Maternal Thyroid Function in the First Twenty Weeks of Pregnancy and Subsequent Fetal and Infant Development: A Prospective Population-Based Cohort Study in China

Su, Puyu; Huang, Kun; Hao, Jiahu; Xu, Yong; Yan, Shuangqin; Li, Tao; Xu, Yuanhong; Tao, Fangbiao

doi:10.1210/jc.2011-0274

Cited by 246 publications

(199 citation statements)

References 28 publications

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“…Multiple studies have reported an association of SCH with an increase in the risk of adverse pregnancy and neonatal outcomes, including pregnancy loss, preterm delivery, gestational diabetes, gestational hypertension, preeclampsia, placental abruption, premature rupture of membranes, intrauterine growth restriction, low birth weight, small for gestational age, low Apgar score, and neonatal death (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Furthermore, high TSH levels in women during pregnancy have been associated with an increased risk of neurocognitive deficits in the offspring (17).…”

mentioning

confidence: 99%

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Maraka

Ospina

O’Keeffe

et al. 2016

Thyroid

314

210

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Background: The impact of subclinical hypothyroidism (SCH) and of levothyroxine replacement in pregnant women with SCH is unclear. The aims of this study were to assess (i) the impact of SCH during pregnancy on maternal and neonatal outcomes, and (ii) the effect of levothyroxine replacement therapy in these patients. Methods: Ovid MEDLINE In-Process & Other Non-Indexed Citations, Ovid MEDLINE, the Cochrane Controlled Trials Register, Ovid EMBASE, Web of Science, and Scopus were searched from inception to January 2015. Randomized trials and cohort studies of pregnant women with SCH that examined adverse pregnancy and neonatal outcomes were included. Reviewers extracted data and assessed methodological quality in duplicate. Eighteen cohort studies at low-to-moderate risk of bias were included. Compared with euthyroid pregnant women, pregnant women with SCH were at higher risk for pregnancy loss (relative risk [RR] . One study at high risk of bias compared pregnant women with SCH who received levothyroxine to those who did not and found no significant decrease in the rate of pregnancy loss, preterm delivery, gestational hypertension, low birth weight, or low Apgar score. Conclusions: SCH during pregnancy is associated with multiple adverse maternal and neonatal outcomes. The value of levothyroxine therapy in preventing these adverse outcomes remains uncertain.

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mentioning

confidence: 99%

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Maraka

Ospina

O’Keeffe

et al. 2016

Thyroid

314

210

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show abstract

“…[1][2][3][4][5] In 1999, interest in undiagnosed maternal thyroid dysfunction was heightened by studies suggesting an association between subclinical thyroid hypofunction and impaired fetal neuropsychological development. 6,7 In one report, children of women whose serum thyrotropin levels during pregnancy were greater than the 98th percentile had a lower IQ than children of matched controls who had a normal thyrotropin level.…”

mentioning

confidence: 99%

Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy

Casey

Thom

Peaceman³

et al. 2017

Obstetrical &Amp; Gynecological Survey

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“…Five studies on LBW infants and hyperthyroidism pregnancies were retrieved [10] [13] [18] [19] [20]. A meta-analysis showed an increased risk of LBW infants by 1.3-fold with maternal hyperthyroidism compared with normal pregnancies (OR 1.30; 95% CI 1.11 -1.54; p = 0.002; Figure 2).…”

Section: Low Birth Weight Infants and Hyperthyroidismmentioning

confidence: 99%

“…Over the last 20 years, several studies have investigated the effects of maternal thyroid dysfunction during pregnancy on neonatal birth weight. However, these results remain controversial, as some of the published data on maternal thyroid dysfunction have shown an associated increased risk of LBW [6] [7] [10], whereas other studies have found no association with neonatal birth weight [8] [11] [12] [13] [14].…”

Section: Introductionmentioning

confidence: 99%

Maternal Thyroid Disease and Neonatal Low Birth Weight: A Systematic Review and Meta-Analysis

Chiu¹,

Zhang²,

Zhao³

et al. 2017

OJOG

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Objective: Thyroid disorder is a common endocrine complication in pregnant women: the association between neonatal low birth weight (LBW) and thyroid dysfunction during pregnancy has not been definitely confirmed. We conduct a systematic literature review and meta-analysis of the adverse fetal complication of LBW in maternal thyroid disease, including overt and subclinical hyperthyroidism and hypothyroidism. Methods: Relevant studies in English published between 1990 and 2016 were identified by searching PubMed, Medicine, and Embase databases. Cohort studies that evaluated the association between LBW infants and overt and subclinical hyperthyroidism or hypothyroidism during pregnancy and included a healthy pregnancy reference group were selected. The combined odds ratio (OR) with 95% confidence intervals (CI) were calculated to evaluate this relationship. Results: A total of 11 cohort studies (1,171,052 participants) assessed the association between maternal thyroid disease and LBW infants. An increased risk for LBW in hyperthyroidism pregnancies was demonstrated (OR: 1.30, 95% CI 1.11 -1.54; p = 0.02). No significant increased risk for LBW was detected in subclinical hyperthyroidism (OR 1.03; 95% CI 0.72 -1.48; p = 0.87), or hypothyroidism pregnancies (overt: OR 0.98; 95% CI 0.88 -1.10; p = 0.75; subclinical: OR 1.29; 95% CI 0.81 -2.04; p = 0.28). Conclusion: Data show a higher trend towards an increased risk of LBW among infants from maternal hyperthyroidism pregnancies. No association was seen in subclinical cases of hyperthyroidism or hypothyroidism during pregnancy.

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Maternal Thyroid Function in the First Twenty Weeks of Pregnancy and Subsequent Fetal and Infant Development: A Prospective Population-Based Cohort Study in China

Abstract: Thyroid dysfunction in the first 20 wk of pregnancy may result in fetal loss and dysplasia and some congenital malformations.

Cited by 246 publications

References 28 publications

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Subclinical Hypothyroidism in Pregnancy: A Systematic Review and Meta-Analysis

Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy

Maternal Thyroid Disease and Neonatal Low Birth Weight: A Systematic Review and Meta-Analysis

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