Neurobiology of Stress

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Section: Limitations Of and Considerations For Preclinical Research O...mentioning

confidence: 99%

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

Rice,

Gil,

Baratta

et al. 2024

Neurobiology of Stress

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“…Although rarely taken into account, maternal stress is an important factor, whose appearance and inadequate management could lead to a poor establishment of breastfeeding, or even alter the production or modify the composition of breast milk. We examined the association between postnatal maternal stress and the production and composition of breast milk through the process of bacterial colonization of the intestine of very premature infants [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Maternal Stress on Breast Milk Production and the Microbiota of Very Premature Infants

Fernández-Tuñas,

Pérez-Muñuzuri,

Trastoy-Pena

et al. 2023

Nutrients

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Perinatal stress experienced by mothers of very premature newborns may influence the mother’s milk and the infant’s intestinal microbiota. This prospective study of mothers of very preterm infants fed with mother’s own milk (MOM) was carried out in a tertiary hospital over a 2-year period. The assessment of maternal stress in 45 mothers of 52 very preterm newborns using the parental stress scale (PSS:NICU) revealed an inverse relationship between stress and MOM production in the first days of life (p = 0.012). The greatest contributor to stress was the one related to the establishment of a mother–child bond. Maternal stress was lower in mothers in whom the kangaroo method was established early (p = 0.011) and in those with a higher educational level (p = 0.032). Levels of fecal calprotectin (FC) decreased with the passage of days and were directly correlated with birthweight (p = 0.044). FC levels 7 days post-delivery were lower in newborns that received postnatal antibiotics (p = 0.027). High levels of maternal stress resulted in progressive decreases and increases in the proportions of Firmicutes and Proteobacteria species, respectively, over 15 days post-delivery, both in MOM and in fecal samples from premature newborns. These findings underscore the importance of recognizing and appropriately managing maternal stress in neonatal units, given its marked influence on both the microbiota of maternal milk and the intestinal microbiota of premature newborns.

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Maternal stress in the early postpartum period is associated with alterations in human milk microbiome composition

Juncker,

Jakobsen,

Naninck

et al. 2025

Brain, Behavior, and Immunity

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Maternal stress in the postpartum period is associated with altered human milk fatty acid composition

Cited by 12 publications

References 74 publications

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

Effects of Maternal Stress on Breast Milk Production and the Microbiota of Very Premature Infants

Maternal stress in the early postpartum period is associated with alterations in human milk microbiome composition

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