Maternal stress induces adult reduced REM sleep and melatonin level

Feng, Ping; Hu, Yuan; Vurbic, Drina; Guo, Yang

doi:10.1002/dneu.20961

Cited by 13 publications

(17 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we have shown that adult rats that were subjected to MS exhibited increased W and reduced sleep in the spontaneous sleep-wake cycle, as has been documented previously [4,6] (Fig. 1).…”

Section: Discussionsupporting

confidence: 87%

“…As we have previously discussed, stressful events in early life, such as MS, result in enhanced W and reduced sleep during adulthood [4]; in addition, this stress-related animal model has been shown to induce long-lasting neurochemical changes, and the lateral hypothalamus, a brain structure that is involved in the maintenance of W [8], seems to be sensitive to this phenomenon. In this regard, it has been reported that MS induces an increase in hypothalamic OX [16].…”

Section: Discussionmentioning

confidence: 82%

See 1 more Smart Citation

2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation

et al. 2014

View full text Add to dashboard Cite

We have previously reported that maternal separation (MS) for 3 h daily during the first two postnatal weeks increases wakefulness, whereas it reduces sleep in rats. Oleamide, an agonist of the cannabinoid receptor type 1, increases sleep in MS rats to such a level that we cannot differentiate their sleep patterns from those of their non-MS (NMS) siblings. However, 2-arachidonoylglycerol (2-AG), an endocannabinoid, infused into the lateral hypothalamus of NMS rats at the beginning of the dark phase of the cycle increases rapid eye movement sleep and the expression of c-Fos on the rapid eye movement sleep promoting melanin-concentrating hormone neurons. We recorded the sleep-wake cycle of adult rats subjected to MS for 3 h daily from postnatal days 2 to 16, as well as in their NMS siblings. Besides the electrodes for recording the sleep-wake cycle, a couple of cannulae aimed bilaterally to the lateral hypothalamus were implanted to infuse 2-AG. We found that administration of 2-AG into the lateral hypothalamus of MS rats at the beginning of the light phase of the cycle restores sleep, whereas sleep and wakefulness of NMS rats under 2-AG infusion do not show any significant change.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 82%

2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…morningness versus eveningness) and sleep disorders, as well as medication, might have an impact on the growth of fetal PGV, resulting in smaller pineal glands in the newborn which, again, might cause sleep disturbances in the years to come. One study in primates (Seron‐Ferre et al ., ) and one in rodents (Feng et al ., ) provided evidence that certain conditions during pregnancy might influence the development of the newborn circadian system and its components. Similar findings have been demonstrated in other animal studies (reviewed in Seron‐Ferre et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study

Bumb

Schilling

Enning

et al. 2014

Journal of Sleep Research

View full text Add to dashboard Cite

SUMMARYLittle is known about the relation between pineal volume and insomnia. Melatonin promotes sleep processes and, administered as a drug, it is suitable to improve primary and secondary sleep disorders in humans. Recent magnetic resonance imaging studies suggest that human plasma and saliva melatonin levels are partially determined by the pineal gland volume. This study compares the pineal volume in a group of patients with primary insomnia to a group of healthy people without sleep disturbance. Pineal gland volume (PGV) was measured on the basis of high-resolution 3 Tesla MRI (T1-magnetization prepared rapid gradient echo) in 23 patients and 27 controls, matched for age, gender and educational status. Volume measurements were performed conventionally by manual delineation of the pineal borders in multi-planar reconstructed images. Pineal gland volume was significantly smaller (P < 0.001) in patients (48.9 AE 26.6 mm 3 ) than in controls (79 AE 30.2 mm 3 ). In patients PGV correlated negatively with age (r = À0.532; P = 0.026). Adjusting for the effect of age, PGV and rapid eye movement (REM) latency showed a significant positive correlation (r S = 0.711, P < 0.001) in patients. Pineal volume appears to be reduced in patients with primary insomnia compared to healthy controls. Further studies are needed to clarify whether low pineal volume is the basis or the consequence of functional sleep changes to elucidate the molecular pathology for the pineal volume loss in primary insomnia.

show abstract

“…[1,2] Recent evidence indicates that sleep disturbance is one of the long-term effects of early-life stress [3] based on consistent association between childhood adversities and poor sleep quality in adult humans [4–6] and rodents. [7,8] Given that sleep disturbance causes a severe burden on individuals and society and constitutes an early predictor of the future development of emotional and cognitive disorders, [9,10] understanding how early-life stress influences sleep behaviors has significant clinical importance.…”

Section: Introductionmentioning

confidence: 99%

Early-life stress alters sleep structure and the excitatory-inhibitory balance in the nucleus accumbens in aged mice

Wang

et al. 2019

Chinese Medical Journal

View full text Add to dashboard Cite

Background: Exposure to adverse experiences in early life may profoundly reshape the neurodevelopmental trajectories of the brain and lead to long-lasting behavioral and neural alterations. One deleterious effect of early-life stress that manifests in later life is sleep disturbance, but this has not been examined in aged mice and the underlying neural mechanisms remain unknown. Considering the important role of the nucleus accumbens (NAc) in the sleep-wake regulation, this study aimed to assess the effects of early-life stress on the sleep behaviors in aged mice and the potential involvement of the NAc in stress-induced sleep abnormalities. Methods: Twenty aged male C57BL/6 mice (>16 months, n = 10 per group) were used in this study. During post-natal days 2 to 9, dams were provided with either sufficient (control) or a limited nesting and bedding materials (stressed). When the mice were 16 to 17 months old, their sleep-wake behaviors were recorded over 24 h using electroencephalogram and electromyelogram. The amount of each sleep-wake stage, mean duration, and stage transition was analyzed. Then, five animals were randomly chosen from each group and were used to measure the expression levels of vesicular glutamate transporter-1 (VGluT1) and vesicular transporters of γ-aminobutyric acid (VGAT) in the NAc using immunohistochemistry. Group comparisons were carried out using Student t test or analysis of variances when appropriate. Results: Compared with the control mice, the early-life stressed aged mice spent less time awake over 24 h (697.97 ± 77.47 min vs. 631.33 ± 34.73 min, t 17 = 2.376, P = 0.030), accordingly, non-rapid eye movement sleep time was increased (667.37 ± 62.07 min vs. 723.54 ± 39.21 min, t 17 = 2.326, P = 0.033) and mean duration of rapid eye movement sleep was prolonged (73.00 ± 8.98 min vs. 89.39 ± 12.69 min, t 17 = 3.277, P = 0.004). Meanwhile, we observed decreased VGluT1/VGAT ratios in the NAc in the stressed group ( F (1, 16) = 81.04, P < 0.001). Conclusion: Early adverse experiences disrupt sleep behaviors in aged mice, which might be associated with the excitatory-inhibitory imbalance in the NAc.

show abstract

Maternal stress induces adult reduced REM sleep and melatonin level

Cited by 13 publications

References 60 publications

2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation

2-Arachidonoylglycerol into the lateral hypothalamus improves reduced sleep in adult rats subjected to maternal separation

Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study

Early-life stress alters sleep structure and the excitatory-inhibitory balance in the nucleus accumbens in aged mice

Contact Info

Product

Resources

About